Activation of [beta]-catenin signalling by TFF1 loss promotes cell proliferation and gastric tumorigenesis

Objective In this study, we investigated the role of Trefoil factor 1 (TFF1) in regulating cell proliferation and tumour development through β-catenin signalling using in vivo and in vitro models of gastric tumorigenesis. Design Tff1 -knockout (Tff1 -KO) mice, immunohistochemistry, luciferase report...

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Veröffentlicht in:	Gut 2015-07, Vol.64 (7), p.1028
Hauptverfasser:	Soutto, Mohammed, Peng, DunFa, Katsha, Ahmed, Chen, Zheng, Piazuelo, Maria Blanca, Washington, Mary Kay, Belkhiri, Abbes, Correa, Pelayo, El-Rifai, Wael
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell growth Colorectal cancer Gastric cancer Gene expression Kinases Phosphatase Phosphorylation Proteins Rodents Tumorigenesis
Online-Zugang:	Volltext
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