Two-Step Synthesis of a Clickable Photoaffinity Probe from an Anticancer Saponin OSW-1 and its Photochemical Reactivity

OSW‐1 is a highly potent anticancer saponin with an unknown mechanism of action that is distinct from the currently used chemotherapeutic agents. Toward investigation of its binding proteins, we designed and synthesized a clickable photoaffinity probe from OSW‐1 and characterized its photochemical r...

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Veröffentlicht in:	Asian journal of organic chemistry 2016-03, Vol.5 (3), p.330-334
Hauptverfasser:	Yamada, Rika, Hiraizumi, Masato, Narita, Sho, Sakurai, Kaori
Format:	Artikel
Sprache:	eng
Schlagworte:	antitumor agent Cancer click chemistry Organic chemistry OSW-1 photoaffinity probes saponins site-selective acylation
Online-Zugang:	Volltext
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