PWE-001 Ambulant high resolution manometry studies of the mechanisms of gastro-oesophageal reflux in patients with and without evidence of hiatus hernia
IntroductionRecent studies have shown that high resolution manometry (HRM) detects more transient lower oesophageal relaxation (tLOSR) than the established sleeve sensor. Previous studies using the sleeve sensor have suggested that when a hiatus hernia (HH) is present and in patients with more sever...
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| Veröffentlicht in: | Gut 2012-07, Vol.61 (Suppl 2), p.A297-A297 |
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| description | IntroductionRecent studies have shown that high resolution manometry (HRM) detects more transient lower oesophageal relaxation (tLOSR) than the established sleeve sensor. Previous studies using the sleeve sensor have suggested that when a hiatus hernia (HH) is present and in patients with more severe oesophagitis, gastro-oesophageal reflux (GOR) more commonly occurs due to mechanisms other than TLOSR. We have developed a unique ambulatory HRM system to study mechanisms of GORD under more physiological conditions in patients with reflux oesophagitis or Barrett's oesophagus, with and without hiatus hernia.Methods10 patients with HH and six patients without HH (all with an endoscopic diagnosis of reflux oesophagitis) were studied after a fast for at least 4 h. A 36 channel solid state HRM/impedance catheter was placed spanning the stomach to pharynx. A pH electrode was placed 5 cm above the GOJ. Patients were studied at rest and during 15 min of standardised exercise on an exercise bike, before and after a meal (sausage or bacon with egg sandwich with 500 mls of milkshake—736 calories). In addition subjects walked for 30 min in the post-prandial period.Results12 patients were male; median age 60 (range 35–76) years; six patients had LA A/B oesophagitis and 10 patients had LA C/D (5) or Barrett's oesophagus (5). Acid reflux episodes in patients with HH were due to tLOSR in 90%, low LOS pressure in 6% and swallowing in 4%, whereas in patients without HH they were due to tLOSR in 88%, low LOS pressure in 4% and swallowing in 8%. tLOSR appeared to be more frequent in patients with HH (13.5 (IQR 11.1–18.7) per hour vs 10 (IQR 7.6–15.6) per hour) but this difference fell short of statistical significance (p=0.06). There was no difference in the proportion of TLOSR associated with acid reflux in patients with (59%) and without HH (47%) but patients with HH were more likely to have impedance evidence of gas or liquid reflux during tLOSR than patients without HH (96% vs 83%, p |
| doi_str_mv | 10.1136/gutjnl-2012-302514d.1 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1779435339</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4014630271</sourcerecordid><originalsourceid>FETCH-LOGICAL-b2001-3165d54e3f67f0b219e928e88a11d3e0b9934fe5945569fb05fabf3f49a273ad3</originalsourceid><addsrcrecordid>eNqNUc1u1DAQjhBILC2PgGSJs4sdx4l9rFYtBVVQVRQkLpazGW-8JPbiH2hvXHgJHo8nwdtUnHua0cz3M6Ovql5RckIpa99sc9q5CdeE1piRmtNmOKFPqhVtWoFZLcTTakUI7TDvGvm8ehHjjhAihKSr6s_VlzNcln9__T6d-zxpl9BotyMKEP2Uk_UOzdr5GVK4QzHlwUJE3qA0ApphM2pn43w_2eqYgse-EPej3oKeioiZ8i2yDu11suBSRD9tGpF2w33jc0Lwww7gNnCQGK1OOaIRgrP6uHpm9BTh5UM9qm7Ozz6tL_Dlx7fv1qeXuK_L4ZjRlg-8AWbazpC-phJkLUAITenAgPRSssYAlw3nrTQ94Ub3hplG6rpjemBH1etFdx_89wwxqZ3PwRVLRbtONowzJguKL6hN8DGWx9Q-2FmHO0WJOsSglhjUIQb1EIOihYcXno0Jbv-TdPim2o51XH34vFbvz6_EBfvK1HXBkwXfz7tHWvwDfvSfRw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1779435339</pqid></control><display><type>article</type><title>PWE-001 Ambulant high resolution manometry studies of the mechanisms of gastro-oesophageal reflux in patients with and without evidence of hiatus hernia</title><source>BMJ Journals - NESLi2</source><source>PubMed Central</source><creator>Theron, B T ; Yamamoto, A ; Aladin, H ; Trudgill, N</creator><creatorcontrib>Theron, B T ; Yamamoto, A ; Aladin, H ; Trudgill, N</creatorcontrib><description>IntroductionRecent studies have shown that high resolution manometry (HRM) detects more transient lower oesophageal relaxation (tLOSR) than the established sleeve sensor. Previous studies using the sleeve sensor have suggested that when a hiatus hernia (HH) is present and in patients with more severe oesophagitis, gastro-oesophageal reflux (GOR) more commonly occurs due to mechanisms other than TLOSR. We have developed a unique ambulatory HRM system to study mechanisms of GORD under more physiological conditions in patients with reflux oesophagitis or Barrett's oesophagus, with and without hiatus hernia.Methods10 patients with HH and six patients without HH (all with an endoscopic diagnosis of reflux oesophagitis) were studied after a fast for at least 4 h. A 36 channel solid state HRM/impedance catheter was placed spanning the stomach to pharynx. A pH electrode was placed 5 cm above the GOJ. Patients were studied at rest and during 15 min of standardised exercise on an exercise bike, before and after a meal (sausage or bacon with egg sandwich with 500 mls of milkshake—736 calories). In addition subjects walked for 30 min in the post-prandial period.Results12 patients were male; median age 60 (range 35–76) years; six patients had LA A/B oesophagitis and 10 patients had LA C/D (5) or Barrett's oesophagus (5). Acid reflux episodes in patients with HH were due to tLOSR in 90%, low LOS pressure in 6% and swallowing in 4%, whereas in patients without HH they were due to tLOSR in 88%, low LOS pressure in 4% and swallowing in 8%. tLOSR appeared to be more frequent in patients with HH (13.5 (IQR 11.1–18.7) per hour vs 10 (IQR 7.6–15.6) per hour) but this difference fell short of statistical significance (p=0.06). There was no difference in the proportion of TLOSR associated with acid reflux in patients with (59%) and without HH (47%) but patients with HH were more likely to have impedance evidence of gas or liquid reflux during tLOSR than patients without HH (96% vs 83%, p<0.001).ConclusionProlonged ambulant studies of the mechanisms associated with acid gastro-oesophageal reflux reveal that tLOSRs are the predominant mechanism associated with acid reflux in patients with oesophagitis or Barrett's oesophagus both with and without HH. tLOSR appeared to be more common in patients with HH but this difference fell short of statistical significance. Patients with HH were more likely to have evidence of reflux during tLOSR.Competing interestsNone declared.</description><identifier>ISSN: 0017-5749</identifier><identifier>EISSN: 1468-3288</identifier><identifier>DOI: 10.1136/gutjnl-2012-302514d.1</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and British Society of Gastroenterology</publisher><subject>Acids ; Bacon ; Barrett's esophagus ; Calories ; Esophagitis ; Gastroesophageal reflux ; Hernia ; Hernias ; Pharynx ; Pressure ; Statistics ; Stomach ; Swallowing</subject><ispartof>Gut, 2012-07, Vol.61 (Suppl 2), p.A297-A297</ispartof><rights>2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright: 2012 © 2012, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://gut.bmj.com/content/61/Suppl_2/A297.1.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://gut.bmj.com/content/61/Suppl_2/A297.1.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,780,784,3196,23571,27924,27925,77600,77631</link.rule.ids></links><search><creatorcontrib>Theron, B T</creatorcontrib><creatorcontrib>Yamamoto, A</creatorcontrib><creatorcontrib>Aladin, H</creatorcontrib><creatorcontrib>Trudgill, N</creatorcontrib><title>PWE-001 Ambulant high resolution manometry studies of the mechanisms of gastro-oesophageal reflux in patients with and without evidence of hiatus hernia</title><title>Gut</title><addtitle>Gut</addtitle><description>IntroductionRecent studies have shown that high resolution manometry (HRM) detects more transient lower oesophageal relaxation (tLOSR) than the established sleeve sensor. Previous studies using the sleeve sensor have suggested that when a hiatus hernia (HH) is present and in patients with more severe oesophagitis, gastro-oesophageal reflux (GOR) more commonly occurs due to mechanisms other than TLOSR. We have developed a unique ambulatory HRM system to study mechanisms of GORD under more physiological conditions in patients with reflux oesophagitis or Barrett's oesophagus, with and without hiatus hernia.Methods10 patients with HH and six patients without HH (all with an endoscopic diagnosis of reflux oesophagitis) were studied after a fast for at least 4 h. A 36 channel solid state HRM/impedance catheter was placed spanning the stomach to pharynx. A pH electrode was placed 5 cm above the GOJ. Patients were studied at rest and during 15 min of standardised exercise on an exercise bike, before and after a meal (sausage or bacon with egg sandwich with 500 mls of milkshake—736 calories). In addition subjects walked for 30 min in the post-prandial period.Results12 patients were male; median age 60 (range 35–76) years; six patients had LA A/B oesophagitis and 10 patients had LA C/D (5) or Barrett's oesophagus (5). Acid reflux episodes in patients with HH were due to tLOSR in 90%, low LOS pressure in 6% and swallowing in 4%, whereas in patients without HH they were due to tLOSR in 88%, low LOS pressure in 4% and swallowing in 8%. tLOSR appeared to be more frequent in patients with HH (13.5 (IQR 11.1–18.7) per hour vs 10 (IQR 7.6–15.6) per hour) but this difference fell short of statistical significance (p=0.06). There was no difference in the proportion of TLOSR associated with acid reflux in patients with (59%) and without HH (47%) but patients with HH were more likely to have impedance evidence of gas or liquid reflux during tLOSR than patients without HH (96% vs 83%, p<0.001).ConclusionProlonged ambulant studies of the mechanisms associated with acid gastro-oesophageal reflux reveal that tLOSRs are the predominant mechanism associated with acid reflux in patients with oesophagitis or Barrett's oesophagus both with and without HH. tLOSR appeared to be more common in patients with HH but this difference fell short of statistical significance. Patients with HH were more likely to have evidence of reflux during tLOSR.Competing interestsNone declared.</description><subject>Acids</subject><subject>Bacon</subject><subject>Barrett's esophagus</subject><subject>Calories</subject><subject>Esophagitis</subject><subject>Gastroesophageal reflux</subject><subject>Hernia</subject><subject>Hernias</subject><subject>Pharynx</subject><subject>Pressure</subject><subject>Statistics</subject><subject>Stomach</subject><subject>Swallowing</subject><issn>0017-5749</issn><issn>1468-3288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNUc1u1DAQjhBILC2PgGSJs4sdx4l9rFYtBVVQVRQkLpazGW-8JPbiH2hvXHgJHo8nwdtUnHua0cz3M6Ovql5RckIpa99sc9q5CdeE1piRmtNmOKFPqhVtWoFZLcTTakUI7TDvGvm8ehHjjhAihKSr6s_VlzNcln9__T6d-zxpl9BotyMKEP2Uk_UOzdr5GVK4QzHlwUJE3qA0ApphM2pn43w_2eqYgse-EPej3oKeioiZ8i2yDu11suBSRD9tGpF2w33jc0Lwww7gNnCQGK1OOaIRgrP6uHpm9BTh5UM9qm7Ozz6tL_Dlx7fv1qeXuK_L4ZjRlg-8AWbazpC-phJkLUAITenAgPRSssYAlw3nrTQ94Ub3hplG6rpjemBH1etFdx_89wwxqZ3PwRVLRbtONowzJguKL6hN8DGWx9Q-2FmHO0WJOsSglhjUIQb1EIOihYcXno0Jbv-TdPim2o51XH34vFbvz6_EBfvK1HXBkwXfz7tHWvwDfvSfRw</recordid><startdate>201207</startdate><enddate>201207</enddate><creator>Theron, B T</creator><creator>Yamamoto, A</creator><creator>Aladin, H</creator><creator>Trudgill, N</creator><general>BMJ Publishing Group Ltd and British Society of Gastroenterology</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>201207</creationdate><title>PWE-001 Ambulant high resolution manometry studies of the mechanisms of gastro-oesophageal reflux in patients with and without evidence of hiatus hernia</title><author>Theron, B T ; Yamamoto, A ; Aladin, H ; Trudgill, N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b2001-3165d54e3f67f0b219e928e88a11d3e0b9934fe5945569fb05fabf3f49a273ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Acids</topic><topic>Bacon</topic><topic>Barrett's esophagus</topic><topic>Calories</topic><topic>Esophagitis</topic><topic>Gastroesophageal reflux</topic><topic>Hernia</topic><topic>Hernias</topic><topic>Pharynx</topic><topic>Pressure</topic><topic>Statistics</topic><topic>Stomach</topic><topic>Swallowing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Theron, B T</creatorcontrib><creatorcontrib>Yamamoto, A</creatorcontrib><creatorcontrib>Aladin, H</creatorcontrib><creatorcontrib>Trudgill, N</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Gut</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Theron, B T</au><au>Yamamoto, A</au><au>Aladin, H</au><au>Trudgill, N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PWE-001 Ambulant high resolution manometry studies of the mechanisms of gastro-oesophageal reflux in patients with and without evidence of hiatus hernia</atitle><jtitle>Gut</jtitle><addtitle>Gut</addtitle><date>2012-07</date><risdate>2012</risdate><volume>61</volume><issue>Suppl 2</issue><spage>A297</spage><epage>A297</epage><pages>A297-A297</pages><issn>0017-5749</issn><eissn>1468-3288</eissn><abstract>IntroductionRecent studies have shown that high resolution manometry (HRM) detects more transient lower oesophageal relaxation (tLOSR) than the established sleeve sensor. Previous studies using the sleeve sensor have suggested that when a hiatus hernia (HH) is present and in patients with more severe oesophagitis, gastro-oesophageal reflux (GOR) more commonly occurs due to mechanisms other than TLOSR. We have developed a unique ambulatory HRM system to study mechanisms of GORD under more physiological conditions in patients with reflux oesophagitis or Barrett's oesophagus, with and without hiatus hernia.Methods10 patients with HH and six patients without HH (all with an endoscopic diagnosis of reflux oesophagitis) were studied after a fast for at least 4 h. A 36 channel solid state HRM/impedance catheter was placed spanning the stomach to pharynx. A pH electrode was placed 5 cm above the GOJ. Patients were studied at rest and during 15 min of standardised exercise on an exercise bike, before and after a meal (sausage or bacon with egg sandwich with 500 mls of milkshake—736 calories). In addition subjects walked for 30 min in the post-prandial period.Results12 patients were male; median age 60 (range 35–76) years; six patients had LA A/B oesophagitis and 10 patients had LA C/D (5) or Barrett's oesophagus (5). Acid reflux episodes in patients with HH were due to tLOSR in 90%, low LOS pressure in 6% and swallowing in 4%, whereas in patients without HH they were due to tLOSR in 88%, low LOS pressure in 4% and swallowing in 8%. tLOSR appeared to be more frequent in patients with HH (13.5 (IQR 11.1–18.7) per hour vs 10 (IQR 7.6–15.6) per hour) but this difference fell short of statistical significance (p=0.06). There was no difference in the proportion of TLOSR associated with acid reflux in patients with (59%) and without HH (47%) but patients with HH were more likely to have impedance evidence of gas or liquid reflux during tLOSR than patients without HH (96% vs 83%, p<0.001).ConclusionProlonged ambulant studies of the mechanisms associated with acid gastro-oesophageal reflux reveal that tLOSRs are the predominant mechanism associated with acid reflux in patients with oesophagitis or Barrett's oesophagus both with and without HH. tLOSR appeared to be more common in patients with HH but this difference fell short of statistical significance. Patients with HH were more likely to have evidence of reflux during tLOSR.Competing interestsNone declared.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd and British Society of Gastroenterology</pub><doi>10.1136/gutjnl-2012-302514d.1</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Acids Bacon Barrett's esophagus Calories Esophagitis Gastroesophageal reflux Hernia Hernias Pharynx Pressure Statistics Stomach Swallowing |
| title | PWE-001 Ambulant high resolution manometry studies of the mechanisms of gastro-oesophageal reflux in patients with and without evidence of hiatus hernia |
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