The efficacy of canakinumab in the treatment of a patient with familial Mediterranean fever and longstanding destructive arthritis
Self-limited, non-destructive arthritis is a common clinical presentation of familial Mediterranean fever (FMF), while protracted, refractory to standard treatment arthritis is a rare manifestation of the disease, potentially resulting in severe damage and disability. 1 - 3 We report on a 25-year-ol...
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| Veröffentlicht in: | Annals of the rheumatic diseases 2011-07, Vol.70 (7), p.1347-1348 |
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| container_title | Annals of the rheumatic diseases |
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| creator | Mitroulis, Ioannis Skendros, Panagiotis Oikonomou, Anastasia Tzioufas, Athanasios G Ritis, Konstantinos |
| description | Self-limited, non-destructive arthritis is a common clinical presentation of familial Mediterranean fever (FMF), while protracted, refractory to standard treatment arthritis is a rare manifestation of the disease, potentially resulting in severe damage and disability. 1 - 3 We report on a 25-year-old woman with FMF, homozygous for the MEFV gene M694V mutation, and with longstanding articular involvement affecting her hips and her left knee, effectively treated with canakinumab. Long-term remission was not achieved, as indicated by the clinical findings and the elevated inflammatory parameters (erythrocyte sedimentation rate (ESR) and C reactive protein (CRP)) during the follow-up period. |
| doi_str_mv | 10.1136/ard.2010.146878 |
| format | Article |
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Long-term remission was not achieved, as indicated by the clinical findings and the elevated inflammatory parameters (erythrocyte sedimentation rate (ESR) and C reactive protein (CRP)) during the follow-up period.</description><identifier>ISSN: 0003-4967</identifier><identifier>EISSN: 1468-2060</identifier><identifier>DOI: 10.1136/ard.2010.146878</identifier><identifier>PMID: 21345814</identifier><identifier>CODEN: ARDIAO</identifier><language>eng</language><publisher>London: BMJ Publishing Group Ltd and European League Against Rheumatism</publisher><subject>Adult ; Antibodies, Monoclonal - therapeutic use ; Antirheumatic Agents - therapeutic use ; Arthritis ; Arthritis - drug therapy ; Biological and medical sciences ; Diseases of the osteoarticular system ; Familial Mediterranean Fever - drug therapy ; Female ; Humans ; Inflammatory joint diseases ; Interleukin-1beta - antagonists & inhibitors ; Malformations and congenital and or hereditary diseases involving bones. 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| ispartof | Annals of the rheumatic diseases, 2011-07, Vol.70 (7), p.1347-1348 |
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| subjects | Adult Antibodies, Monoclonal - therapeutic use Antirheumatic Agents - therapeutic use Arthritis Arthritis - drug therapy Biological and medical sciences Diseases of the osteoarticular system Familial Mediterranean Fever - drug therapy Female Humans Inflammatory joint diseases Interleukin-1beta - antagonists & inhibitors Malformations and congenital and or hereditary diseases involving bones. Joint deformations Medical sciences Miscellaneous. Osteoarticular involvement in other diseases |
| title | The efficacy of canakinumab in the treatment of a patient with familial Mediterranean fever and longstanding destructive arthritis |
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