Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer
This study aims to evaluate and verify the relationship between the immunoexpression of hMSH2, p53 and p21 in actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Forty AC and 40 SCC cases were submitted to immunoperoxidase method and quantitatively analyzed. Expression was comp...
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creator | Lopes, Maria Luiza Diniz de Sousa de Oliveira, Denise Hélen Imaculada Pereira Sarmento, Dmitry José de Santana Queiroz, Lélia Maria Guedes Miguel, Márcia Cristina da Costa da Silveira, Éricka Janine Dantas |
description | This study aims to evaluate and verify the relationship between the immunoexpression of hMSH2, p53 and p21 in actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Forty AC and 40 SCC cases were submitted to immunoperoxidase method and quantitatively analyzed. Expression was compared by Mann–Whitney test, Student
t
test or one-way ANOVA. To correlate the variables, Pearson’s correlation coefficient was calculated. The expression of p53 and p21 showed no significant differences between histopathological grades of AC or lower lip SCC (
p
> 0.05). Immunoexpression of p53 was higher in SCC than in AC (
p
|
doi_str_mv | 10.1007/s00403-016-1625-z |
format | Article |
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t
test or one-way ANOVA. To correlate the variables, Pearson’s correlation coefficient was calculated. The expression of p53 and p21 showed no significant differences between histopathological grades of AC or lower lip SCC (
p
> 0.05). Immunoexpression of p53 was higher in SCC than in AC (
p
< 0.001), while p21 expression was more observed in AC when compared to SCC group (
p
= 0.006). The AC group revealed an inverse correlation between p53 and hMSH2 expression (
r
= −0.30,
p
= 0.006). Alterations in p53 and p21 expression suggest that these proteins are involved in lower lip carcinogenesis. Moreover, p53 and hMSH2 seem to be interrelated in early events of this process.</description><identifier>ISSN: 0340-3696</identifier><identifier>EISSN: 1432-069X</identifier><identifier>DOI: 10.1007/s00403-016-1625-z</identifier><identifier>PMID: 26842232</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Carcinogenesis - metabolism ; Carcinogenesis - pathology ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Cell Cycle Proteins - metabolism ; Cheilitis - metabolism ; Cheilitis - pathology ; Cyclin-Dependent Kinase Inhibitor p21 - metabolism ; Dermatology ; Female ; Humans ; Immunohistochemistry ; Lip - pathology ; Lip Neoplasms - metabolism ; Lip Neoplasms - pathology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; MutS Homolog 2 Protein - metabolism ; Neoplasm Grading ; Original Paper ; Retrospective Studies ; Tumor Suppressor Protein p53 - metabolism</subject><ispartof>Archives of Dermatological Research, 2016-04, Vol.308 (3), p.165-171</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-a9550622868cd1a03b3a6d993dd5747b8c8f23d242b75108e6eaca3cdf442f343</citedby><cites>FETCH-LOGICAL-c415t-a9550622868cd1a03b3a6d993dd5747b8c8f23d242b75108e6eaca3cdf442f343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00403-016-1625-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00403-016-1625-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26842232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lopes, Maria Luiza Diniz de Sousa</creatorcontrib><creatorcontrib>de Oliveira, Denise Hélen Imaculada Pereira</creatorcontrib><creatorcontrib>Sarmento, Dmitry José de Santana</creatorcontrib><creatorcontrib>Queiroz, Lélia Maria Guedes</creatorcontrib><creatorcontrib>Miguel, Márcia Cristina da Costa</creatorcontrib><creatorcontrib>da Silveira, Éricka Janine Dantas</creatorcontrib><title>Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer</title><title>Archives of Dermatological Research</title><addtitle>Arch Dermatol Res</addtitle><addtitle>Arch Dermatol Res</addtitle><description>This study aims to evaluate and verify the relationship between the immunoexpression of hMSH2, p53 and p21 in actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Forty AC and 40 SCC cases were submitted to immunoperoxidase method and quantitatively analyzed. Expression was compared by Mann–Whitney test, Student
t
test or one-way ANOVA. To correlate the variables, Pearson’s correlation coefficient was calculated. The expression of p53 and p21 showed no significant differences between histopathological grades of AC or lower lip SCC (
p
> 0.05). Immunoexpression of p53 was higher in SCC than in AC (
p
< 0.001), while p21 expression was more observed in AC when compared to SCC group (
p
= 0.006). The AC group revealed an inverse correlation between p53 and hMSH2 expression (
r
= −0.30,
p
= 0.006). Alterations in p53 and p21 expression suggest that these proteins are involved in lower lip carcinogenesis. Moreover, p53 and hMSH2 seem to be interrelated in early events of this process.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Carcinogenesis - metabolism</subject><subject>Carcinogenesis - pathology</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cheilitis - metabolism</subject><subject>Cheilitis - pathology</subject><subject>Cyclin-Dependent Kinase Inhibitor p21 - metabolism</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lip - pathology</subject><subject>Lip Neoplasms - metabolism</subject><subject>Lip Neoplasms - pathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>MutS Homolog 2 Protein - metabolism</subject><subject>Neoplasm Grading</subject><subject>Original Paper</subject><subject>Retrospective Studies</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><issn>0340-3696</issn><issn>1432-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LAzEQhoMottT-AC8S8BydfGyye5SiVqh40IK3kM1mbWTN1mSLtL_eLVvFi3OZw7wfw4PQOYUrCqCuE4AAToBKQiXLyO4IjangjIAsXo_RGLgAwmUhR2ia0jv0o0AwUKdoxGQuGONsjJazNkbXmM63AZeu-3IuYOuaBtutbRxex7ZzPiRsQoVXj89zhn3AxnY-eIvtyvnGd344N36NrQnWxTN0UpsmuelhT9Dy7vZlNieLp_uH2c2CWEGzjpgiy0AylsvcVtQAL7mRVVHwqsqUUGVu85rxiglWqoxC7qQz1nBb1UKwmgs-QZdDbv_m58alTr-3mxj6Sk2VEpRxJfJeRQeVjW1K0dV6Hf2HiVtNQe9Z6oGl7lnqPUu96z0Xh-RN-eGqX8cPuV7ABkHqT-HNxT_V_6Z-A2vKfiI</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Lopes, Maria Luiza Diniz de Sousa</creator><creator>de Oliveira, Denise Hélen Imaculada Pereira</creator><creator>Sarmento, Dmitry José de Santana</creator><creator>Queiroz, Lélia Maria Guedes</creator><creator>Miguel, Márcia Cristina da Costa</creator><creator>da Silveira, Éricka Janine Dantas</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20160401</creationdate><title>Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer</title><author>Lopes, Maria Luiza Diniz de Sousa ; de Oliveira, Denise Hélen Imaculada Pereira ; Sarmento, Dmitry José de Santana ; Queiroz, Lélia Maria Guedes ; Miguel, Márcia Cristina da Costa ; da Silveira, Éricka Janine Dantas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-a9550622868cd1a03b3a6d993dd5747b8c8f23d242b75108e6eaca3cdf442f343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>Carcinogenesis - metabolism</topic><topic>Carcinogenesis - pathology</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Cheilitis - metabolism</topic><topic>Cheilitis - pathology</topic><topic>Cyclin-Dependent Kinase Inhibitor p21 - metabolism</topic><topic>Dermatology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lip - pathology</topic><topic>Lip Neoplasms - metabolism</topic><topic>Lip Neoplasms - pathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>MutS Homolog 2 Protein - metabolism</topic><topic>Neoplasm Grading</topic><topic>Original Paper</topic><topic>Retrospective Studies</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lopes, Maria Luiza Diniz de Sousa</creatorcontrib><creatorcontrib>de Oliveira, Denise Hélen Imaculada Pereira</creatorcontrib><creatorcontrib>Sarmento, Dmitry José de Santana</creatorcontrib><creatorcontrib>Queiroz, Lélia Maria Guedes</creatorcontrib><creatorcontrib>Miguel, Márcia Cristina da Costa</creatorcontrib><creatorcontrib>da Silveira, Éricka Janine Dantas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Archives of Dermatological Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lopes, Maria Luiza Diniz de Sousa</au><au>de Oliveira, Denise Hélen Imaculada Pereira</au><au>Sarmento, Dmitry José de Santana</au><au>Queiroz, Lélia Maria Guedes</au><au>Miguel, Márcia Cristina da Costa</au><au>da Silveira, Éricka Janine Dantas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer</atitle><jtitle>Archives of Dermatological Research</jtitle><stitle>Arch Dermatol Res</stitle><addtitle>Arch Dermatol Res</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>308</volume><issue>3</issue><spage>165</spage><epage>171</epage><pages>165-171</pages><issn>0340-3696</issn><eissn>1432-069X</eissn><abstract>This study aims to evaluate and verify the relationship between the immunoexpression of hMSH2, p53 and p21 in actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Forty AC and 40 SCC cases were submitted to immunoperoxidase method and quantitatively analyzed. Expression was compared by Mann–Whitney test, Student
t
test or one-way ANOVA. To correlate the variables, Pearson’s correlation coefficient was calculated. The expression of p53 and p21 showed no significant differences between histopathological grades of AC or lower lip SCC (
p
> 0.05). Immunoexpression of p53 was higher in SCC than in AC (
p
< 0.001), while p21 expression was more observed in AC when compared to SCC group (
p
= 0.006). The AC group revealed an inverse correlation between p53 and hMSH2 expression (
r
= −0.30,
p
= 0.006). Alterations in p53 and p21 expression suggest that these proteins are involved in lower lip carcinogenesis. Moreover, p53 and hMSH2 seem to be interrelated in early events of this process.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26842232</pmid><doi>10.1007/s00403-016-1625-z</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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subjects | Adult Aged Aged, 80 and over Analysis of Variance Carcinogenesis - metabolism Carcinogenesis - pathology Carcinoma, Squamous Cell - metabolism Carcinoma, Squamous Cell - pathology Cell Cycle Proteins - metabolism Cheilitis - metabolism Cheilitis - pathology Cyclin-Dependent Kinase Inhibitor p21 - metabolism Dermatology Female Humans Immunohistochemistry Lip - pathology Lip Neoplasms - metabolism Lip Neoplasms - pathology Male Medicine Medicine & Public Health Middle Aged MutS Homolog 2 Protein - metabolism Neoplasm Grading Original Paper Retrospective Studies Tumor Suppressor Protein p53 - metabolism |
title | Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer |
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