Effect of serum uric acid level on blood pressure response to antihypertensive drug in male hypertensives

Effect of serum uric acid level on blood pressure response to antihypertensive drug in male hypertensives

Objective The authors explore the relationship between the serum uric acid levels and blood pressure (BP) response to antihypertensive drugs treatment in male hypertensives by a hospitalisation-based retrospective analysis. Methods According to serum uric acid (SUA) levels, 804 male inpatients with...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Heart (British Cardiac Society) 2011-10, Vol.97 (Suppl 3), p.A196-A197
Hauptverfasser: Lin, Chunjing, Yu, Huizhen, Lin, Fan, Zhu, Pengli
Format: Artikel
Sprache:eng
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page A197
container_issue Suppl 3
container_start_page A196
container_title Heart (British Cardiac Society)
container_volume 97
creator Lin, Chunjing
Yu, Huizhen
Lin, Fan
Zhu, Pengli
description Objective The authors explore the relationship between the serum uric acid levels and blood pressure (BP) response to antihypertensive drugs treatment in male hypertensives by a hospitalisation-based retrospective analysis. Methods According to serum uric acid (SUA) levels, 804 male inpatients with diagnosis of hypertension were divided into two groups, the hyperuricaemia patients (SUA>420 μmol/l, n=305) and patients with normal SUA levels (SUA
doi_str_mv 10.1136/heartjnl-2011-300867.572
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1780718388</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4020982701</sourcerecordid><originalsourceid>FETCH-LOGICAL-b2092-18416cdb07a438668e7b5889df0206c7b99da3065687c14510c942415ef631393</originalsourceid><addsrcrecordid>eNqNkMFOwzAQRC0EEqXwD5Y4p9hxYjtHqEpBVOVAQdwsx9nQhCQOdlLRvydVAHHkNKvdmR3pIYQpmVHK-NUWtOvKpgpCQmnACJFczGIRHqEJjbg8rF-Ph5nFccAJE6fozPuSEBIlkk9QschzMB22Ofbg-hr3rjBYmyLDFeygwrbBaWVthlsH3vcO8KCtbTzgzmLddMV234LroPHFDnDm-jdcNLjWFeC_F3-OTnJdebj41il6vl1s5nfB6nF5P79eBWlIkjCgMqLcZCkROmKScwkijaVMspyEhBuRJkmmGeExl8LQKKbEJFEY0RhyzihL2BRdjn9bZz968J0qbe-aoVJRIYmgkkk5uOToMs567yBXrStq7faKEnUAq37AqgNYNYJVA9ghGozRwnfw-ZvT7l1xwUSs1i9zNefrzQ19eFLLwc9Gf1qX_2_5AnaYjfo</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1780718388</pqid></control><display><type>article</type><title>Effect of serum uric acid level on blood pressure response to antihypertensive drug in male hypertensives</title><source>BMJ Journals - NESLi2</source><source>PubMed Central</source><creator>Lin, Chunjing ; Yu, Huizhen ; Lin, Fan ; Zhu, Pengli</creator><creatorcontrib>Lin, Chunjing ; Yu, Huizhen ; Lin, Fan ; Zhu, Pengli</creatorcontrib><description>Objective The authors explore the relationship between the serum uric acid levels and blood pressure (BP) response to antihypertensive drugs treatment in male hypertensives by a hospitalisation-based retrospective analysis. Methods According to serum uric acid (SUA) levels, 804 male inpatients with diagnosis of hypertension were divided into two groups, the hyperuricaemia patients (SUA&gt;420 μmol/l, n=305) and patients with normal SUA levels (SUA&lt;420 μmol/l, n=499). Multiple regression analysis models was used to examine the effect of serum uric acid levels on BP response to antihypertensive drugs during hospitalisation, after adjustment for age, diabetes mellitus, chronic kidney disease (CKD) and dyslipidaemia. Result The hypertensive patients with hyperuricaemia have higher body mass index (BMI), dyslipidaemia ratio, systolic BP (diastolic BP), serum creatinine, antihypertensive therapeutic intensity score (p&lt;0.05) and lower estimated glomerular filtration rate (eGFR), BP compliance rate (p&lt;0.05) than the normal group. Serum uric acid levels was positively correlated with BMI, total cholesterol, triglyceride, serum creatinine, systolic BP, diastolic BP (p&lt;0.05), and was negatively correlated with high-density lipoprotein cholesterol and eGFR (p&lt;0.001). In multivariable analyses adjusting for age, the mean difference from systolic BP (diastolic BP) goal, BMI, diabetes, smoking, family history, lipid metabolic disorders, hospitalisation time, antihypertension therapeutic intensity score and CKD, the male patients with hyperuricaemia have less decrease in systolic BP of 5.20 mm Hg (95% CI: 3.11–7.30 mm Hg), and have less decrease in diastolic BP of 1.55 mm Hg (95% CI 0.22 to 2.88 mm Hg). Conclusions The results suggest that serum uric acid levels could affect blood pressure response to the antihypertensive therapy in male hypertensives.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/heartjnl-2011-300867.572</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><ispartof>Heart (British Cardiac Society), 2011-10, Vol.97 (Suppl 3), p.A196-A197</ispartof><rights>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2011 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://heart.bmj.com/content/97/Suppl_3/A196.3.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://heart.bmj.com/content/97/Suppl_3/A196.3.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,23571,27924,27925,77600,77631</link.rule.ids></links><search><creatorcontrib>Lin, Chunjing</creatorcontrib><creatorcontrib>Yu, Huizhen</creatorcontrib><creatorcontrib>Lin, Fan</creatorcontrib><creatorcontrib>Zhu, Pengli</creatorcontrib><title>Effect of serum uric acid level on blood pressure response to antihypertensive drug in male hypertensives</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><description>Objective The authors explore the relationship between the serum uric acid levels and blood pressure (BP) response to antihypertensive drugs treatment in male hypertensives by a hospitalisation-based retrospective analysis. Methods According to serum uric acid (SUA) levels, 804 male inpatients with diagnosis of hypertension were divided into two groups, the hyperuricaemia patients (SUA&gt;420 μmol/l, n=305) and patients with normal SUA levels (SUA&lt;420 μmol/l, n=499). Multiple regression analysis models was used to examine the effect of serum uric acid levels on BP response to antihypertensive drugs during hospitalisation, after adjustment for age, diabetes mellitus, chronic kidney disease (CKD) and dyslipidaemia. Result The hypertensive patients with hyperuricaemia have higher body mass index (BMI), dyslipidaemia ratio, systolic BP (diastolic BP), serum creatinine, antihypertensive therapeutic intensity score (p&lt;0.05) and lower estimated glomerular filtration rate (eGFR), BP compliance rate (p&lt;0.05) than the normal group. Serum uric acid levels was positively correlated with BMI, total cholesterol, triglyceride, serum creatinine, systolic BP, diastolic BP (p&lt;0.05), and was negatively correlated with high-density lipoprotein cholesterol and eGFR (p&lt;0.001). In multivariable analyses adjusting for age, the mean difference from systolic BP (diastolic BP) goal, BMI, diabetes, smoking, family history, lipid metabolic disorders, hospitalisation time, antihypertension therapeutic intensity score and CKD, the male patients with hyperuricaemia have less decrease in systolic BP of 5.20 mm Hg (95% CI: 3.11–7.30 mm Hg), and have less decrease in diastolic BP of 1.55 mm Hg (95% CI 0.22 to 2.88 mm Hg). Conclusions The results suggest that serum uric acid levels could affect blood pressure response to the antihypertensive therapy in male hypertensives.</description><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkMFOwzAQRC0EEqXwD5Y4p9hxYjtHqEpBVOVAQdwsx9nQhCQOdlLRvydVAHHkNKvdmR3pIYQpmVHK-NUWtOvKpgpCQmnACJFczGIRHqEJjbg8rF-Ph5nFccAJE6fozPuSEBIlkk9QschzMB22Ofbg-hr3rjBYmyLDFeygwrbBaWVthlsH3vcO8KCtbTzgzmLddMV234LroPHFDnDm-jdcNLjWFeC_F3-OTnJdebj41il6vl1s5nfB6nF5P79eBWlIkjCgMqLcZCkROmKScwkijaVMspyEhBuRJkmmGeExl8LQKKbEJFEY0RhyzihL2BRdjn9bZz968J0qbe-aoVJRIYmgkkk5uOToMs567yBXrStq7faKEnUAq37AqgNYNYJVA9ghGozRwnfw-ZvT7l1xwUSs1i9zNefrzQ19eFLLwc9Gf1qX_2_5AnaYjfo</recordid><startdate>201110</startdate><enddate>201110</enddate><creator>Lin, Chunjing</creator><creator>Yu, Huizhen</creator><creator>Lin, Fan</creator><creator>Zhu, Pengli</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope></search><sort><creationdate>201110</creationdate><title>Effect of serum uric acid level on blood pressure response to antihypertensive drug in male hypertensives</title><author>Lin, Chunjing ; Yu, Huizhen ; Lin, Fan ; Zhu, Pengli</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b2092-18416cdb07a438668e7b5889df0206c7b99da3065687c14510c942415ef631393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Chunjing</creatorcontrib><creatorcontrib>Yu, Huizhen</creatorcontrib><creatorcontrib>Lin, Fan</creatorcontrib><creatorcontrib>Zhu, Pengli</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Chunjing</au><au>Yu, Huizhen</au><au>Lin, Fan</au><au>Zhu, Pengli</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of serum uric acid level on blood pressure response to antihypertensive drug in male hypertensives</atitle><jtitle>Heart (British Cardiac Society)</jtitle><addtitle>Heart</addtitle><date>2011-10</date><risdate>2011</risdate><volume>97</volume><issue>Suppl 3</issue><spage>A196</spage><epage>A197</epage><pages>A196-A197</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>Objective The authors explore the relationship between the serum uric acid levels and blood pressure (BP) response to antihypertensive drugs treatment in male hypertensives by a hospitalisation-based retrospective analysis. Methods According to serum uric acid (SUA) levels, 804 male inpatients with diagnosis of hypertension were divided into two groups, the hyperuricaemia patients (SUA&gt;420 μmol/l, n=305) and patients with normal SUA levels (SUA&lt;420 μmol/l, n=499). Multiple regression analysis models was used to examine the effect of serum uric acid levels on BP response to antihypertensive drugs during hospitalisation, after adjustment for age, diabetes mellitus, chronic kidney disease (CKD) and dyslipidaemia. Result The hypertensive patients with hyperuricaemia have higher body mass index (BMI), dyslipidaemia ratio, systolic BP (diastolic BP), serum creatinine, antihypertensive therapeutic intensity score (p&lt;0.05) and lower estimated glomerular filtration rate (eGFR), BP compliance rate (p&lt;0.05) than the normal group. Serum uric acid levels was positively correlated with BMI, total cholesterol, triglyceride, serum creatinine, systolic BP, diastolic BP (p&lt;0.05), and was negatively correlated with high-density lipoprotein cholesterol and eGFR (p&lt;0.001). In multivariable analyses adjusting for age, the mean difference from systolic BP (diastolic BP) goal, BMI, diabetes, smoking, family history, lipid metabolic disorders, hospitalisation time, antihypertension therapeutic intensity score and CKD, the male patients with hyperuricaemia have less decrease in systolic BP of 5.20 mm Hg (95% CI: 3.11–7.30 mm Hg), and have less decrease in diastolic BP of 1.55 mm Hg (95% CI 0.22 to 2.88 mm Hg). Conclusions The results suggest that serum uric acid levels could affect blood pressure response to the antihypertensive therapy in male hypertensives.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><doi>10.1136/heartjnl-2011-300867.572</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1355-6037
ispartof Heart (British Cardiac Society), 2011-10, Vol.97 (Suppl 3), p.A196-A197
issn 1355-6037
1468-201X
language eng
recordid cdi_proquest_journals_1780718388
source BMJ Journals - NESLi2; PubMed Central
title Effect of serum uric acid level on blood pressure response to antihypertensive drug in male hypertensives
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T14%3A55%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Effect%20of%20serum%20uric%20acid%20level%20on%20blood%20pressure%20response%20to%20antihypertensive%20drug%20in%20male%20hypertensives&rft.jtitle=Heart%20(British%20Cardiac%20Society)&rft.au=Lin,%20Chunjing&rft.date=2011-10&rft.volume=97&rft.issue=Suppl%203&rft.spage=A196&rft.epage=A197&rft.pages=A196-A197&rft.issn=1355-6037&rft.eissn=1468-201X&rft_id=info:doi/10.1136/heartjnl-2011-300867.572&rft_dat=%3Cproquest_cross%3E4020982701%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1780718388&rft_id=info:pmid/&rfr_iscdi=true