e0026 Association between the M235T, T174M polymorphism of the angiotensinogen gene and left ventricular hypertrophy in essential hypertension in Kazakans
Objective To investigate whether the M235T, T174M polymorphisms of the angiotensinogen gene were associated with left ventricular hypertrophy (LVH) in Xinjiang Kazakans with essential hypertension. Methods 86 patients with essential hypertension and left ventricular hypertrophy and 95 patients with...
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| Veröffentlicht in: | Heart (British Cardiac Society) 2010-10, Vol.96 (Suppl 3), p.A9-A9 |
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| creator | Junli, Zuo Nanfang, Li Delian, Zhang Ling, Zhou Tao, Li |
| description | Objective To investigate whether the M235T, T174M polymorphisms of the angiotensinogen gene were associated with left ventricular hypertrophy (LVH) in Xinjiang Kazakans with essential hypertension. Methods 86 patients with essential hypertension and left ventricular hypertrophy and 95 patients with essential hypertension and non-left ventricular hypertrophy. Left ventricular hypertrophy was evaluated by the electrocardiography voltage criteria and the Romhilt-Estespoint-score system. The AGT gene M235T, T174M polymorphisms were amplified by PCR and analysed by RFLP. Results (1) The genotype distributions of the M235T and T174M in both groups were in agreement with Hardy–Weinberg equilibrium. (2) The frequencies of the AGT genotypes and alleles were not significantly different between LVH and NLVH with hypertension. (3) When analysing the frequencies of genotypes and alleles of M235T according to gender (p>0.05), no significant differences were found between LVH and NLVH. However, we found a significant difference in frequencies of genotypes and alleles of T174M in NLVH group according to gender. Conclusion There are no associations between M235T genotype and T174M genotype with the presence of LVH in this study. |
| doi_str_mv | 10.1136/hrt.2010.208967.26 |
| format | Article |
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Methods 86 patients with essential hypertension and left ventricular hypertrophy and 95 patients with essential hypertension and non-left ventricular hypertrophy. Left ventricular hypertrophy was evaluated by the electrocardiography voltage criteria and the Romhilt-Estespoint-score system. The AGT gene M235T, T174M polymorphisms were amplified by PCR and analysed by RFLP. Results (1) The genotype distributions of the M235T and T174M in both groups were in agreement with Hardy–Weinberg equilibrium. (2) The frequencies of the AGT genotypes and alleles were not significantly different between LVH and NLVH with hypertension. (3) When analysing the frequencies of genotypes and alleles of M235T according to gender (p>0.05), no significant differences were found between LVH and NLVH. However, we found a significant difference in frequencies of genotypes and alleles of T174M in NLVH group according to gender. Conclusion There are no associations between M235T genotype and T174M genotype with the presence of LVH in this study.</description><identifier>ISSN: 1355-6037</identifier><identifier>EISSN: 1468-201X</identifier><identifier>DOI: 10.1136/hrt.2010.208967.26</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Cardiovascular Society</publisher><subject>Angiotensinogen gene ; essential hypertension ; left ventricular hypertrophy ; polymorphism</subject><ispartof>Heart (British Cardiac Society), 2010-10, Vol.96 (Suppl 3), p.A9-A9</ispartof><rights>2010, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2010 (c) 2010, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b2406-95357261d6b6458677bcdf8dafc6ec2d1351c14d1aac47efb8c7a023da61fa993</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://heart.bmj.com/content/96/Suppl_3/A9.1.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://heart.bmj.com/content/96/Suppl_3/A9.1.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3182,23551,27903,27904,77346,77377</link.rule.ids></links><search><creatorcontrib>Junli, Zuo</creatorcontrib><creatorcontrib>Nanfang, Li</creatorcontrib><creatorcontrib>Delian, Zhang</creatorcontrib><creatorcontrib>Ling, Zhou</creatorcontrib><creatorcontrib>Tao, Li</creatorcontrib><title>e0026 Association between the M235T, T174M polymorphism of the angiotensinogen gene and left ventricular hypertrophy in essential hypertension in Kazakans</title><title>Heart (British Cardiac Society)</title><addtitle>Heart</addtitle><description>Objective To investigate whether the M235T, T174M polymorphisms of the angiotensinogen gene were associated with left ventricular hypertrophy (LVH) in Xinjiang Kazakans with essential hypertension. Methods 86 patients with essential hypertension and left ventricular hypertrophy and 95 patients with essential hypertension and non-left ventricular hypertrophy. Left ventricular hypertrophy was evaluated by the electrocardiography voltage criteria and the Romhilt-Estespoint-score system. The AGT gene M235T, T174M polymorphisms were amplified by PCR and analysed by RFLP. Results (1) The genotype distributions of the M235T and T174M in both groups were in agreement with Hardy–Weinberg equilibrium. (2) The frequencies of the AGT genotypes and alleles were not significantly different between LVH and NLVH with hypertension. (3) When analysing the frequencies of genotypes and alleles of M235T according to gender (p>0.05), no significant differences were found between LVH and NLVH. However, we found a significant difference in frequencies of genotypes and alleles of T174M in NLVH group according to gender. 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Nanfang, Li ; Delian, Zhang ; Ling, Zhou ; Tao, Li</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b2406-95357261d6b6458677bcdf8dafc6ec2d1351c14d1aac47efb8c7a023da61fa993</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Angiotensinogen gene</topic><topic>essential hypertension</topic><topic>left ventricular hypertrophy</topic><topic>polymorphism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Junli, Zuo</creatorcontrib><creatorcontrib>Nanfang, Li</creatorcontrib><creatorcontrib>Delian, Zhang</creatorcontrib><creatorcontrib>Ling, Zhou</creatorcontrib><creatorcontrib>Tao, Li</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Heart (British Cardiac Society)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Junli, Zuo</au><au>Nanfang, Li</au><au>Delian, Zhang</au><au>Ling, Zhou</au><au>Tao, Li</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>e0026 Association between the M235T, T174M polymorphism of the angiotensinogen gene and left ventricular hypertrophy in essential hypertension in Kazakans</atitle><jtitle>Heart (British Cardiac Society)</jtitle><addtitle>Heart</addtitle><date>2010-10</date><risdate>2010</risdate><volume>96</volume><issue>Suppl 3</issue><spage>A9</spage><epage>A9</epage><pages>A9-A9</pages><issn>1355-6037</issn><eissn>1468-201X</eissn><abstract>Objective To investigate whether the M235T, T174M polymorphisms of the angiotensinogen gene were associated with left ventricular hypertrophy (LVH) in Xinjiang Kazakans with essential hypertension. Methods 86 patients with essential hypertension and left ventricular hypertrophy and 95 patients with essential hypertension and non-left ventricular hypertrophy. Left ventricular hypertrophy was evaluated by the electrocardiography voltage criteria and the Romhilt-Estespoint-score system. The AGT gene M235T, T174M polymorphisms were amplified by PCR and analysed by RFLP. Results (1) The genotype distributions of the M235T and T174M in both groups were in agreement with Hardy–Weinberg equilibrium. (2) The frequencies of the AGT genotypes and alleles were not significantly different between LVH and NLVH with hypertension. (3) When analysing the frequencies of genotypes and alleles of M235T according to gender (p>0.05), no significant differences were found between LVH and NLVH. However, we found a significant difference in frequencies of genotypes and alleles of T174M in NLVH group according to gender. Conclusion There are no associations between M235T genotype and T174M genotype with the presence of LVH in this study.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Cardiovascular Society</pub><doi>10.1136/hrt.2010.208967.26</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Angiotensinogen gene essential hypertension left ventricular hypertrophy polymorphism |
| title | e0026 Association between the M235T, T174M polymorphism of the angiotensinogen gene and left ventricular hypertrophy in essential hypertension in Kazakans |
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