MicroRNA-184 Deregulated by the MicroRNA-21 Promotes Tumor Malignancy and Poor Outcomes in Non-small Cell Lung Cancer via Targeting CDC25A and c-Myc

Background MicroRNA (miR)-184 has been reported to have a dual role in human cancers. However, the role of miR-184 in non-small cell lung cancer (NSCLC) remains unclear. Methods Wild-type or mutant CDC25A promoters were constructed by PCR and site-directed mutagenesis to verify whether miR-184 could...

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Veröffentlicht in:	Annals of surgical oncology 2015-12, Vol.22 (Suppl 3), p.1532-1539
Hauptverfasser:	Lin, Tsang-Chi, Lin, Po-Lin, Cheng, Ya-Wen, Wu, Tzu-Chin, Chou, Ming-Chih, Chen, Chih-Yi, Lee, Huei
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology cdc25 Phosphatases - genetics cdc25 Phosphatases - metabolism Cell Movement Cell Proliferation Gene Expression Regulation, Neoplastic Humans Immunoenzyme Techniques Lung Neoplasms - genetics Lung Neoplasms - metabolism Lung Neoplasms - pathology Medicine Medicine & Public Health MicroRNAs - genetics Neoplasm Invasiveness Neoplasm Staging Oncology Prognosis Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Surgery Surgical Oncology Survival Rate Translational Research and Biomarkers Tumor Cells, Cultured
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