Relatedness and HLA-DRB1 typing may discriminate the magnitude of the genetic susceptibility to tuberculosis using a household contact model
BackgroundTuberculosis clusters in families may be due to increased household exposure, shared genetic factors, or both. Household contact studies are useful to control exposure because socioeconomic and environmental conditions are similar to all subjects, allowing the evaluation of the contributio...
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| Veröffentlicht in: | Journal of epidemiology and community health (1979) 2010-06, Vol.64 (6), p.513-517 |
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| container_title | Journal of epidemiology and community health (1979) |
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| creator | Lucena-Silva, N Baliza, M D Martins, A E S Deghaide, N H S Teixeira, K M Rodrigues, L C Ximenes, R Donadi, E A de Albuquerque, M d F P M |
| description | BackgroundTuberculosis clusters in families may be due to increased household exposure, shared genetic factors, or both. Household contact studies are useful to control exposure because socioeconomic and environmental conditions are similar to all subjects, allowing the evaluation of the contribution of relatedness to disease development.MethodsIn this study, the familial aggregation of tuberculosis using relatedness and a specific inherited marker (HLA-DRB1) was evaluated. Fifty families, which had at least two cases of tuberculosis diagnosed within the past 5 years, were selected from a cohort of tuberculosis carried out in Recife, Brazil. The first case diagnosed was considered to be a primary case. The secondary attack rate of tuberculosis in household contacts was estimated according to the degree of relatedness. The relative risk of having tuberculosis based on the degree of relatedness household and the population attributable fraction to relatedness were also estimated. HLA-DRB1 typing and attributable etiologic/preventive fractions were calculated among sick and healthy household contacts.ResultsCompared to unrelated contacts, the relative risk for tuberculosis adjusted for age was 1.38 (95% CI 0.86 to 2.21). Relatedness contributed 23% to the development of tuberculosis at the population levels. The HLA-DRB1*04 allele group (OR=2.44; p=0.0324; etiologic fraction=0.15) was overrepresented and the DRB1*15 allele group (OR=0.48; p=0.0488; protective fraction=0.19) was underrepresented among household contacts exhibiting tuberculosis. The presence of DRB1 shared alleles between primary cases and their contacts was a risk factor for tuberculosis (p=0.0281).ConclusionThis household contact model together with the utilisation of two genetic variables permitted the evaluation of genetic factors contributing towards tuberculosis development. |
| doi_str_mv | 10.1136/jech.2008.086801 |
| format | Article |
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Household contact studies are useful to control exposure because socioeconomic and environmental conditions are similar to all subjects, allowing the evaluation of the contribution of relatedness to disease development.MethodsIn this study, the familial aggregation of tuberculosis using relatedness and a specific inherited marker (HLA-DRB1) was evaluated. Fifty families, which had at least two cases of tuberculosis diagnosed within the past 5 years, were selected from a cohort of tuberculosis carried out in Recife, Brazil. The first case diagnosed was considered to be a primary case. The secondary attack rate of tuberculosis in household contacts was estimated according to the degree of relatedness. The relative risk of having tuberculosis based on the degree of relatedness household and the population attributable fraction to relatedness were also estimated. HLA-DRB1 typing and attributable etiologic/preventive fractions were calculated among sick and healthy household contacts.ResultsCompared to unrelated contacts, the relative risk for tuberculosis adjusted for age was 1.38 (95% CI 0.86 to 2.21). Relatedness contributed 23% to the development of tuberculosis at the population levels. The HLA-DRB1*04 allele group (OR=2.44; p=0.0324; etiologic fraction=0.15) was overrepresented and the DRB1*15 allele group (OR=0.48; p=0.0488; protective fraction=0.19) was underrepresented among household contacts exhibiting tuberculosis. The presence of DRB1 shared alleles between primary cases and their contacts was a risk factor for tuberculosis (p=0.0281).ConclusionThis household contact model together with the utilisation of two genetic variables permitted the evaluation of genetic factors contributing towards tuberculosis development.</description><identifier>ISSN: 0143-005X</identifier><identifier>EISSN: 1470-2738</identifier><identifier>DOI: 10.1136/jech.2008.086801</identifier><identifier>PMID: 19692729</identifier><identifier>CODEN: JECHDR</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd</publisher><subject>Adolescent ; Adult ; Bacterial diseases ; Biological and medical sciences ; Couples ; Crowding ; Environmental conditions ; Epidemiology ; Families & family life ; Gene Frequency ; General aspects ; Genetic factors ; Genetic Predisposition to Disease ; Health facilities ; Health risk assessment ; HLA antigens ; HLA-DRB1 Chains ; household contact ; Households ; Housing ; Human bacterial diseases ; Human genetics ; Humans ; Infectious diseases ; Medical genetics ; Medical sciences ; Middle Aged ; Miscellaneous ; Mycobacterium tuberculosis ; pedigree analysis ; Population ; Population levels ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Pulmonary tuberculosis ; Research reports ; Risk factors ; risk of tuberculosis ; Rooms ; Socioeconomic Factors ; Studies ; transmission ; Tuberculosis ; Tuberculosis and atypical mycobacterial infections ; Tuberculosis, Pulmonary - genetics ; Tuberculosis, Pulmonary - transmission ; Young Adult</subject><ispartof>Journal of epidemiology and community health (1979), 2010-06, Vol.64 (6), p.513-517</ispartof><rights>2010, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><rights>Copyright © 2010 BMJ Publishing Group</rights><rights>2015 INIST-CNRS</rights><rights>Copyright: 2010 (c) 2010, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b420t-fc34ffc2caa8b9e97eda93fc975135590333a2b59d53facd99c2081731fa81463</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://jech.bmj.com/content/64/6/513.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttps://jech.bmj.com/content/64/6/513.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,799,3183,23550,27901,27902,57992,58225,77342,77373</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22788832$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19692729$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lucena-Silva, N</creatorcontrib><creatorcontrib>Baliza, M D</creatorcontrib><creatorcontrib>Martins, A E S</creatorcontrib><creatorcontrib>Deghaide, N H S</creatorcontrib><creatorcontrib>Teixeira, K M</creatorcontrib><creatorcontrib>Rodrigues, L C</creatorcontrib><creatorcontrib>Ximenes, R</creatorcontrib><creatorcontrib>Donadi, E A</creatorcontrib><creatorcontrib>de Albuquerque, M d F P M</creatorcontrib><title>Relatedness and HLA-DRB1 typing may discriminate the magnitude of the genetic susceptibility to tuberculosis using a household contact model</title><title>Journal of epidemiology and community health (1979)</title><addtitle>J Epidemiol Community Health</addtitle><description>BackgroundTuberculosis clusters in families may be due to increased household exposure, shared genetic factors, or both. Household contact studies are useful to control exposure because socioeconomic and environmental conditions are similar to all subjects, allowing the evaluation of the contribution of relatedness to disease development.MethodsIn this study, the familial aggregation of tuberculosis using relatedness and a specific inherited marker (HLA-DRB1) was evaluated. Fifty families, which had at least two cases of tuberculosis diagnosed within the past 5 years, were selected from a cohort of tuberculosis carried out in Recife, Brazil. The first case diagnosed was considered to be a primary case. The secondary attack rate of tuberculosis in household contacts was estimated according to the degree of relatedness. The relative risk of having tuberculosis based on the degree of relatedness household and the population attributable fraction to relatedness were also estimated. HLA-DRB1 typing and attributable etiologic/preventive fractions were calculated among sick and healthy household contacts.ResultsCompared to unrelated contacts, the relative risk for tuberculosis adjusted for age was 1.38 (95% CI 0.86 to 2.21). Relatedness contributed 23% to the development of tuberculosis at the population levels. The HLA-DRB1*04 allele group (OR=2.44; p=0.0324; etiologic fraction=0.15) was overrepresented and the DRB1*15 allele group (OR=0.48; p=0.0488; protective fraction=0.19) was underrepresented among household contacts exhibiting tuberculosis. The presence of DRB1 shared alleles between primary cases and their contacts was a risk factor for tuberculosis (p=0.0281).ConclusionThis household contact model together with the utilisation of two genetic variables permitted the evaluation of genetic factors contributing towards tuberculosis development.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Couples</subject><subject>Crowding</subject><subject>Environmental conditions</subject><subject>Epidemiology</subject><subject>Families & family life</subject><subject>Gene Frequency</subject><subject>General aspects</subject><subject>Genetic factors</subject><subject>Genetic Predisposition to Disease</subject><subject>Health facilities</subject><subject>Health risk assessment</subject><subject>HLA antigens</subject><subject>HLA-DRB1 Chains</subject><subject>household contact</subject><subject>Households</subject><subject>Housing</subject><subject>Human bacterial diseases</subject><subject>Human genetics</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>Mycobacterium tuberculosis</subject><subject>pedigree analysis</subject><subject>Population</subject><subject>Population levels</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Pulmonary tuberculosis</subject><subject>Research reports</subject><subject>Risk factors</subject><subject>risk of tuberculosis</subject><subject>Rooms</subject><subject>Socioeconomic Factors</subject><subject>Studies</subject><subject>transmission</subject><subject>Tuberculosis</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><subject>Tuberculosis, Pulmonary - genetics</subject><subject>Tuberculosis, Pulmonary - transmission</subject><subject>Young Adult</subject><issn>0143-005X</issn><issn>1470-2738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkE2P0zAQhi0EYruFOxeQJcQJpfgjiePjtiwsqFpgBQhxsRx_tO4mcbEdif4HfjQuqXaPnDya95kZ-QHgGUYLjGn9ZmfUdkEQahaoqRuEH4AZLhkqCKPNQzBDuKQFQtWPM3Ae4w7lkhH-GJxhXnOSyxn4c2M6mYweTIxQDhperS-KtzdLDNNh74YN7OUBahdVcL0bMgnT1uTmZnBp1AZ6-6-xMYNJTsE4RmX2ybWuc-kAk4dpbE1QY-eji3CMx5USbv0YzdZ3Gio_JKkS7L023RPwyMoumqendw6-vbv8uroq1p_ef1hdrIu2JCgVVtHSWkWUlE3LDWdGS06t4qzCtKo4opRK0lZcV9RKpTlXBDWYUWxlg8uazsHLae8--F-jiUns_BiGfFJgxjipOcsG5wBNlAo-xmCs2GcJMhwERuKoXxz1i6N-MenPIy9Oi8e2N_p-4OQ7A69OgIxKdjbIQbl4xxHCmqahJHPPJ24Xkw_3OWIEkxLlvJhyF5P5fZfLcCtqRlklrr-vBFp-uf74ufwplpl_PfFtv_v_N_4CJUG2HA</recordid><startdate>20100601</startdate><enddate>20100601</enddate><creator>Lucena-Silva, N</creator><creator>Baliza, M D</creator><creator>Martins, A E S</creator><creator>Deghaide, N H S</creator><creator>Teixeira, K M</creator><creator>Rodrigues, L C</creator><creator>Ximenes, R</creator><creator>Donadi, E A</creator><creator>de Albuquerque, M d F P M</creator><general>BMJ Publishing Group Ltd</general><general>BMJ Publishing Group</general><general>BMJ Publishing Group LTD</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88I</scope><scope>8AF</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20100601</creationdate><title>Relatedness and HLA-DRB1 typing may discriminate the magnitude of the genetic susceptibility to tuberculosis using a household contact model</title><author>Lucena-Silva, N ; Baliza, M D ; Martins, A E S ; Deghaide, N H S ; Teixeira, K M ; Rodrigues, L C ; Ximenes, R ; Donadi, E A ; de Albuquerque, M d F P M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b420t-fc34ffc2caa8b9e97eda93fc975135590333a2b59d53facd99c2081731fa81463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Couples</topic><topic>Crowding</topic><topic>Environmental conditions</topic><topic>Epidemiology</topic><topic>Families & family life</topic><topic>Gene Frequency</topic><topic>General aspects</topic><topic>Genetic factors</topic><topic>Genetic Predisposition to Disease</topic><topic>Health facilities</topic><topic>Health risk assessment</topic><topic>HLA antigens</topic><topic>HLA-DRB1 Chains</topic><topic>household contact</topic><topic>Households</topic><topic>Housing</topic><topic>Human bacterial diseases</topic><topic>Human genetics</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>Mycobacterium tuberculosis</topic><topic>pedigree analysis</topic><topic>Population</topic><topic>Population levels</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Pulmonary tuberculosis</topic><topic>Research reports</topic><topic>Risk factors</topic><topic>risk of tuberculosis</topic><topic>Rooms</topic><topic>Socioeconomic Factors</topic><topic>Studies</topic><topic>transmission</topic><topic>Tuberculosis</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><topic>Tuberculosis, Pulmonary - genetics</topic><topic>Tuberculosis, Pulmonary - transmission</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lucena-Silva, N</creatorcontrib><creatorcontrib>Baliza, M D</creatorcontrib><creatorcontrib>Martins, A E S</creatorcontrib><creatorcontrib>Deghaide, N H S</creatorcontrib><creatorcontrib>Teixeira, K M</creatorcontrib><creatorcontrib>Rodrigues, L C</creatorcontrib><creatorcontrib>Ximenes, R</creatorcontrib><creatorcontrib>Donadi, E A</creatorcontrib><creatorcontrib>de Albuquerque, M d F P M</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Journal of epidemiology and community health (1979)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lucena-Silva, N</au><au>Baliza, M D</au><au>Martins, A E S</au><au>Deghaide, N H S</au><au>Teixeira, K M</au><au>Rodrigues, L C</au><au>Ximenes, R</au><au>Donadi, E A</au><au>de Albuquerque, M d F P M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relatedness and HLA-DRB1 typing may discriminate the magnitude of the genetic susceptibility to tuberculosis using a household contact model</atitle><jtitle>Journal of epidemiology and community health (1979)</jtitle><addtitle>J Epidemiol Community Health</addtitle><date>2010-06-01</date><risdate>2010</risdate><volume>64</volume><issue>6</issue><spage>513</spage><epage>517</epage><pages>513-517</pages><issn>0143-005X</issn><eissn>1470-2738</eissn><coden>JECHDR</coden><abstract>BackgroundTuberculosis clusters in families may be due to increased household exposure, shared genetic factors, or both. Household contact studies are useful to control exposure because socioeconomic and environmental conditions are similar to all subjects, allowing the evaluation of the contribution of relatedness to disease development.MethodsIn this study, the familial aggregation of tuberculosis using relatedness and a specific inherited marker (HLA-DRB1) was evaluated. Fifty families, which had at least two cases of tuberculosis diagnosed within the past 5 years, were selected from a cohort of tuberculosis carried out in Recife, Brazil. The first case diagnosed was considered to be a primary case. The secondary attack rate of tuberculosis in household contacts was estimated according to the degree of relatedness. The relative risk of having tuberculosis based on the degree of relatedness household and the population attributable fraction to relatedness were also estimated. HLA-DRB1 typing and attributable etiologic/preventive fractions were calculated among sick and healthy household contacts.ResultsCompared to unrelated contacts, the relative risk for tuberculosis adjusted for age was 1.38 (95% CI 0.86 to 2.21). Relatedness contributed 23% to the development of tuberculosis at the population levels. The HLA-DRB1*04 allele group (OR=2.44; p=0.0324; etiologic fraction=0.15) was overrepresented and the DRB1*15 allele group (OR=0.48; p=0.0488; protective fraction=0.19) was underrepresented among household contacts exhibiting tuberculosis. The presence of DRB1 shared alleles between primary cases and their contacts was a risk factor for tuberculosis (p=0.0281).ConclusionThis household contact model together with the utilisation of two genetic variables permitted the evaluation of genetic factors contributing towards tuberculosis development.</abstract><cop>London</cop><pub>BMJ Publishing Group Ltd</pub><pmid>19692729</pmid><doi>10.1136/jech.2008.086801</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of epidemiology and community health (1979), 2010-06, Vol.64 (6), p.513-517 |
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| subjects | Adolescent Adult Bacterial diseases Biological and medical sciences Couples Crowding Environmental conditions Epidemiology Families & family life Gene Frequency General aspects Genetic factors Genetic Predisposition to Disease Health facilities Health risk assessment HLA antigens HLA-DRB1 Chains household contact Households Housing Human bacterial diseases Human genetics Humans Infectious diseases Medical genetics Medical sciences Middle Aged Miscellaneous Mycobacterium tuberculosis pedigree analysis Population Population levels Public health. Hygiene Public health. Hygiene-occupational medicine Pulmonary tuberculosis Research reports Risk factors risk of tuberculosis Rooms Socioeconomic Factors Studies transmission Tuberculosis Tuberculosis and atypical mycobacterial infections Tuberculosis, Pulmonary - genetics Tuberculosis, Pulmonary - transmission Young Adult |
| title | Relatedness and HLA-DRB1 typing may discriminate the magnitude of the genetic susceptibility to tuberculosis using a household contact model |
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