Relatedness and HLA-DRB1 typing may discriminate the magnitude of the genetic susceptibility to tuberculosis using a household contact model

BackgroundTuberculosis clusters in families may be due to increased household exposure, shared genetic factors, or both. Household contact studies are useful to control exposure because socioeconomic and environmental conditions are similar to all subjects, allowing the evaluation of the contributio...

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Veröffentlicht in:	Journal of epidemiology and community health (1979) 2010-06, Vol.64 (6), p.513-517
Hauptverfasser:	Lucena-Silva, N, Baliza, M D, Martins, A E S, Deghaide, N H S, Teixeira, K M, Rodrigues, L C, Ximenes, R, Donadi, E A, de Albuquerque, M d F P M
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Bacterial diseases Biological and medical sciences Couples Crowding Environmental conditions Epidemiology Families & family life Gene Frequency General aspects Genetic factors Genetic Predisposition to Disease Health facilities Health risk assessment HLA antigens HLA-DRB1 Chains household contact Households Housing Human bacterial diseases Human genetics Humans Infectious diseases Medical genetics Medical sciences Middle Aged Miscellaneous Mycobacterium tuberculosis pedigree analysis Population Population levels Public health. Hygiene Public health. Hygiene-occupational medicine Pulmonary tuberculosis Research reports Risk factors risk of tuberculosis Rooms Socioeconomic Factors Studies transmission Tuberculosis Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - genetics Tuberculosis, Pulmonary - transmission Young Adult
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