EFFECTS OF PITAVASTATIN ON MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND HIGH SENSITIVITY C REACTIVE PROTEIN IN ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION PATIENTS

EFFECTS OF PITAVASTATIN ON MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND HIGH SENSITIVITY C REACTIVE PROTEIN IN ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION PATIENTS

Objectives To observe pitavastatin mediated inflammatory factor monocyte chemotactic protein -1 (MCP-1) and high sensitivity C-reactive protein (hs-CRP) in patient with acute ST-segment elevation myocardial infarction. Methods 198 patients with consecutive elections ST-segment elevation acute myocar...

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Veröffentlicht in:Heart (British Cardiac Society) 2012-10, Vol.98 (Suppl 2), p.E196-E196
Hauptverfasser: Li, Faquan, Liao, Wei, Yan, Zhanglin
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container_title Heart (British Cardiac Society)
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creator Li, Faquan
Liao, Wei
Yan, Zhanglin
description Objectives To observe pitavastatin mediated inflammatory factor monocyte chemotactic protein -1 (MCP-1) and high sensitivity C-reactive protein (hs-CRP) in patient with acute ST-segment elevation myocardial infarction. Methods 198 patients with consecutive elections ST-segment elevation acute myocardial infarction were collected from January 2007 to December 2012, aged 32–88-years old, ruled out infectious diseases, cancer, collagen diseases, application of immunosuppressive drugs. All patients underwent emergency coronary intervention, were randomly divided into control group and early intervention pitavastatin group (undergoing emergency percutaneous coronary intervention 30 min to 1 h after oral administration of pitavastatin 4 mg), ELISA was used to measure the contents of MCP-1 and hs-CRP. Results (1) The levels of MCP-1 and hs-CRP in two groups increased 24 h after PCI (p
doi_str_mv 10.1136/heartjnl-2012-302920k.44
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Methods 198 patients with consecutive elections ST-segment elevation acute myocardial infarction were collected from January 2007 to December 2012, aged 32–88-years old, ruled out infectious diseases, cancer, collagen diseases, application of immunosuppressive drugs. All patients underwent emergency coronary intervention, were randomly divided into control group and early intervention pitavastatin group (undergoing emergency percutaneous coronary intervention 30 min to 1 h after oral administration of pitavastatin 4 mg), ELISA was used to measure the contents of MCP-1 and hs-CRP. Results (1) The levels of MCP-1 and hs-CRP in two groups increased 24 h after PCI (p&lt;0.01); (2) The levels of MCP-1 and hs-CRP in the intervention group was statistically significant compared with the control group 24 h later. Conclusions High-dose pitavastatin used in patients with Acute ST segment elevation myocardial infarction before percutaneous coronary intervention promotes MCP-1 and hs-CRP levels drop, reduce inflammatory response in patients.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/heartjnl-2012-302920k.44</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><ispartof>Heart (British Cardiac Society), 2012-10, Vol.98 (Suppl 2), p.E196-E196</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2012 Published by the BMJ Publishing Group Limited. 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Methods 198 patients with consecutive elections ST-segment elevation acute myocardial infarction were collected from January 2007 to December 2012, aged 32–88-years old, ruled out infectious diseases, cancer, collagen diseases, application of immunosuppressive drugs. All patients underwent emergency coronary intervention, were randomly divided into control group and early intervention pitavastatin group (undergoing emergency percutaneous coronary intervention 30 min to 1 h after oral administration of pitavastatin 4 mg), ELISA was used to measure the contents of MCP-1 and hs-CRP. Results (1) The levels of MCP-1 and hs-CRP in two groups increased 24 h after PCI (p&lt;0.01); (2) The levels of MCP-1 and hs-CRP in the intervention group was statistically significant compared with the control group 24 h later. Conclusions High-dose pitavastatin used in patients with Acute ST segment elevation myocardial infarction before percutaneous coronary intervention promotes MCP-1 and hs-CRP levels drop, reduce inflammatory response in patients.</description><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkV1r2zAYhc3YYF27_yDotVp9y7oUqpwIEjvYqrdcCduxadOPtHYK29_ZL53StL0uCCRePeccXk6SAIwuMKbi8qZvxv328R4ShAmkiCiC7i4Y-5KcYCbSw_j31_imnEOBqPye_JimLUKIqVScJP9sllnjK1BkYOW8rnXltXc5KHKwLPLCrL0FZm6Xhfa-1Mbr3INVWXjrcoiBzq_A3M3moLJ55byrnV8DA0obSVfbdxLEo811tKo8rOxsaaOLXdg6Rh2C1oXR5ZXTiwhmujSv01X8jFx1lnwbmvup__l2nybXmfVmDhfFzBm9gC1BikGpmg0WIi5KuWw2sukIo2zT8lapIUW9ooozoUgvU9GizUBb1KGOYyJlN3Rc0NPk_Oj7NO6eX_ppH7a7l_ExRgYsUyQJl0JFKj1S3bibprEfwtN4-9CMfwNG4dBIeG8kHBoJb40ExqIUHqW3077_86FrxrsgJJU85LUJpprxXyn3IYs8PfLtw_bzKf8B3SiUNg</recordid><startdate>201210</startdate><enddate>201210</enddate><creator>Li, Faquan</creator><creator>Liao, Wei</creator><creator>Yan, Zhanglin</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>201210</creationdate><title>EFFECTS OF PITAVASTATIN ON MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND HIGH SENSITIVITY C REACTIVE PROTEIN IN ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION PATIENTS</title><author>Li, Faquan ; Liao, Wei ; Yan, Zhanglin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b2094-79ad166135357ad7ac2434db5b99f80e93954692e786b0df3b0c0c51277cfc563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Faquan</creatorcontrib><creatorcontrib>Liao, Wei</creatorcontrib><creatorcontrib>Yan, Zhanglin</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Faquan</au><au>Liao, Wei</au><au>Yan, Zhanglin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECTS OF PITAVASTATIN ON MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND HIGH SENSITIVITY C REACTIVE PROTEIN IN ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION PATIENTS</atitle><jtitle>Heart (British Cardiac Society)</jtitle><addtitle>Heart</addtitle><date>2012-10</date><risdate>2012</risdate><volume>98</volume><issue>Suppl 2</issue><spage>E196</spage><epage>E196</epage><pages>E196-E196</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>Objectives To observe pitavastatin mediated inflammatory factor monocyte chemotactic protein -1 (MCP-1) and high sensitivity C-reactive protein (hs-CRP) in patient with acute ST-segment elevation myocardial infarction. Methods 198 patients with consecutive elections ST-segment elevation acute myocardial infarction were collected from January 2007 to December 2012, aged 32–88-years old, ruled out infectious diseases, cancer, collagen diseases, application of immunosuppressive drugs. All patients underwent emergency coronary intervention, were randomly divided into control group and early intervention pitavastatin group (undergoing emergency percutaneous coronary intervention 30 min to 1 h after oral administration of pitavastatin 4 mg), ELISA was used to measure the contents of MCP-1 and hs-CRP. Results (1) The levels of MCP-1 and hs-CRP in two groups increased 24 h after PCI (p&lt;0.01); (2) The levels of MCP-1 and hs-CRP in the intervention group was statistically significant compared with the control group 24 h later. Conclusions High-dose pitavastatin used in patients with Acute ST segment elevation myocardial infarction before percutaneous coronary intervention promotes MCP-1 and hs-CRP levels drop, reduce inflammatory response in patients.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><doi>10.1136/heartjnl-2012-302920k.44</doi><oa>free_for_read</oa></addata></record>
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title EFFECTS OF PITAVASTATIN ON MONOCYTE CHEMOATTRACTANT PROTEIN-1 AND HIGH SENSITIVITY C REACTIVE PROTEIN IN ACUTE ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION PATIENTS
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