Zincmethylphyrins and coproporphyrins, novel growth factors released by Sphingopyxis sp., enable laboratory cultivation of previously uncultured Leucobacter sp. through interspecies mutualism
We have identified coproporphyrins including structurally new zincmethylphyrins I and III as growth factors A–F for the previously uncultured bacterial strain, Leucobacter sp. ASN212, from a supernatant of 210 l of Sphingopyxis sp. GF9 culture. Growth factors A–F induced significant growth of strain...
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| Veröffentlicht in: | Journal of antibiotics 2016-02, Vol.69 (2), p.97-103 |
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| creator | Bhuiyan, Mohammad Nazrul Islam Takai, Ryogo Mitsuhashi, Shinya Shigetomi, Kengo Tanaka, Yasuhiro Kamagata, Yoichi Ubukata, Makoto |
| description | We have identified coproporphyrins including structurally new zincmethylphyrins I and III as growth factors A–F for the previously uncultured bacterial strain,
Leucobacter
sp. ASN212, from a supernatant of 210 l of
Sphingopyxis
sp. GF9 culture. Growth factors A–F induced significant growth of strain ASN212 at the concentrations of picomolar to nanomolar which would otherwise be unculturable in liquid medium or on agar plate. More interestingly, we found that the growth factors functioned as self-toxic compounds for the growth-factor producing strain GF9 at the picomolar to nanomolar levels. As a variety of bacteria could potentially produce coproporphyrins, our findings suggest that these compounds function as a novel class of signal molecules across a boundary at phylum level in the complex bacterial communities. |
| doi_str_mv | 10.1038/ja.2015.87 |
| format | Article |
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Leucobacter
sp. ASN212, from a supernatant of 210 l of
Sphingopyxis
sp. GF9 culture. Growth factors A–F induced significant growth of strain ASN212 at the concentrations of picomolar to nanomolar which would otherwise be unculturable in liquid medium or on agar plate. More interestingly, we found that the growth factors functioned as self-toxic compounds for the growth-factor producing strain GF9 at the picomolar to nanomolar levels. As a variety of bacteria could potentially produce coproporphyrins, our findings suggest that these compounds function as a novel class of signal molecules across a boundary at phylum level in the complex bacterial communities.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.1038/ja.2015.87</identifier><identifier>PMID: 26306814</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>101/58 ; 631/154/349 ; 631/326/2565 ; 631/92/613 ; 704/158/2463 ; 704/158/855 ; Actinobacteria - drug effects ; Actinobacteria - growth & development ; Actinobacteria - physiology ; Bacteriology ; Biomedical and Life Sciences ; Bioorganic Chemistry ; Coproporphyrins - isolation & purification ; Coproporphyrins - metabolism ; Culture Media - chemistry ; Growth factors ; Intercellular Signaling Peptides and Proteins - isolation & purification ; Intercellular Signaling Peptides and Proteins - metabolism ; Life Sciences ; Medicinal Chemistry ; Microbiology ; Models, Molecular ; Molecular Structure ; Mutualism ; Organic Chemistry ; original-article ; Sphingomonadaceae - metabolism ; Sphingomonadaceae - physiology ; Symbiosis</subject><ispartof>Journal of antibiotics, 2016-02, Vol.69 (2), p.97-103</ispartof><rights>Japan Antibiotics Research Association 2016</rights><rights>Copyright Nature Publishing Group Feb 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c521t-2abfd2701cf57fa508eeec7246a1771b3c655c821308b08343e24835a5bcc9343</citedby><cites>FETCH-LOGICAL-c521t-2abfd2701cf57fa508eeec7246a1771b3c655c821308b08343e24835a5bcc9343</cites><orcidid>0000-0002-2445-6091</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26306814$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhuiyan, Mohammad Nazrul Islam</creatorcontrib><creatorcontrib>Takai, Ryogo</creatorcontrib><creatorcontrib>Mitsuhashi, Shinya</creatorcontrib><creatorcontrib>Shigetomi, Kengo</creatorcontrib><creatorcontrib>Tanaka, Yasuhiro</creatorcontrib><creatorcontrib>Kamagata, Yoichi</creatorcontrib><creatorcontrib>Ubukata, Makoto</creatorcontrib><title>Zincmethylphyrins and coproporphyrins, novel growth factors released by Sphingopyxis sp., enable laboratory cultivation of previously uncultured Leucobacter sp. through interspecies mutualism</title><title>Journal of antibiotics</title><addtitle>J Antibiot</addtitle><addtitle>J Antibiot (Tokyo)</addtitle><description>We have identified coproporphyrins including structurally new zincmethylphyrins I and III as growth factors A–F for the previously uncultured bacterial strain,
Leucobacter
sp. ASN212, from a supernatant of 210 l of
Sphingopyxis
sp. GF9 culture. Growth factors A–F induced significant growth of strain ASN212 at the concentrations of picomolar to nanomolar which would otherwise be unculturable in liquid medium or on agar plate. More interestingly, we found that the growth factors functioned as self-toxic compounds for the growth-factor producing strain GF9 at the picomolar to nanomolar levels. As a variety of bacteria could potentially produce coproporphyrins, our findings suggest that these compounds function as a novel class of signal molecules across a boundary at phylum level in the complex bacterial communities.</description><subject>101/58</subject><subject>631/154/349</subject><subject>631/326/2565</subject><subject>631/92/613</subject><subject>704/158/2463</subject><subject>704/158/855</subject><subject>Actinobacteria - drug effects</subject><subject>Actinobacteria - growth & development</subject><subject>Actinobacteria - physiology</subject><subject>Bacteriology</subject><subject>Biomedical and Life Sciences</subject><subject>Bioorganic Chemistry</subject><subject>Coproporphyrins - isolation & purification</subject><subject>Coproporphyrins - metabolism</subject><subject>Culture Media - chemistry</subject><subject>Growth factors</subject><subject>Intercellular Signaling Peptides and Proteins - isolation & purification</subject><subject>Intercellular Signaling Peptides and Proteins - metabolism</subject><subject>Life Sciences</subject><subject>Medicinal Chemistry</subject><subject>Microbiology</subject><subject>Models, Molecular</subject><subject>Molecular Structure</subject><subject>Mutualism</subject><subject>Organic Chemistry</subject><subject>original-article</subject><subject>Sphingomonadaceae - metabolism</subject><subject>Sphingomonadaceae - physiology</subject><subject>Symbiosis</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkcuKFDEUhoM4OO3oxgeQgDudapPUJZnlMHiDBhczbtwUqfSprjSpJObSWk83r2aabkVwFXLOx_fD-RF6Rcmaklq838s1I7RdC_4EragQtKJNd_MUrQhhtBKCkUv0PMY9ITWvuXiGLllXk07QZoUev2urZkjTYvy0BG0jlnaLlfPBeRfOs2ts3QEM3gX3M014lCq5EHEAAzLCFg8LvveTtjvnl1864ujX1xisHAxgIwcXZOEXrLJJ-iCTdha7EfsAB-1yNAvO9rjLobg2kJUbSgKEowenKbi8m7C2ZRI9KA0RzzllaXScX6CLUZoIL8_vFfr28cPD3edq8_XTl7vbTaVaRlPF5DBuGSdUjS0fZUsEACjOmk5SzulQq65tlWC0JmIgom5qYI2oW9kOSt2U7xV6c_KWu_zIEFO_dznYEtlTLkjHOs5Iod6eKBVcjAHG3gc9y7D0lPTHrvq97I9d9YIX-PVZmYcZtn_RP-UU4N0JiGVldxD-yfxf9xsh5qO1</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Bhuiyan, Mohammad Nazrul Islam</creator><creator>Takai, Ryogo</creator><creator>Mitsuhashi, Shinya</creator><creator>Shigetomi, Kengo</creator><creator>Tanaka, Yasuhiro</creator><creator>Kamagata, Yoichi</creator><creator>Ubukata, Makoto</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><orcidid>https://orcid.org/0000-0002-2445-6091</orcidid></search><sort><creationdate>20160201</creationdate><title>Zincmethylphyrins and coproporphyrins, novel growth factors released by Sphingopyxis sp., enable laboratory cultivation of previously uncultured Leucobacter sp. through interspecies mutualism</title><author>Bhuiyan, Mohammad Nazrul Islam ; Takai, Ryogo ; Mitsuhashi, Shinya ; Shigetomi, Kengo ; Tanaka, Yasuhiro ; Kamagata, Yoichi ; Ubukata, Makoto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c521t-2abfd2701cf57fa508eeec7246a1771b3c655c821308b08343e24835a5bcc9343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>101/58</topic><topic>631/154/349</topic><topic>631/326/2565</topic><topic>631/92/613</topic><topic>704/158/2463</topic><topic>704/158/855</topic><topic>Actinobacteria - drug effects</topic><topic>Actinobacteria - growth & development</topic><topic>Actinobacteria - physiology</topic><topic>Bacteriology</topic><topic>Biomedical and Life Sciences</topic><topic>Bioorganic Chemistry</topic><topic>Coproporphyrins - isolation & purification</topic><topic>Coproporphyrins - metabolism</topic><topic>Culture Media - chemistry</topic><topic>Growth factors</topic><topic>Intercellular Signaling Peptides and Proteins - isolation & purification</topic><topic>Intercellular Signaling Peptides and Proteins - metabolism</topic><topic>Life Sciences</topic><topic>Medicinal Chemistry</topic><topic>Microbiology</topic><topic>Models, Molecular</topic><topic>Molecular Structure</topic><topic>Mutualism</topic><topic>Organic Chemistry</topic><topic>original-article</topic><topic>Sphingomonadaceae - metabolism</topic><topic>Sphingomonadaceae - physiology</topic><topic>Symbiosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bhuiyan, Mohammad Nazrul Islam</creatorcontrib><creatorcontrib>Takai, Ryogo</creatorcontrib><creatorcontrib>Mitsuhashi, Shinya</creatorcontrib><creatorcontrib>Shigetomi, Kengo</creatorcontrib><creatorcontrib>Tanaka, Yasuhiro</creatorcontrib><creatorcontrib>Kamagata, Yoichi</creatorcontrib><creatorcontrib>Ubukata, Makoto</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bhuiyan, Mohammad Nazrul Islam</au><au>Takai, Ryogo</au><au>Mitsuhashi, Shinya</au><au>Shigetomi, Kengo</au><au>Tanaka, Yasuhiro</au><au>Kamagata, Yoichi</au><au>Ubukata, Makoto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Zincmethylphyrins and coproporphyrins, novel growth factors released by Sphingopyxis sp., enable laboratory cultivation of previously uncultured Leucobacter sp. through interspecies mutualism</atitle><jtitle>Journal of antibiotics</jtitle><stitle>J Antibiot</stitle><addtitle>J Antibiot (Tokyo)</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>69</volume><issue>2</issue><spage>97</spage><epage>103</epage><pages>97-103</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>We have identified coproporphyrins including structurally new zincmethylphyrins I and III as growth factors A–F for the previously uncultured bacterial strain,
Leucobacter
sp. ASN212, from a supernatant of 210 l of
Sphingopyxis
sp. GF9 culture. Growth factors A–F induced significant growth of strain ASN212 at the concentrations of picomolar to nanomolar which would otherwise be unculturable in liquid medium or on agar plate. More interestingly, we found that the growth factors functioned as self-toxic compounds for the growth-factor producing strain GF9 at the picomolar to nanomolar levels. As a variety of bacteria could potentially produce coproporphyrins, our findings suggest that these compounds function as a novel class of signal molecules across a boundary at phylum level in the complex bacterial communities.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>26306814</pmid><doi>10.1038/ja.2015.87</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-2445-6091</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 101/58 631/154/349 631/326/2565 631/92/613 704/158/2463 704/158/855 Actinobacteria - drug effects Actinobacteria - growth & development Actinobacteria - physiology Bacteriology Biomedical and Life Sciences Bioorganic Chemistry Coproporphyrins - isolation & purification Coproporphyrins - metabolism Culture Media - chemistry Growth factors Intercellular Signaling Peptides and Proteins - isolation & purification Intercellular Signaling Peptides and Proteins - metabolism Life Sciences Medicinal Chemistry Microbiology Models, Molecular Molecular Structure Mutualism Organic Chemistry original-article Sphingomonadaceae - metabolism Sphingomonadaceae - physiology Symbiosis |
| title | Zincmethylphyrins and coproporphyrins, novel growth factors released by Sphingopyxis sp., enable laboratory cultivation of previously uncultured Leucobacter sp. through interspecies mutualism |
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