Intrauterine exposure and pharmacology of conventional thiopurine therapy in pregnant patients with inflammatory bowel disease

Objective Several studies have demonstrated a favourable safety profile for thiopurine use for inflammatory bowel disease (IBD) during pregnancy. We performed a study in pregnant patients with IBD who were using thiopurines, in order to determine the influence of pregnancy on thiopurine metabolism a...

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Veröffentlicht in:	Gut 2014-03, Vol.63 (3), p.451-457
Hauptverfasser:	Jharap, Bindia, de Boer, Nanne K H, Stokkers, Pieter, Hommes, Daniel W, Oldenburg, Bas, Dijkstra, Gerard, van der Woude, C Janneke, de Jong, Dirk J, Mulder, Chris J J, van Elburg, Ruurd M, van Bodegraven, Adriaan A
Format:	Artikel
Sprache:	eng
Schlagworte:	Abnormalities, Drug-Induced - etiology Abortion Adolescent Adult Anemia, Neonatal - chemically induced Azathioprine - adverse effects Azathioprine - pharmacokinetics Azathioprine - therapeutic use Biomarkers - blood Female Fetal Blood - chemistry Fetuses Follow-Up Studies Guanine Nucleotides - blood Humans Immunosuppressive Agents - adverse effects Immunosuppressive Agents - pharmacokinetics Immunosuppressive Agents - therapeutic use Infant, Newborn Inflammatory bowel disease Inflammatory Bowel Diseases - blood Inflammatory Bowel Diseases - drug therapy Mercaptopurine - adverse effects Mercaptopurine - analogs & derivatives Mercaptopurine - blood Mercaptopurine - pharmacokinetics Mercaptopurine - therapeutic use Metabolism Metabolites Middle Aged Miscarriage Mothers Pharmacy Preeclampsia Pregnancy Pregnancy Complications - blood Pregnancy Complications - drug therapy Pregnancy Outcome Prospective Studies Studies Thionucleotides - blood Treatment Outcome Young Adult
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