THU0274 Ultrasonographic Inflammatory Activity Predicts Relapse in Rheumatoid Arthritis in Remission
Background Remission is the current aim of treatment in rheumatoid arthritis (RA). Remission is ideally the absence of detectable disease and absence of structural and functional worsening over the time. Infra-clinical synovitis, detected by ultrasound, may persist in patients with remission leading...
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| Veröffentlicht in: | Annals of the rheumatic diseases 2014-06, Vol.73 (Suppl 2), p.278 |
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| creator | Ben Abdelghani, K. Miladi, S. Souabni, L. Kassab, S. Chekili, S. Laatar, A. Zakraoui, L. |
| description | Background Remission is the current aim of treatment in rheumatoid arthritis (RA). Remission is ideally the absence of detectable disease and absence of structural and functional worsening over the time. Infra-clinical synovitis, detected by ultrasound, may persist in patients with remission leading to further structural damage. Objectives The aim of this study was to assess the frequency of relapse after clinical remission and the value of US to predict this relapse. Methods A prospective study of 30 patients followed-up for RA in remission was conducted. The remission was defined by a Disease Activity Score 28 joints (DAS28) ≤2,6 for at least 3 months under the same therapy. A B-mode and Power Doppler (PD) US examination was assessed by an experienced rheumatologist blinded to clinical data for 22 joints (wrists, 10 metacarpo-phalangeals, 10 proximal interphalangeals joints). A semi-quantitative scale running from 0 to 3 depending on US activity was attributed for each joint for PD. Patients were clinically controlled 3 to 6 months after performing the US. The variability of DAS28 was noted, it was considered significant if the p value |
| doi_str_mv | 10.1136/annrheumdis-2014-eular.5242 |
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Remission is ideally the absence of detectable disease and absence of structural and functional worsening over the time. Infra-clinical synovitis, detected by ultrasound, may persist in patients with remission leading to further structural damage. Objectives The aim of this study was to assess the frequency of relapse after clinical remission and the value of US to predict this relapse. Methods A prospective study of 30 patients followed-up for RA in remission was conducted. The remission was defined by a Disease Activity Score 28 joints (DAS28) ≤2,6 for at least 3 months under the same therapy. A B-mode and Power Doppler (PD) US examination was assessed by an experienced rheumatologist blinded to clinical data for 22 joints (wrists, 10 metacarpo-phalangeals, 10 proximal interphalangeals joints). A semi-quantitative scale running from 0 to 3 depending on US activity was attributed for each joint for PD. Patients were clinically controlled 3 to 6 months after performing the US. The variability of DAS28 was noted, it was considered significant if the p value <0,05. Results The mean age of the thirty patients was 48 years-old (25 females, 5 males). All of them were in remission according to DAS28 with an average of 2,03 [1,13-2,6]. US examination showed synovial hypertrophy in B-mode in 80% of patients and PD signals in 56,7% of patients. The follow-up control was performed on average after 4 months for 27 patients. The variation of DAS28 from baseline was significant (p<0,005). In fact the DAS28 increased of 0,75 [0,10-3,1] for 20 patients, among them 14 were no longer in remission. The DAS28 remained stable for 2 patients and decreased for 5 others. For patients who have reactivation of RA, the mean US PD scale was 4,4, while it was 1,1 for patients who remained in remission. However, the difference wasn't significant (p=0,12). Conclusions For patients in remission, persistent active synovitis in US is a risk factor for futur reactivation of the disease. PD monitoring in daily practice might lead to reduce disease relapses and structural damages. Disclosure of Interest : None declared DOI 10.1136/annrheumdis-2014-eular.5242</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/annrheumdis-2014-eular.5242</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>Kidlington: Elsevier Limited</publisher><ispartof>Annals of the rheumatic diseases, 2014-06, Vol.73 (Suppl 2), p.278</ispartof><rights>2014, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><rights>Copyright: 2014 (c) 2014, Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttp://ard.bmj.com/content/73/Suppl_2/278.1.full.pdf$$EPDF$$P50$$Gbmj$$H</linktopdf><linktohtml>$$Uhttp://ard.bmj.com/content/73/Suppl_2/278.1.full$$EHTML$$P50$$Gbmj$$H</linktohtml><link.rule.ids>114,115,314,776,780,3183,23550,27901,27902,77342,77373</link.rule.ids></links><search><creatorcontrib>Ben Abdelghani, K.</creatorcontrib><creatorcontrib>Miladi, S.</creatorcontrib><creatorcontrib>Souabni, L.</creatorcontrib><creatorcontrib>Kassab, S.</creatorcontrib><creatorcontrib>Chekili, S.</creatorcontrib><creatorcontrib>Laatar, A.</creatorcontrib><creatorcontrib>Zakraoui, L.</creatorcontrib><title>THU0274 Ultrasonographic Inflammatory Activity Predicts Relapse in Rheumatoid Arthritis in Remission</title><title>Annals of the rheumatic diseases</title><description>Background Remission is the current aim of treatment in rheumatoid arthritis (RA). Remission is ideally the absence of detectable disease and absence of structural and functional worsening over the time. Infra-clinical synovitis, detected by ultrasound, may persist in patients with remission leading to further structural damage. Objectives The aim of this study was to assess the frequency of relapse after clinical remission and the value of US to predict this relapse. Methods A prospective study of 30 patients followed-up for RA in remission was conducted. The remission was defined by a Disease Activity Score 28 joints (DAS28) ≤2,6 for at least 3 months under the same therapy. A B-mode and Power Doppler (PD) US examination was assessed by an experienced rheumatologist blinded to clinical data for 22 joints (wrists, 10 metacarpo-phalangeals, 10 proximal interphalangeals joints). A semi-quantitative scale running from 0 to 3 depending on US activity was attributed for each joint for PD. Patients were clinically controlled 3 to 6 months after performing the US. The variability of DAS28 was noted, it was considered significant if the p value <0,05. Results The mean age of the thirty patients was 48 years-old (25 females, 5 males). All of them were in remission according to DAS28 with an average of 2,03 [1,13-2,6]. US examination showed synovial hypertrophy in B-mode in 80% of patients and PD signals in 56,7% of patients. The follow-up control was performed on average after 4 months for 27 patients. The variation of DAS28 from baseline was significant (p<0,005). In fact the DAS28 increased of 0,75 [0,10-3,1] for 20 patients, among them 14 were no longer in remission. The DAS28 remained stable for 2 patients and decreased for 5 others. For patients who have reactivation of RA, the mean US PD scale was 4,4, while it was 1,1 for patients who remained in remission. However, the difference wasn't significant (p=0,12). Conclusions For patients in remission, persistent active synovitis in US is a risk factor for futur reactivation of the disease. PD monitoring in daily practice might lead to reduce disease relapses and structural damages. Disclosure of Interest : None declared DOI 10.1136/annrheumdis-2014-eular.5242</description><issn>0003-4967</issn><issn>1468-2060</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>BENPR</sourceid><recordid>eNqVkL1OwzAUhS0EEqXwDpE6p9hOHDtiqiqglSqBqma2bhyHusoftoPUjYUX5UlIWgZWpqt7dM79-RCaETwnJEruoWnsXvd1YVxIMYlD3Vdg54zG9AJNSJyIQU7wJZpgjKMwThN-jW6cOwwtFkRMULlbZZjy-PvzK6u8Bdc27ZuFbm9UsG7KCuoafGuPwUJ582H8MXi1ujDKu2CrK-icDkwTbMcjBp8pgoX1e2u8cSdd18Y50za36KqEyum73zpF2dPjbrkKNy_P6-ViE-aEchrGIFSpGYacpSAimihKIBdQ5owLEWvBUyhVMbxEGWhghKuUFxFOtKYshyKaotl5bmfb9147Lw9tb5thpSSc85SzCNPB9XB2Kds6Z3UpO2tqsEdJsBzByj9g5QhWnsDKEeyQTs7pvD78K_gDWqGHBg</recordid><startdate>201406</startdate><enddate>201406</enddate><creator>Ben Abdelghani, K.</creator><creator>Miladi, S.</creator><creator>Souabni, L.</creator><creator>Kassab, S.</creator><creator>Chekili, S.</creator><creator>Laatar, A.</creator><creator>Zakraoui, L.</creator><general>Elsevier Limited</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88I</scope><scope>8AF</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9-</scope><scope>K9.</scope><scope>LK8</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope></search><sort><creationdate>201406</creationdate><title>THU0274 Ultrasonographic Inflammatory Activity Predicts Relapse in Rheumatoid Arthritis in Remission</title><author>Ben Abdelghani, K. ; Miladi, S. ; Souabni, L. ; Kassab, S. ; Chekili, S. ; Laatar, A. ; Zakraoui, L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b1272-4a8cfe50ab59a8326c21ab8afb57884e879afcd06025aea517c97d306ee25bad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ben Abdelghani, K.</creatorcontrib><creatorcontrib>Miladi, S.</creatorcontrib><creatorcontrib>Souabni, L.</creatorcontrib><creatorcontrib>Kassab, S.</creatorcontrib><creatorcontrib>Chekili, S.</creatorcontrib><creatorcontrib>Laatar, A.</creatorcontrib><creatorcontrib>Zakraoui, L.</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><jtitle>Annals of the rheumatic diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ben Abdelghani, K.</au><au>Miladi, S.</au><au>Souabni, L.</au><au>Kassab, S.</au><au>Chekili, S.</au><au>Laatar, A.</au><au>Zakraoui, L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>THU0274 Ultrasonographic Inflammatory Activity Predicts Relapse in Rheumatoid Arthritis in Remission</atitle><jtitle>Annals of the rheumatic diseases</jtitle><date>2014-06</date><risdate>2014</risdate><volume>73</volume><issue>Suppl 2</issue><spage>278</spage><pages>278-</pages><issn>0003-4967</issn><eissn>1468-2060</eissn><coden>ARDIAO</coden><abstract>Background Remission is the current aim of treatment in rheumatoid arthritis (RA). Remission is ideally the absence of detectable disease and absence of structural and functional worsening over the time. Infra-clinical synovitis, detected by ultrasound, may persist in patients with remission leading to further structural damage. Objectives The aim of this study was to assess the frequency of relapse after clinical remission and the value of US to predict this relapse. Methods A prospective study of 30 patients followed-up for RA in remission was conducted. The remission was defined by a Disease Activity Score 28 joints (DAS28) ≤2,6 for at least 3 months under the same therapy. A B-mode and Power Doppler (PD) US examination was assessed by an experienced rheumatologist blinded to clinical data for 22 joints (wrists, 10 metacarpo-phalangeals, 10 proximal interphalangeals joints). A semi-quantitative scale running from 0 to 3 depending on US activity was attributed for each joint for PD. Patients were clinically controlled 3 to 6 months after performing the US. The variability of DAS28 was noted, it was considered significant if the p value <0,05. Results The mean age of the thirty patients was 48 years-old (25 females, 5 males). All of them were in remission according to DAS28 with an average of 2,03 [1,13-2,6]. US examination showed synovial hypertrophy in B-mode in 80% of patients and PD signals in 56,7% of patients. The follow-up control was performed on average after 4 months for 27 patients. The variation of DAS28 from baseline was significant (p<0,005). In fact the DAS28 increased of 0,75 [0,10-3,1] for 20 patients, among them 14 were no longer in remission. The DAS28 remained stable for 2 patients and decreased for 5 others. For patients who have reactivation of RA, the mean US PD scale was 4,4, while it was 1,1 for patients who remained in remission. However, the difference wasn't significant (p=0,12). Conclusions For patients in remission, persistent active synovitis in US is a risk factor for futur reactivation of the disease. PD monitoring in daily practice might lead to reduce disease relapses and structural damages. Disclosure of Interest : None declared DOI 10.1136/annrheumdis-2014-eular.5242</abstract><cop>Kidlington</cop><pub>Elsevier Limited</pub><doi>10.1136/annrheumdis-2014-eular.5242</doi></addata></record> |
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| title | THU0274 Ultrasonographic Inflammatory Activity Predicts Relapse in Rheumatoid Arthritis in Remission |
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