Bevacizumab for newly diagnosed pleural mesothelioma in the Mesothelioma Avastin Cisplatin Pemetrexed Study (MAPS): a randomised, controlled, open-label, phase 3 trial

Summary Background Malignant pleural mesothelioma is an aggressive cancer with poor prognosis, linked to occupational asbestos exposure. Vascular endothelial growth factor is a key mitogen for malignant pleural mesothelioma cells, therefore targeting of vascular endothelial growth factor might prove...

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Veröffentlicht in:	The Lancet (British edition) 2016-04, Vol.387 (10026), p.1405-1414
Hauptverfasser:	Zalcman, Gérard, Prof, Mazieres, Julien, Prof, Margery, Jacques, MD, Greillier, Laurent, MD, Audigier-Valette, Clarisse, MD, Moro-Sibilot, Denis, Prof, Molinier, Olivier, MD, Corre, Romain, MD, Monnet, Isabelle, MD, Gounant, Valérie, MD, Rivière, Frédéric, MD, Janicot, Henri, MD, Gervais, Radj, MD, Locher, Chrystèle, MD, Milleron, Bernard, MD, Tran, Quan, MSc, Lebitasy, Marie-Paule, MD, Morin, Franck, MSc, Creveuil, Christian, PhD, Parienti, Jean-Jacques, Prof, Scherpereel, Arnaud, Prof
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Anti-inflammatory agents Antineoplastic Combined Chemotherapy Protocols - therapeutic use Asbestos Bevacizumab - administration & dosage Bevacizumab - adverse effects Central nervous system Chemotherapy Cisplatin - administration & dosage Cisplatin - adverse effects Clinical trials Creatinine - blood Female Histology Humans Hypertension Hypertension - epidemiology Internal Medicine Life expectancy Lung Neoplasms - drug therapy Lung Neoplasms - mortality Lung Neoplasms - pathology Male Medical prognosis Mesothelioma Mesothelioma - drug therapy Mesothelioma - mortality Mesothelioma - pathology Mesothelioma, Malignant Middle Aged Neutropenia Nonsteroidal anti-inflammatory drugs PCB Pemetrexed - administration & dosage Pemetrexed - adverse effects Pleural Neoplasms - drug therapy Pleural Neoplasms - mortality Pleural Neoplasms - pathology Polychlorinated biphenyls Proteinuria - epidemiology Thrombosis - epidemiology Vascular endothelial growth factor Vascular Endothelial Growth Factor A - blood
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