Xenon offers stable haemodynamics after global hypoxic-ischaemia in newborn pigs

Xenon offers stable haemodynamics after global hypoxic-ischaemia in newborn pigs

Background Perinatal hypoxic ischaemic encephalopathy (HIE) causes cardiac dysfunction/hypotension. Xenon (Xe) anaesthesia offers short term stable haemodynamics in human adults/mature animals with cardiovascular risk. We studied long term haemodynamics during 50% xenon inhalation at normothermia (N...

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Veröffentlicht in:Archives of disease in childhood. Fetal and neonatal edition 2011-06, Vol.96 (Suppl 1), p.Fa6-Fa6
Hauptverfasser: Chakkarapani, E, Liu, X, Dingley, J, Thoresen, M
Format: Artikel
Sprache:eng
Schlagworte:
Anesthesia
Blood pressure
Health risks
Heart rate
Hypothermia
Hypoxia
Inhalation
Swine
Ventilation
Xenon
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Zusammenfassung:Background Perinatal hypoxic ischaemic encephalopathy (HIE) causes cardiac dysfunction/hypotension. Xenon (Xe) anaesthesia offers short term stable haemodynamics in human adults/mature animals with cardiovascular risk. We studied long term haemodynamics during 50% xenon inhalation at normothermia (NT 38.5°C) or hypothermia (HT 33.5°C) in a newborn global Hypoxic-Ischaemic (HI) pig model. Methods 98 newborn pigs were ventilated under inhalational anaesthesia, given a 45 min global HI insult (inhaled oxygen fraction reduced until amplitude integrated electroencephalogram
ISSN:1359-2998
1468-2052
DOI:10.1136/adc.2011.300160.17