Fruit peel polyphenols demonstrate substantial anti-tumour effects in the model of breast cancer

Purpose Fruit and vegetable intake is inversely correlated with cancer; thus, it is proposed that an extract of phytochemicals as present in whole fruits, vegetables, or grains may have anti-carcinogenic properties. Thus, the anti-tumour effects of fruit peel polyphenols (Flavin7) in the chemopreven...

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Veröffentlicht in:	European journal of nutrition 2016-04, Vol.55 (3), p.955-965
Hauptverfasser:	Kubatka, Peter, Kapinová, Andrea, Kello, Martin, Kruzliak, Peter, Kajo, Karol, Výbohová, Desanka, Mahmood, Silvia, Murin, Radovan, Viera, Tischlerová, Mojžiš, Ján, Zulli, Anthony, Péč, Martin, Adamkov, Marián, Kassayová, Monika, Bojková, Bianka, Stollárová, Nadežda, Dobrota, Dušan
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Phytogenic - analysis Antineoplastic Agents, Phytogenic - pharmacology Apoptosis - drug effects bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Caspase 3 - genetics Caspase 3 - metabolism Cell Proliferation - drug effects Chemistry Chemistry and Materials Science Disease Models, Animal DNA Fragmentation - drug effects Dose-Response Relationship, Drug Female Flavonoids - analysis Flavonoids - pharmacology Fruit - chemistry Humans Ki-67 Antigen - genetics Ki-67 Antigen - metabolism Mammary Neoplasms, Experimental - drug therapy MCF-7 Cells Methylnitrosourea - toxicity Nutrition Original Contribution Polyphenols - analysis Polyphenols - pharmacology Rats Stilbenes - analysis Stilbenes - pharmacology Tyrosine - analogs & derivatives Tyrosine - metabolism Vascular Endothelial Growth Factor Receptor-2 - genetics Vascular Endothelial Growth Factor Receptor-2 - metabolism
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