Proteomic and ultrastructural analysis of the effect of a new nitazoxanide- N -methyl-1 H -benzimidazole hybrid against Giardia intestinalis

In an effort to develop alternative drugs for the treatment of giardiasis our research group has synthesized and evaluated a novel nitazoxanide andN-methyl-1H-benzimidazole hybrid molecule, namedCMC-20. It showed an IC50of 0.010μM onGiardia intestinalis, lower than the IC50values of 0.015, 0.037 and...

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Veröffentlicht in:	Research in veterinary science 2016-04, Vol.105, p.171
Hauptverfasser:	Matadamas-Martínez, Félix, Castillo, Rafael, Hernández-Campos, Alicia, Méndez-Cuesta, Carlos, de Souza, Wanderley, Gadelha, Ana Paula, Nogueda-Torres, Benjamín, Hernández, José Manuel, Yépez-Mulia, Lilián
Format:	Artikel
Sprache:	eng
Schlagworte:	Deoxyribonucleic acid DNA Drugs Heat shock proteins Parasites Pathogenesis Spectrum analysis Studies Veterinary medicine
Online-Zugang:	Volltext
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