Statin induced myopathy
The use of statins has grown to over 100 million prescriptions per year since their introduction for the treatment of hypercholesterolemia in 1987. As a conservative estimate, at least 1.5 million people per year will experience a muscle related adverse event while taking a statin. Here, Sathasivam...
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| Veröffentlicht in: | BMJ 2008-11, Vol.337 (7679), p.1159-1162 |
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| creator | Sathasivam, Sivakumar Lecky, Bryan |
| description | The use of statins has grown to over 100 million prescriptions per year since their introduction for the treatment of hypercholesterolemia in 1987. As a conservative estimate, at least 1.5 million people per year will experience a muscle related adverse event while taking a statin. Here, Sathasivam and Lecky discuss statin induced myopathy and its management in the light of recent epidemiological studies, randomized controlled trials, and guidelines. Moreover, they point out that if a patient presents with features suggesting statin induced myopathy, first line management is to stop statin therapy and observe any effect on symptoms and concentration of creatine kinase. |
| doi_str_mv | 10.1136/bmj.a2286 |
| format | Article |
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As a conservative estimate, at least 1.5 million people per year will experience a muscle related adverse event while taking a statin. Here, Sathasivam and Lecky discuss statin induced myopathy and its management in the light of recent epidemiological studies, randomized controlled trials, and guidelines. 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| source | Applied Social Sciences Index & Abstracts (ASSIA); Jstor Complete Legacy; MEDLINE; BMJ Journals - NESLi2; Alma/SFX Local Collection |
| subjects | Biological and medical sciences Biopsy Cholesterol Cholesterol - metabolism Clinical Review Clinical trials Coenzymes Creatine Creatine Kinase - blood Disease management Drugs Female General aspects Heart Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects Hydroxymethylglutaryl-CoA Reductase Inhibitors - metabolism Induced Lipids Male Medical sciences Muscles Muscular diseases Muscular Diseases - chemically induced Muscular Diseases - metabolism Muscular Diseases - therapy Myocardium Myositis Neuromuscular diseases Rhabdomyolysis Risk Factors Side effects Statins Symptoms |
| title | Statin induced myopathy |
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