Dietary Flavonoid Hyperoside Induces Apoptosis of Activated Human LX-2 Hepatic Stellate Cell by Suppressing Canonical NF-[kappa]B Signaling
Hyperoside, an active compound found in plants of the genera Hypericum and Crataegus, is reported to exhibit antioxidant, anticancer, and anti-inflammatory activities. Induction of hepatic stellate cell (HSC) apoptosis is recognized as a promising strategy for attenuation of hepatic fibrosis. In thi...
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| creator | Wang, Liwen Yue, Zhiwei Guo, Mengzheng Fang, Lianying Bai, Liang Li, Xinyu Tao, Yongqing Wang, Suying Liu, Qiang Zhi, Dexian Zhao, Hui |
| description | Hyperoside, an active compound found in plants of the genera Hypericum and Crataegus, is reported to exhibit antioxidant, anticancer, and anti-inflammatory activities. Induction of hepatic stellate cell (HSC) apoptosis is recognized as a promising strategy for attenuation of hepatic fibrosis. In this study, we investigated whether hyperoside treatment can exert antifibrotic effects in human LX-2 hepatic stellate cells. We found that hyperoside induced apoptosis in LX-2 cells and decreased levels of α-smooth muscle actin (α-SMA), type I collagen, and intracellular reactive oxygen species (ROS). Remarkably, hyperoside also inhibited the DNA-binding activity of the transcription factor NF-κB and altered expression levels of NF-κB-regulated genes related to apoptosis, including proapoptotic genes Bcl-Xs, DR4, Fas, and FasL and anti-apoptotic genes A20, c-IAP1, Bcl-[subscript]XL[/subscript] , and RIP1. Our results suggest that hyperoside may have potential as a therapeutic agent for the treatment of liver fibrosis. |
| doi_str_mv | 10.1155/2016/1068528 |
| format | Article |
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Induction of hepatic stellate cell (HSC) apoptosis is recognized as a promising strategy for attenuation of hepatic fibrosis. In this study, we investigated whether hyperoside treatment can exert antifibrotic effects in human LX-2 hepatic stellate cells. We found that hyperoside induced apoptosis in LX-2 cells and decreased levels of α-smooth muscle actin (α-SMA), type I collagen, and intracellular reactive oxygen species (ROS). Remarkably, hyperoside also inhibited the DNA-binding activity of the transcription factor NF-κB and altered expression levels of NF-κB-regulated genes related to apoptosis, including proapoptotic genes Bcl-Xs, DR4, Fas, and FasL and anti-apoptotic genes A20, c-IAP1, Bcl-[subscript]XL[/subscript] , and RIP1. Our results suggest that hyperoside may have potential as a therapeutic agent for the treatment of liver fibrosis.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2016/1068528</identifier><language>eng</language><publisher>New York: John Wiley & Sons, Inc</publisher><subject>Apoptosis ; Bioflavonoids ; Care and treatment ; Cellular signal transduction ; Chinese medicine ; Fibrosis ; Flavones ; Flavonoids ; Genetic aspects ; Health aspects ; Hepatitis ; Laboratories ; Liver cancer ; Liver cirrhosis ; Liver diseases ; Mortality ; Proteins ; Rodents ; Science ; Studies ; Transcription factors</subject><ispartof>BioMed research international, 2016-01, Vol.2016</ispartof><rights>COPYRIGHT 2016 John Wiley & Sons, Inc.</rights><rights>Copyright © 2016 Liwen Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids></links><search><creatorcontrib>Wang, Liwen</creatorcontrib><creatorcontrib>Yue, Zhiwei</creatorcontrib><creatorcontrib>Guo, Mengzheng</creatorcontrib><creatorcontrib>Fang, Lianying</creatorcontrib><creatorcontrib>Bai, Liang</creatorcontrib><creatorcontrib>Li, Xinyu</creatorcontrib><creatorcontrib>Tao, Yongqing</creatorcontrib><creatorcontrib>Wang, Suying</creatorcontrib><creatorcontrib>Liu, Qiang</creatorcontrib><creatorcontrib>Zhi, Dexian</creatorcontrib><creatorcontrib>Zhao, Hui</creatorcontrib><title>Dietary Flavonoid Hyperoside Induces Apoptosis of Activated Human LX-2 Hepatic Stellate Cell by Suppressing Canonical NF-[kappa]B Signaling</title><title>BioMed research international</title><description>Hyperoside, an active compound found in plants of the genera Hypericum and Crataegus, is reported to exhibit antioxidant, anticancer, and anti-inflammatory activities. Induction of hepatic stellate cell (HSC) apoptosis is recognized as a promising strategy for attenuation of hepatic fibrosis. In this study, we investigated whether hyperoside treatment can exert antifibrotic effects in human LX-2 hepatic stellate cells. We found that hyperoside induced apoptosis in LX-2 cells and decreased levels of α-smooth muscle actin (α-SMA), type I collagen, and intracellular reactive oxygen species (ROS). Remarkably, hyperoside also inhibited the DNA-binding activity of the transcription factor NF-κB and altered expression levels of NF-κB-regulated genes related to apoptosis, including proapoptotic genes Bcl-Xs, DR4, Fas, and FasL and anti-apoptotic genes A20, c-IAP1, Bcl-[subscript]XL[/subscript] , and RIP1. Our results suggest that hyperoside may have potential as a therapeutic agent for the treatment of liver fibrosis.</description><subject>Apoptosis</subject><subject>Bioflavonoids</subject><subject>Care and treatment</subject><subject>Cellular signal transduction</subject><subject>Chinese medicine</subject><subject>Fibrosis</subject><subject>Flavones</subject><subject>Flavonoids</subject><subject>Genetic aspects</subject><subject>Health aspects</subject><subject>Hepatitis</subject><subject>Laboratories</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>Mortality</subject><subject>Proteins</subject><subject>Rodents</subject><subject>Science</subject><subject>Studies</subject><subject>Transcription 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Flavonoid Hyperoside Induces Apoptosis of Activated Human LX-2 Hepatic Stellate Cell by Suppressing Canonical NF-[kappa]B Signaling</title><author>Wang, Liwen ; Yue, Zhiwei ; Guo, Mengzheng ; Fang, Lianying ; Bai, Liang ; Li, Xinyu ; Tao, Yongqing ; Wang, Suying ; Liu, Qiang ; Zhi, Dexian ; Zhao, Hui</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-g126t-d5c36a2109e75c5a274d7b0f6de6516339225d6982b96501ccf8f6eb838878923</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Apoptosis</topic><topic>Bioflavonoids</topic><topic>Care and treatment</topic><topic>Cellular signal transduction</topic><topic>Chinese medicine</topic><topic>Fibrosis</topic><topic>Flavones</topic><topic>Flavonoids</topic><topic>Genetic aspects</topic><topic>Health aspects</topic><topic>Hepatitis</topic><topic>Laboratories</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver 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anti-inflammatory activities. Induction of hepatic stellate cell (HSC) apoptosis is recognized as a promising strategy for attenuation of hepatic fibrosis. In this study, we investigated whether hyperoside treatment can exert antifibrotic effects in human LX-2 hepatic stellate cells. We found that hyperoside induced apoptosis in LX-2 cells and decreased levels of α-smooth muscle actin (α-SMA), type I collagen, and intracellular reactive oxygen species (ROS). Remarkably, hyperoside also inhibited the DNA-binding activity of the transcription factor NF-κB and altered expression levels of NF-κB-regulated genes related to apoptosis, including proapoptotic genes Bcl-Xs, DR4, Fas, and FasL and anti-apoptotic genes A20, c-IAP1, Bcl-[subscript]XL[/subscript] , and RIP1. Our results suggest that hyperoside may have potential as a therapeutic agent for the treatment of liver fibrosis.</abstract><cop>New York</cop><pub>John Wiley & Sons, Inc</pub><doi>10.1155/2016/1068528</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Apoptosis Bioflavonoids Care and treatment Cellular signal transduction Chinese medicine Fibrosis Flavones Flavonoids Genetic aspects Health aspects Hepatitis Laboratories Liver cancer Liver cirrhosis Liver diseases Mortality Proteins Rodents Science Studies Transcription factors |
| title | Dietary Flavonoid Hyperoside Induces Apoptosis of Activated Human LX-2 Hepatic Stellate Cell by Suppressing Canonical NF-[kappa]B Signaling |
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