Natural killer cell hyporesponsiveness and impaired development in a CD247-deficient patient

To the Editor: The analysis of single gene defects in patients with primary immunodeficiency has provided important insights into the normal physiology of the immune system and is particularly valuable in those instances where the human and murine immune systems are different.1 CD247 (T-cell recepto...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2016-03, Vol.137 (3), p.942-945.e4
Hauptverfasser:	Valés-Gómez, Mar, PhD, Esteso, Gloria, PhD, Aydogmus, Cigdem, MD, Blázquez-Moreno, Alfonso, BSc, Marín, Ana V., BSc, Briones, Alejandro C., BSc, Garcillán, Beatriz, PhD, García-Cuesta, Eva-María, BSc, López Cobo, Sheila, BSc, Haskologlu, Sule, MD, Moraru, Manuela, MD, Cipe, Funda, MD, Dobbs, Kerry, BS, Dogu, Figen, MD, Parolini, Silvia, PhD, Notarangelo, Luigi D., MD, Vilches, Carlos, MD, PhD, Recio, Maria J., PhD, Regueiro, José R., PhD, Ikinciogullari, Aydan, MD, Reyburn, Hugh T., PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Allergy and Immunology Biopsy CD3 Complex - genetics Cytotoxicity Gastroesophageal reflux Gene Expression Genotype Genotype & phenotype Humans Immune system Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Lymphocyte receptors Rodents Sequence Deletion T cell receptors Urine
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