Targeted activation of CREB in reactive astrocytes is neuroprotective in focal acute cortical injury

The clinical challenge in acute injury as in traumatic brain injury (TBI) is to halt the delayed neuronal loss that occurs hours and days after the insult. Here we report that the activation of CREB‐dependent transcription in reactive astrocytes prevents secondary injury in cerebral cortex after exp...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Glia 2016-05, Vol.64 (5), p.853-874
Hauptverfasser:	Pardo, Luis, Schlüter, Agatha, Valor, Luis M., Barco, Angel, Giralt, Mercedes, Golbano, Arantxa, Hidalgo, Juan, Jia, Peilin, Zhao, Zhongming, Jové, Mariona, Portero-Otin, Manuel, Ruiz, Montserrat, Giménez-Llort, Lydia, Masgrau, Roser, Pujol, Aurora, Galea, Elena
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism astrocytes Astrocytes - drug effects Astrocytes - metabolism Brain Injuries - pathology Brain Injuries - therapy Cells, Cultured CREB CREB-Binding Protein - genetics CREB-Binding Protein - metabolism Disease Models, Animal Etoposide - metabolism Female Gene Expression Profiling Gene Expression Regulation - genetics Glial Fibrillary Acidic Protein - genetics Glial Fibrillary Acidic Protein - metabolism Inflammation - etiology Inflammation - prevention & control Male Meta-Analysis as Topic Mice Mice, Inbred C57BL Mice, Transgenic mitochondria Mitochondria - metabolism Molecular Chaperones - genetics Molecular Chaperones - metabolism Neurofilament Proteins - metabolism neuroinflammation Rodents Traumatic brain injury
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!