ADAMTS-7 forms a positive feedback loop with TNF-[alpha] in the pathogenesis of osteoarthritis

Objective To examine the expression of ADAMTS-7 during the progression of osteoarthritis (OA), defining its role in the pathogenesis of OA, and elucidating the molecular events involved. Methods ADAMTS-7 expression in cartilage of a rat OA model was assayed using immunohistochemistry. Cartilage-spec...

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Veröffentlicht in:	Annals of the rheumatic diseases 2014-08, Vol.73 (8), p.1575
Hauptverfasser:	Lai, Yongjie, Bai, Xiaohui, Zhao, Yunpeng, Tian, Qingyun, Liu, Ben, Lin, Edward A, Chen, Yuqing, Lee, Brendan, Appleton, C Thomas, Beier, Frank, Yu, Xiu-Ping, Liu, Chuan-ju
Format:	Artikel
Sprache:	eng
Schlagworte:	Arthritis Atherosclerosis Cardiovascular disease Cytokines Enzymes Extracellular matrix Feedback Methods Pathogenesis
Online-Zugang:	Volltext
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