Retrospective analysis of the effect of angiotensin II receptor blocker versus [beta]-blocker on aortic root growth in paediatric patients with Marfan syndrome
Objectives Cardiovascular pathology, including aortic root dilation at the level of sinus of Valsalva (SV), is one of the major causes of morbidity in paediatric patients with Marfan syndrome (MFS). β-Blocker (BB) is well established to slow aortic dilation in MFS. Less is known about the effectiven...
Gespeichert in:
| Veröffentlicht in: | Heart (British Cardiac Society) 2014-02, Vol.100 (3), p.214 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 3 |
| container_start_page | 214 |
| container_title | Heart (British Cardiac Society) |
| container_volume | 100 |
| creator | Mueller, Goetz C Stierle, Lydia Stark, Veronika Steiner, Kristoffer von Kodolitsch, Yskert Weil, Jochen Mir, Thomas S |
| description | Objectives Cardiovascular pathology, including aortic root dilation at the level of sinus of Valsalva (SV), is one of the major causes of morbidity in paediatric patients with Marfan syndrome (MFS). β-Blocker (BB) is well established to slow aortic dilation in MFS. Less is known about the effectiveness of angiotensin II receptor blocker (ARB) on aortic dilation in paediatric patients with MFS. Methods 215 patients with MFS (9.01±5.7 years) were subject to a standardised diagnostic programme. Aortic root dilation was evaluated and followed up by echocardiography. In 48 cases, BB and ARB effects on aortic root dilation were evaluated. Effect of treatment was measured by comparison of z scores of SV before and after treatment initiation. Results Treatment by ARB and BB leads to significant reduction of SV dilation (p |
| doi_str_mv | 10.1136/heartjnl-2013-304946 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_1780732209</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4021119151</sourcerecordid><originalsourceid>FETCH-proquest_journals_17807322093</originalsourceid><addsrcrecordid>eNqNjs1KA0EQhAdRMP68gYcGz6szmWQ3OYtiDl7EgyASJpve7MR1eu3uJORpfFUnoHdP1VVf0ZQxV87eOOfL2xYD6zp1xdA6X3g7mo7KIzNwo3JyiF6P8-3H46K0vjo1ZyJra3NpUg7M9zMqk_RYa9wihBS6vUQBakBbBGyaTA4upFUkxSQxwWwGjDX2SgyLjuoPZNgiy0bgbYEa3ou_lBIEYo01MJHCimmnLeQXfcBlDMqZ9EEjJhXYxcyeAjchgezTkukTL8xJEzrBy189N9cP9y93j0XP9LVB0fmaNpxXy9xVE1v54dBO_f9aP4leZhI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1780732209</pqid></control><display><type>article</type><title>Retrospective analysis of the effect of angiotensin II receptor blocker versus [beta]-blocker on aortic root growth in paediatric patients with Marfan syndrome</title><source>BMJ Journals - NESLi2</source><source>PubMed Central</source><creator>Mueller, Goetz C ; Stierle, Lydia ; Stark, Veronika ; Steiner, Kristoffer ; von Kodolitsch, Yskert ; Weil, Jochen ; Mir, Thomas S</creator><creatorcontrib>Mueller, Goetz C ; Stierle, Lydia ; Stark, Veronika ; Steiner, Kristoffer ; von Kodolitsch, Yskert ; Weil, Jochen ; Mir, Thomas S</creatorcontrib><description>Objectives Cardiovascular pathology, including aortic root dilation at the level of sinus of Valsalva (SV), is one of the major causes of morbidity in paediatric patients with Marfan syndrome (MFS). β-Blocker (BB) is well established to slow aortic dilation in MFS. Less is known about the effectiveness of angiotensin II receptor blocker (ARB) on aortic dilation in paediatric patients with MFS. Methods 215 patients with MFS (9.01±5.7 years) were subject to a standardised diagnostic programme. Aortic root dilation was evaluated and followed up by echocardiography. In 48 cases, BB and ARB effects on aortic root dilation were evaluated. Effect of treatment was measured by comparison of z scores of SV before and after treatment initiation. Results Treatment by ARB and BB leads to significant reduction of SV dilation (p<0.05). The deviation of SV enlargement from normal as expressed by the rate of change in z scores was significantly reduced by a mean difference of -0.56±0.71 z scores (p<0.001) under ARB therapy and by a mean difference of -0.35±0.68 z scores (p<0.05) under BB therapy. The prophylactic effect of ARB and BB on aortic root dilation is similar in both groups (p>0.05). Conclusions Both concepts lead to a significant reduction of SV dilation. The effect of ARB and BB is similar. This is the first study concerning the comparison of ARB and BB in previously untreated paediatric patients with MFS. The results of the study show that both treatment strategies are beneficial in paediatric and adolescent patients.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/heartjnl-2013-304946</identifier><language>eng</language><publisher>London: BMJ Publishing Group LTD</publisher><subject>Child development ; Dissection ; Marfan syndrome ; Mortality ; Pathogenesis ; Surgery ; Teenagers</subject><ispartof>Heart (British Cardiac Society), 2014-02, Vol.100 (3), p.214</ispartof><rights>Copyright: 2014 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>Mueller, Goetz C</creatorcontrib><creatorcontrib>Stierle, Lydia</creatorcontrib><creatorcontrib>Stark, Veronika</creatorcontrib><creatorcontrib>Steiner, Kristoffer</creatorcontrib><creatorcontrib>von Kodolitsch, Yskert</creatorcontrib><creatorcontrib>Weil, Jochen</creatorcontrib><creatorcontrib>Mir, Thomas S</creatorcontrib><title>Retrospective analysis of the effect of angiotensin II receptor blocker versus [beta]-blocker on aortic root growth in paediatric patients with Marfan syndrome</title><title>Heart (British Cardiac Society)</title><description>Objectives Cardiovascular pathology, including aortic root dilation at the level of sinus of Valsalva (SV), is one of the major causes of morbidity in paediatric patients with Marfan syndrome (MFS). β-Blocker (BB) is well established to slow aortic dilation in MFS. Less is known about the effectiveness of angiotensin II receptor blocker (ARB) on aortic dilation in paediatric patients with MFS. Methods 215 patients with MFS (9.01±5.7 years) were subject to a standardised diagnostic programme. Aortic root dilation was evaluated and followed up by echocardiography. In 48 cases, BB and ARB effects on aortic root dilation were evaluated. Effect of treatment was measured by comparison of z scores of SV before and after treatment initiation. Results Treatment by ARB and BB leads to significant reduction of SV dilation (p<0.05). The deviation of SV enlargement from normal as expressed by the rate of change in z scores was significantly reduced by a mean difference of -0.56±0.71 z scores (p<0.001) under ARB therapy and by a mean difference of -0.35±0.68 z scores (p<0.05) under BB therapy. The prophylactic effect of ARB and BB on aortic root dilation is similar in both groups (p>0.05). Conclusions Both concepts lead to a significant reduction of SV dilation. The effect of ARB and BB is similar. This is the first study concerning the comparison of ARB and BB in previously untreated paediatric patients with MFS. The results of the study show that both treatment strategies are beneficial in paediatric and adolescent patients.</description><subject>Child development</subject><subject>Dissection</subject><subject>Marfan syndrome</subject><subject>Mortality</subject><subject>Pathogenesis</subject><subject>Surgery</subject><subject>Teenagers</subject><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNjs1KA0EQhAdRMP68gYcGz6szmWQ3OYtiDl7EgyASJpve7MR1eu3uJORpfFUnoHdP1VVf0ZQxV87eOOfL2xYD6zp1xdA6X3g7mo7KIzNwo3JyiF6P8-3H46K0vjo1ZyJra3NpUg7M9zMqk_RYa9wihBS6vUQBakBbBGyaTA4upFUkxSQxwWwGjDX2SgyLjuoPZNgiy0bgbYEa3ou_lBIEYo01MJHCimmnLeQXfcBlDMqZ9EEjJhXYxcyeAjchgezTkukTL8xJEzrBy189N9cP9y93j0XP9LVB0fmaNpxXy9xVE1v54dBO_f9aP4leZhI</recordid><startdate>20140201</startdate><enddate>20140201</enddate><creator>Mueller, Goetz C</creator><creator>Stierle, Lydia</creator><creator>Stark, Veronika</creator><creator>Steiner, Kristoffer</creator><creator>von Kodolitsch, Yskert</creator><creator>Weil, Jochen</creator><creator>Mir, Thomas S</creator><general>BMJ Publishing Group LTD</general><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>20140201</creationdate><title>Retrospective analysis of the effect of angiotensin II receptor blocker versus [beta]-blocker on aortic root growth in paediatric patients with Marfan syndrome</title><author>Mueller, Goetz C ; Stierle, Lydia ; Stark, Veronika ; Steiner, Kristoffer ; von Kodolitsch, Yskert ; Weil, Jochen ; Mir, Thomas S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_17807322093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Child development</topic><topic>Dissection</topic><topic>Marfan syndrome</topic><topic>Mortality</topic><topic>Pathogenesis</topic><topic>Surgery</topic><topic>Teenagers</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mueller, Goetz C</creatorcontrib><creatorcontrib>Stierle, Lydia</creatorcontrib><creatorcontrib>Stark, Veronika</creatorcontrib><creatorcontrib>Steiner, Kristoffer</creatorcontrib><creatorcontrib>von Kodolitsch, Yskert</creatorcontrib><creatorcontrib>Weil, Jochen</creatorcontrib><creatorcontrib>Mir, Thomas S</creatorcontrib><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mueller, Goetz C</au><au>Stierle, Lydia</au><au>Stark, Veronika</au><au>Steiner, Kristoffer</au><au>von Kodolitsch, Yskert</au><au>Weil, Jochen</au><au>Mir, Thomas S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retrospective analysis of the effect of angiotensin II receptor blocker versus [beta]-blocker on aortic root growth in paediatric patients with Marfan syndrome</atitle><jtitle>Heart (British Cardiac Society)</jtitle><date>2014-02-01</date><risdate>2014</risdate><volume>100</volume><issue>3</issue><spage>214</spage><pages>214-</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>Objectives Cardiovascular pathology, including aortic root dilation at the level of sinus of Valsalva (SV), is one of the major causes of morbidity in paediatric patients with Marfan syndrome (MFS). β-Blocker (BB) is well established to slow aortic dilation in MFS. Less is known about the effectiveness of angiotensin II receptor blocker (ARB) on aortic dilation in paediatric patients with MFS. Methods 215 patients with MFS (9.01±5.7 years) were subject to a standardised diagnostic programme. Aortic root dilation was evaluated and followed up by echocardiography. In 48 cases, BB and ARB effects on aortic root dilation were evaluated. Effect of treatment was measured by comparison of z scores of SV before and after treatment initiation. Results Treatment by ARB and BB leads to significant reduction of SV dilation (p<0.05). The deviation of SV enlargement from normal as expressed by the rate of change in z scores was significantly reduced by a mean difference of -0.56±0.71 z scores (p<0.001) under ARB therapy and by a mean difference of -0.35±0.68 z scores (p<0.05) under BB therapy. The prophylactic effect of ARB and BB on aortic root dilation is similar in both groups (p>0.05). Conclusions Both concepts lead to a significant reduction of SV dilation. The effect of ARB and BB is similar. This is the first study concerning the comparison of ARB and BB in previously untreated paediatric patients with MFS. The results of the study show that both treatment strategies are beneficial in paediatric and adolescent patients.</abstract><cop>London</cop><pub>BMJ Publishing Group LTD</pub><doi>10.1136/heartjnl-2013-304946</doi></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1355-6037 |
| ispartof | Heart (British Cardiac Society), 2014-02, Vol.100 (3), p.214 |
| issn | 1355-6037 1468-201X |
| language | eng |
| recordid | cdi_proquest_journals_1780732209 |
| source | BMJ Journals - NESLi2; PubMed Central |
| subjects | Child development Dissection Marfan syndrome Mortality Pathogenesis Surgery Teenagers |
| title | Retrospective analysis of the effect of angiotensin II receptor blocker versus [beta]-blocker on aortic root growth in paediatric patients with Marfan syndrome |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-20T04%3A43%3A36IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Retrospective%20analysis%20of%20the%20effect%20of%20angiotensin%20II%20receptor%20blocker%20versus%20%5Bbeta%5D-blocker%20on%20aortic%20root%20growth%20in%20paediatric%20patients%20with%20Marfan%20syndrome&rft.jtitle=Heart%20(British%20Cardiac%20Society)&rft.au=Mueller,%20Goetz%20C&rft.date=2014-02-01&rft.volume=100&rft.issue=3&rft.spage=214&rft.pages=214-&rft.issn=1355-6037&rft.eissn=1468-201X&rft_id=info:doi/10.1136/heartjnl-2013-304946&rft_dat=%3Cproquest%3E4021119151%3C/proquest%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1780732209&rft_id=info:pmid/&rfr_iscdi=true |