e0325 Influence of probucol on endothelial dependent vasodilation reaction in patients with acute coronary syndrome

e0325 Influence of probucol on endothelial dependent vasodilation reaction in patients with acute coronary syndrome

Objective The study tested the antioxidant probucol for endothelial dependent vasodilation reaction in the patients of ACS after received therapy. Methods 51 ACS patients were divided randomly into a probucol treatment group (p) and a routine treatment group (C). Oxidised low-density lipoprotein (ox...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Heart (British Cardiac Society) 2010-10, Vol.96 (Suppl 3), p.A101-A101
Hauptverfasser: Dong, Hong-Mei, Huang, Lan, Song, Yao-Ming, Li, Ai-Min, Jin, Jun, Zhao, Gang, Lin, Chun-Mei, Tao, Chun-rong
Format: Artikel
Sprache:eng
Schlagworte:
Acute coronary syndrome
oxidative low density lipoprotein
probucol
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page A101
container_issue Suppl 3
container_start_page A101
container_title Heart (British Cardiac Society)
container_volume 96
creator Dong, Hong-Mei
Huang, Lan
Song, Yao-Ming
Li, Ai-Min
Jin, Jun
Zhao, Gang
Lin, Chun-Mei
Tao, Chun-rong
description Objective The study tested the antioxidant probucol for endothelial dependent vasodilation reaction in the patients of ACS after received therapy. Methods 51 ACS patients were divided randomly into a probucol treatment group (p) and a routine treatment group (C). Oxidised low-density lipoprotein (ox-LDL) was measured in peripheral blood by Sandwich ELISE method. The brachial arterial hyperaemia-induced flow mediated dilation (FMD) and sublingual nitroglycerin (NTG) mediated vasodilation were measured by high resolution ultrasound. These variables were analysed after received probucol 3 months. Results The level of FMD with probucol treatment group was significantly increased after 3 months compared to pretreamented (p
doi_str_mv 10.1136/hrt.2010.208967.325
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1780712531</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4020895391</sourcerecordid><originalsourceid>FETCH-LOGICAL-b1945-6da998894ef7528568c30d9be93b71f6e22e70138a536bf89d0f983d7d58f6f43</originalsourceid><addsrcrecordid>eNqNkMtu1DAUhiMEUkvhCbqxxDpTO45vSzRAW_WChApiZznxsSZDxh7spJcdG16UJ-kpQV2zOhd9_7n8VXXM6IoxLk82eVo1FKuGaiPVijfiRXXIWqlrbH9_iTkXopaUq4PqdSlbSmlrtDysZqAI__n1-zyGcYbYA0mB7HPq5j6NJEUC0adpA-PgRuJhjyXEidy6kvwwumlAJIPr_yZDJHtsIVDI3TBtiOvnCUifcoouP5DyEH1OO3hTvQpuLPD2Xzyqvn76eLM-qy8_n56v31_WHTMt3uudMVqbFoISjRZS95x604HhnWJBQtOAooxrJ7jsgjaeBqO5V17oIEPLj6p3y1x86OcMZbLbNOeIKy1TmirWCM6Q4gvV51RKhmD3edjhvZZR--SvRX_tk7928deiZaiqF9VQJrh_lrj8w0rFlbDX39ZWyw9Xp19uLuwZ8quF73bb_1rwCJ-IjiE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1780712531</pqid></control><display><type>article</type><title>e0325 Influence of probucol on endothelial dependent vasodilation reaction in patients with acute coronary syndrome</title><source>BMJ Journals - NESLi2</source><source>PubMed Central</source><creator>Dong, Hong-Mei ; Huang, Lan ; Song, Yao-Ming ; Li, Ai-Min ; Jin, Jun ; Zhao, Gang ; Lin, Chun-Mei ; Tao, Chun-rong</creator><creatorcontrib>Dong, Hong-Mei ; Huang, Lan ; Song, Yao-Ming ; Li, Ai-Min ; Jin, Jun ; Zhao, Gang ; Lin, Chun-Mei ; Tao, Chun-rong</creatorcontrib><description>Objective The study tested the antioxidant probucol for endothelial dependent vasodilation reaction in the patients of ACS after received therapy. Methods 51 ACS patients were divided randomly into a probucol treatment group (p) and a routine treatment group (C). Oxidised low-density lipoprotein (ox-LDL) was measured in peripheral blood by Sandwich ELISE method. The brachial arterial hyperaemia-induced flow mediated dilation (FMD) and sublingual nitroglycerin (NTG) mediated vasodilation were measured by high resolution ultrasound. These variables were analysed after received probucol 3 months. Results The level of FMD with probucol treatment group was significantly increased after 3 months compared to pretreamented (p&lt;0.05), while the level of ox-LDL in peripheral blood in ACS patients was markedly diseased (p&lt;0.01). The FMD with probucol treatment group was significantly increased compared to ACS routine treatment group (p&lt;0.05), while the level of ox-LDL was markedly desaesed (p&lt;0.01). The linear correlation analysis showed that plasma ox-LDL was a negative correlation with FMD in after treatmented patients by probucol with ACS (r=−0.517, p&lt;0.001). Conclusions It was important that vascular endothelial function and endothelial dependent vasodilation reaction may be improved in the ACS patients of after the antioxidant probucol therapy.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/hrt.2010.208967.325</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>Acute coronary syndrome ; oxidative low density lipoprotein ; probucol</subject><ispartof>Heart (British Cardiac Society), 2010-10, Vol.96 (Suppl 3), p.A101-A101</ispartof><rights>2010, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2010 (c) 2010, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://heart.bmj.com/content/96/Suppl_3/A101.1.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://heart.bmj.com/content/96/Suppl_3/A101.1.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,23571,27924,27925,77600,77631</link.rule.ids></links><search><creatorcontrib>Dong, Hong-Mei</creatorcontrib><creatorcontrib>Huang, Lan</creatorcontrib><creatorcontrib>Song, Yao-Ming</creatorcontrib><creatorcontrib>Li, Ai-Min</creatorcontrib><creatorcontrib>Jin, Jun</creatorcontrib><creatorcontrib>Zhao, Gang</creatorcontrib><creatorcontrib>Lin, Chun-Mei</creatorcontrib><creatorcontrib>Tao, Chun-rong</creatorcontrib><title>e0325 Influence of probucol on endothelial dependent vasodilation reaction in patients with acute coronary syndrome</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><description>Objective The study tested the antioxidant probucol for endothelial dependent vasodilation reaction in the patients of ACS after received therapy. Methods 51 ACS patients were divided randomly into a probucol treatment group (p) and a routine treatment group (C). Oxidised low-density lipoprotein (ox-LDL) was measured in peripheral blood by Sandwich ELISE method. The brachial arterial hyperaemia-induced flow mediated dilation (FMD) and sublingual nitroglycerin (NTG) mediated vasodilation were measured by high resolution ultrasound. These variables were analysed after received probucol 3 months. Results The level of FMD with probucol treatment group was significantly increased after 3 months compared to pretreamented (p&lt;0.05), while the level of ox-LDL in peripheral blood in ACS patients was markedly diseased (p&lt;0.01). The FMD with probucol treatment group was significantly increased compared to ACS routine treatment group (p&lt;0.05), while the level of ox-LDL was markedly desaesed (p&lt;0.01). The linear correlation analysis showed that plasma ox-LDL was a negative correlation with FMD in after treatmented patients by probucol with ACS (r=−0.517, p&lt;0.001). Conclusions It was important that vascular endothelial function and endothelial dependent vasodilation reaction may be improved in the ACS patients of after the antioxidant probucol therapy.</description><subject>Acute coronary syndrome</subject><subject>oxidative low density lipoprotein</subject><subject>probucol</subject><issn>1355-6037</issn><issn>1468-201X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkMtu1DAUhiMEUkvhCbqxxDpTO45vSzRAW_WChApiZznxsSZDxh7spJcdG16UJ-kpQV2zOhd9_7n8VXXM6IoxLk82eVo1FKuGaiPVijfiRXXIWqlrbH9_iTkXopaUq4PqdSlbSmlrtDysZqAI__n1-zyGcYbYA0mB7HPq5j6NJEUC0adpA-PgRuJhjyXEidy6kvwwumlAJIPr_yZDJHtsIVDI3TBtiOvnCUifcoouP5DyEH1OO3hTvQpuLPD2Xzyqvn76eLM-qy8_n56v31_WHTMt3uudMVqbFoISjRZS95x604HhnWJBQtOAooxrJ7jsgjaeBqO5V17oIEPLj6p3y1x86OcMZbLbNOeIKy1TmirWCM6Q4gvV51RKhmD3edjhvZZR--SvRX_tk7928deiZaiqF9VQJrh_lrj8w0rFlbDX39ZWyw9Xp19uLuwZ8quF73bb_1rwCJ-IjiE</recordid><startdate>201010</startdate><enddate>201010</enddate><creator>Dong, Hong-Mei</creator><creator>Huang, Lan</creator><creator>Song, Yao-Ming</creator><creator>Li, Ai-Min</creator><creator>Jin, Jun</creator><creator>Zhao, Gang</creator><creator>Lin, Chun-Mei</creator><creator>Tao, Chun-rong</creator><general>BMJ Publishing Group Ltd and British Cardiovascular Society</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>201010</creationdate><title>e0325 Influence of probucol on endothelial dependent vasodilation reaction in patients with acute coronary syndrome</title><author>Dong, Hong-Mei ; Huang, Lan ; Song, Yao-Ming ; Li, Ai-Min ; Jin, Jun ; Zhao, Gang ; Lin, Chun-Mei ; Tao, Chun-rong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b1945-6da998894ef7528568c30d9be93b71f6e22e70138a536bf89d0f983d7d58f6f43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Acute coronary syndrome</topic><topic>oxidative low density lipoprotein</topic><topic>probucol</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dong, Hong-Mei</creatorcontrib><creatorcontrib>Huang, Lan</creatorcontrib><creatorcontrib>Song, Yao-Ming</creatorcontrib><creatorcontrib>Li, Ai-Min</creatorcontrib><creatorcontrib>Jin, Jun</creatorcontrib><creatorcontrib>Zhao, Gang</creatorcontrib><creatorcontrib>Lin, Chun-Mei</creatorcontrib><creatorcontrib>Tao, Chun-rong</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dong, Hong-Mei</au><au>Huang, Lan</au><au>Song, Yao-Ming</au><au>Li, Ai-Min</au><au>Jin, Jun</au><au>Zhao, Gang</au><au>Lin, Chun-Mei</au><au>Tao, Chun-rong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>e0325 Influence of probucol on endothelial dependent vasodilation reaction in patients with acute coronary syndrome</atitle><jtitle>Heart (British Cardiac Society)</jtitle><addtitle>Heart</addtitle><date>2010-10</date><risdate>2010</risdate><volume>96</volume><issue>Suppl 3</issue><spage>A101</spage><epage>A101</epage><pages>A101-A101</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>Objective The study tested the antioxidant probucol for endothelial dependent vasodilation reaction in the patients of ACS after received therapy. Methods 51 ACS patients were divided randomly into a probucol treatment group (p) and a routine treatment group (C). Oxidised low-density lipoprotein (ox-LDL) was measured in peripheral blood by Sandwich ELISE method. The brachial arterial hyperaemia-induced flow mediated dilation (FMD) and sublingual nitroglycerin (NTG) mediated vasodilation were measured by high resolution ultrasound. These variables were analysed after received probucol 3 months. Results The level of FMD with probucol treatment group was significantly increased after 3 months compared to pretreamented (p&lt;0.05), while the level of ox-LDL in peripheral blood in ACS patients was markedly diseased (p&lt;0.01). The FMD with probucol treatment group was significantly increased compared to ACS routine treatment group (p&lt;0.05), while the level of ox-LDL was markedly desaesed (p&lt;0.01). The linear correlation analysis showed that plasma ox-LDL was a negative correlation with FMD in after treatmented patients by probucol with ACS (r=−0.517, p&lt;0.001). Conclusions It was important that vascular endothelial function and endothelial dependent vasodilation reaction may be improved in the ACS patients of after the antioxidant probucol therapy.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><doi>10.1136/hrt.2010.208967.325</doi><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1355-6037
ispartof Heart (British Cardiac Society), 2010-10, Vol.96 (Suppl 3), p.A101-A101
issn 1355-6037
1468-201X
language eng
recordid cdi_proquest_journals_1780712531
source BMJ Journals - NESLi2; PubMed Central
subjects Acute coronary syndrome
oxidative low density lipoprotein
probucol
title e0325 Influence of probucol on endothelial dependent vasodilation reaction in patients with acute coronary syndrome
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T14%3A04%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=e0325%E2%80%85Influence%20of%20probucol%20on%20endothelial%20dependent%20vasodilation%20reaction%20in%20patients%20with%20acute%20coronary%20syndrome&rft.jtitle=Heart%20(British%20Cardiac%20Society)&rft.au=Dong,%20Hong-Mei&rft.date=2010-10&rft.volume=96&rft.issue=Suppl%203&rft.spage=A101&rft.epage=A101&rft.pages=A101-A101&rft.issn=1355-6037&rft.eissn=1468-201X&rft_id=info:doi/10.1136/hrt.2010.208967.325&rft_dat=%3Cproquest_cross%3E4020895391%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1780712531&rft_id=info:pmid/&rfr_iscdi=true