Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer

This study aims to evaluate and verify the relationship between the immunoexpression of hMSH2, p53 and p21 in actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Forty AC and 40 SCC cases were submitted to immunoperoxidase method and quantitatively analyzed. Expression was comp...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Archives of Dermatological Research 2016-04, Vol.308 (3), p.165-171
Hauptverfasser: Lopes, Maria Luiza Diniz de Sousa, de Oliveira, Denise Hélen Imaculada Pereira, Sarmento, Dmitry José de Santana, Queiroz, Lélia Maria Guedes, Miguel, Márcia Cristina da Costa, da Silveira, Éricka Janine Dantas
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 171
container_issue 3
container_start_page 165
container_title Archives of Dermatological Research
container_volume 308
creator Lopes, Maria Luiza Diniz de Sousa
de Oliveira, Denise Hélen Imaculada Pereira
Sarmento, Dmitry José de Santana
Queiroz, Lélia Maria Guedes
Miguel, Márcia Cristina da Costa
da Silveira, Éricka Janine Dantas
description This study aims to evaluate and verify the relationship between the immunoexpression of hMSH2, p53 and p21 in actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Forty AC and 40 SCC cases were submitted to immunoperoxidase method and quantitatively analyzed. Expression was compared by Mann–Whitney test, Student t test or one-way ANOVA. To correlate the variables, Pearson’s correlation coefficient was calculated. The expression of p53 and p21 showed no significant differences between histopathological grades of AC or lower lip SCC ( p  > 0.05). Immunoexpression of p53 was higher in SCC than in AC ( p  
doi_str_mv 10.1007/s00403-016-1625-z
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1774123748</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3988840451</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-a9550622868cd1a03b3a6d993dd5747b8c8f23d242b75108e6eaca3cdf442f343</originalsourceid><addsrcrecordid>eNp1kE1LAzEQhoMottT-AC8S8BydfGyye5SiVqh40IK3kM1mbWTN1mSLtL_eLVvFi3OZw7wfw4PQOYUrCqCuE4AAToBKQiXLyO4IjangjIAsXo_RGLgAwmUhR2ia0jv0o0AwUKdoxGQuGONsjJazNkbXmM63AZeu-3IuYOuaBtutbRxex7ZzPiRsQoVXj89zhn3AxnY-eIvtyvnGd344N36NrQnWxTN0UpsmuelhT9Dy7vZlNieLp_uH2c2CWEGzjpgiy0AylsvcVtQAL7mRVVHwqsqUUGVu85rxiglWqoxC7qQz1nBb1UKwmgs-QZdDbv_m58alTr-3mxj6Sk2VEpRxJfJeRQeVjW1K0dV6Hf2HiVtNQe9Z6oGl7lnqPUu96z0Xh-RN-eGqX8cPuV7ABkHqT-HNxT_V_6Z-A2vKfiI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1774123748</pqid></control><display><type>article</type><title>Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Lopes, Maria Luiza Diniz de Sousa ; de Oliveira, Denise Hélen Imaculada Pereira ; Sarmento, Dmitry José de Santana ; Queiroz, Lélia Maria Guedes ; Miguel, Márcia Cristina da Costa ; da Silveira, Éricka Janine Dantas</creator><creatorcontrib>Lopes, Maria Luiza Diniz de Sousa ; de Oliveira, Denise Hélen Imaculada Pereira ; Sarmento, Dmitry José de Santana ; Queiroz, Lélia Maria Guedes ; Miguel, Márcia Cristina da Costa ; da Silveira, Éricka Janine Dantas</creatorcontrib><description>This study aims to evaluate and verify the relationship between the immunoexpression of hMSH2, p53 and p21 in actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Forty AC and 40 SCC cases were submitted to immunoperoxidase method and quantitatively analyzed. Expression was compared by Mann–Whitney test, Student t test or one-way ANOVA. To correlate the variables, Pearson’s correlation coefficient was calculated. The expression of p53 and p21 showed no significant differences between histopathological grades of AC or lower lip SCC ( p  &gt; 0.05). Immunoexpression of p53 was higher in SCC than in AC ( p  &lt; 0.001), while p21 expression was more observed in AC when compared to SCC group ( p  = 0.006). The AC group revealed an inverse correlation between p53 and hMSH2 expression ( r  = −0.30, p  = 0.006). Alterations in p53 and p21 expression suggest that these proteins are involved in lower lip carcinogenesis. Moreover, p53 and hMSH2 seem to be interrelated in early events of this process.</description><identifier>ISSN: 0340-3696</identifier><identifier>EISSN: 1432-069X</identifier><identifier>DOI: 10.1007/s00403-016-1625-z</identifier><identifier>PMID: 26842232</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Analysis of Variance ; Carcinogenesis - metabolism ; Carcinogenesis - pathology ; Carcinoma, Squamous Cell - metabolism ; Carcinoma, Squamous Cell - pathology ; Cell Cycle Proteins - metabolism ; Cheilitis - metabolism ; Cheilitis - pathology ; Cyclin-Dependent Kinase Inhibitor p21 - metabolism ; Dermatology ; Female ; Humans ; Immunohistochemistry ; Lip - pathology ; Lip Neoplasms - metabolism ; Lip Neoplasms - pathology ; Male ; Medicine ; Medicine &amp; Public Health ; Middle Aged ; MutS Homolog 2 Protein - metabolism ; Neoplasm Grading ; Original Paper ; Retrospective Studies ; Tumor Suppressor Protein p53 - metabolism</subject><ispartof>Archives of Dermatological Research, 2016-04, Vol.308 (3), p.165-171</ispartof><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-a9550622868cd1a03b3a6d993dd5747b8c8f23d242b75108e6eaca3cdf442f343</citedby><cites>FETCH-LOGICAL-c415t-a9550622868cd1a03b3a6d993dd5747b8c8f23d242b75108e6eaca3cdf442f343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00403-016-1625-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00403-016-1625-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26842232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lopes, Maria Luiza Diniz de Sousa</creatorcontrib><creatorcontrib>de Oliveira, Denise Hélen Imaculada Pereira</creatorcontrib><creatorcontrib>Sarmento, Dmitry José de Santana</creatorcontrib><creatorcontrib>Queiroz, Lélia Maria Guedes</creatorcontrib><creatorcontrib>Miguel, Márcia Cristina da Costa</creatorcontrib><creatorcontrib>da Silveira, Éricka Janine Dantas</creatorcontrib><title>Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer</title><title>Archives of Dermatological Research</title><addtitle>Arch Dermatol Res</addtitle><addtitle>Arch Dermatol Res</addtitle><description>This study aims to evaluate and verify the relationship between the immunoexpression of hMSH2, p53 and p21 in actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Forty AC and 40 SCC cases were submitted to immunoperoxidase method and quantitatively analyzed. Expression was compared by Mann–Whitney test, Student t test or one-way ANOVA. To correlate the variables, Pearson’s correlation coefficient was calculated. The expression of p53 and p21 showed no significant differences between histopathological grades of AC or lower lip SCC ( p  &gt; 0.05). Immunoexpression of p53 was higher in SCC than in AC ( p  &lt; 0.001), while p21 expression was more observed in AC when compared to SCC group ( p  = 0.006). The AC group revealed an inverse correlation between p53 and hMSH2 expression ( r  = −0.30, p  = 0.006). Alterations in p53 and p21 expression suggest that these proteins are involved in lower lip carcinogenesis. Moreover, p53 and hMSH2 seem to be interrelated in early events of this process.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Analysis of Variance</subject><subject>Carcinogenesis - metabolism</subject><subject>Carcinogenesis - pathology</subject><subject>Carcinoma, Squamous Cell - metabolism</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell Cycle Proteins - metabolism</subject><subject>Cheilitis - metabolism</subject><subject>Cheilitis - pathology</subject><subject>Cyclin-Dependent Kinase Inhibitor p21 - metabolism</subject><subject>Dermatology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lip - pathology</subject><subject>Lip Neoplasms - metabolism</subject><subject>Lip Neoplasms - pathology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine &amp; Public Health</subject><subject>Middle Aged</subject><subject>MutS Homolog 2 Protein - metabolism</subject><subject>Neoplasm Grading</subject><subject>Original Paper</subject><subject>Retrospective Studies</subject><subject>Tumor Suppressor Protein p53 - metabolism</subject><issn>0340-3696</issn><issn>1432-069X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LAzEQhoMottT-AC8S8BydfGyye5SiVqh40IK3kM1mbWTN1mSLtL_eLVvFi3OZw7wfw4PQOYUrCqCuE4AAToBKQiXLyO4IjangjIAsXo_RGLgAwmUhR2ia0jv0o0AwUKdoxGQuGONsjJazNkbXmM63AZeu-3IuYOuaBtutbRxex7ZzPiRsQoVXj89zhn3AxnY-eIvtyvnGd344N36NrQnWxTN0UpsmuelhT9Dy7vZlNieLp_uH2c2CWEGzjpgiy0AylsvcVtQAL7mRVVHwqsqUUGVu85rxiglWqoxC7qQz1nBb1UKwmgs-QZdDbv_m58alTr-3mxj6Sk2VEpRxJfJeRQeVjW1K0dV6Hf2HiVtNQe9Z6oGl7lnqPUu96z0Xh-RN-eGqX8cPuV7ABkHqT-HNxT_V_6Z-A2vKfiI</recordid><startdate>20160401</startdate><enddate>20160401</enddate><creator>Lopes, Maria Luiza Diniz de Sousa</creator><creator>de Oliveira, Denise Hélen Imaculada Pereira</creator><creator>Sarmento, Dmitry José de Santana</creator><creator>Queiroz, Lélia Maria Guedes</creator><creator>Miguel, Márcia Cristina da Costa</creator><creator>da Silveira, Éricka Janine Dantas</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope></search><sort><creationdate>20160401</creationdate><title>Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer</title><author>Lopes, Maria Luiza Diniz de Sousa ; de Oliveira, Denise Hélen Imaculada Pereira ; Sarmento, Dmitry José de Santana ; Queiroz, Lélia Maria Guedes ; Miguel, Márcia Cristina da Costa ; da Silveira, Éricka Janine Dantas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-a9550622868cd1a03b3a6d993dd5747b8c8f23d242b75108e6eaca3cdf442f343</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Analysis of Variance</topic><topic>Carcinogenesis - metabolism</topic><topic>Carcinogenesis - pathology</topic><topic>Carcinoma, Squamous Cell - metabolism</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell Cycle Proteins - metabolism</topic><topic>Cheilitis - metabolism</topic><topic>Cheilitis - pathology</topic><topic>Cyclin-Dependent Kinase Inhibitor p21 - metabolism</topic><topic>Dermatology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lip - pathology</topic><topic>Lip Neoplasms - metabolism</topic><topic>Lip Neoplasms - pathology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine &amp; Public Health</topic><topic>Middle Aged</topic><topic>MutS Homolog 2 Protein - metabolism</topic><topic>Neoplasm Grading</topic><topic>Original Paper</topic><topic>Retrospective Studies</topic><topic>Tumor Suppressor Protein p53 - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lopes, Maria Luiza Diniz de Sousa</creatorcontrib><creatorcontrib>de Oliveira, Denise Hélen Imaculada Pereira</creatorcontrib><creatorcontrib>Sarmento, Dmitry José de Santana</creatorcontrib><creatorcontrib>Queiroz, Lélia Maria Guedes</creatorcontrib><creatorcontrib>Miguel, Márcia Cristina da Costa</creatorcontrib><creatorcontrib>da Silveira, Éricka Janine Dantas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><jtitle>Archives of Dermatological Research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lopes, Maria Luiza Diniz de Sousa</au><au>de Oliveira, Denise Hélen Imaculada Pereira</au><au>Sarmento, Dmitry José de Santana</au><au>Queiroz, Lélia Maria Guedes</au><au>Miguel, Márcia Cristina da Costa</au><au>da Silveira, Éricka Janine Dantas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer</atitle><jtitle>Archives of Dermatological Research</jtitle><stitle>Arch Dermatol Res</stitle><addtitle>Arch Dermatol Res</addtitle><date>2016-04-01</date><risdate>2016</risdate><volume>308</volume><issue>3</issue><spage>165</spage><epage>171</epage><pages>165-171</pages><issn>0340-3696</issn><eissn>1432-069X</eissn><abstract>This study aims to evaluate and verify the relationship between the immunoexpression of hMSH2, p53 and p21 in actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Forty AC and 40 SCC cases were submitted to immunoperoxidase method and quantitatively analyzed. Expression was compared by Mann–Whitney test, Student t test or one-way ANOVA. To correlate the variables, Pearson’s correlation coefficient was calculated. The expression of p53 and p21 showed no significant differences between histopathological grades of AC or lower lip SCC ( p  &gt; 0.05). Immunoexpression of p53 was higher in SCC than in AC ( p  &lt; 0.001), while p21 expression was more observed in AC when compared to SCC group ( p  = 0.006). The AC group revealed an inverse correlation between p53 and hMSH2 expression ( r  = −0.30, p  = 0.006). Alterations in p53 and p21 expression suggest that these proteins are involved in lower lip carcinogenesis. Moreover, p53 and hMSH2 seem to be interrelated in early events of this process.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26842232</pmid><doi>10.1007/s00403-016-1625-z</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 0340-3696
ispartof Archives of Dermatological Research, 2016-04, Vol.308 (3), p.165-171
issn 0340-3696
1432-069X
language eng
recordid cdi_proquest_journals_1774123748
source MEDLINE; SpringerNature Journals
subjects Adult
Aged
Aged, 80 and over
Analysis of Variance
Carcinogenesis - metabolism
Carcinogenesis - pathology
Carcinoma, Squamous Cell - metabolism
Carcinoma, Squamous Cell - pathology
Cell Cycle Proteins - metabolism
Cheilitis - metabolism
Cheilitis - pathology
Cyclin-Dependent Kinase Inhibitor p21 - metabolism
Dermatology
Female
Humans
Immunohistochemistry
Lip - pathology
Lip Neoplasms - metabolism
Lip Neoplasms - pathology
Male
Medicine
Medicine & Public Health
Middle Aged
MutS Homolog 2 Protein - metabolism
Neoplasm Grading
Original Paper
Retrospective Studies
Tumor Suppressor Protein p53 - metabolism
title Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-29T08%3A56%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Correlation%20between%20cell%20cycle%20proteins%20and%20hMSH2%20in%20actinic%20cheilitis%20and%20lip%20cancer&rft.jtitle=Archives%20of%20Dermatological%20Research&rft.au=Lopes,%20Maria%20Luiza%20Diniz%20de%20Sousa&rft.date=2016-04-01&rft.volume=308&rft.issue=3&rft.spage=165&rft.epage=171&rft.pages=165-171&rft.issn=0340-3696&rft.eissn=1432-069X&rft_id=info:doi/10.1007/s00403-016-1625-z&rft_dat=%3Cproquest_cross%3E3988840451%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1774123748&rft_id=info:pmid/26842232&rfr_iscdi=true