Global Tests in Evaluation of the Function of Proand Anticoagulant Systems: Present and Future

Comparative analysis of the effectiveness of global tests for evaluation of the blood coagulation systems demonstrated the possibility of obtaining express data on hemostasis stages I-II and III when working with native substrate (whole blood). Changes in viscous characteristics of the whole blood r...

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Veröffentlicht in:Bulletin of experimental biology and medicine 2015-06, Vol.159 (2), p.205-208
Hauptverfasser: Udut, V. V., Tyutrin, I. I., Solov’ev, M. A., Klimenkova, V. F., Malyugin, E. F., Karchagina, O. S., Borodulina, E. V., Turenko, A. V.
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container_end_page 208
container_issue 2
container_start_page 205
container_title Bulletin of experimental biology and medicine
container_volume 159
creator Udut, V. V.
Tyutrin, I. I.
Solov’ev, M. A.
Klimenkova, V. F.
Malyugin, E. F.
Karchagina, O. S.
Borodulina, E. V.
Turenko, A. V.
description Comparative analysis of the effectiveness of global tests for evaluation of the blood coagulation systems demonstrated the possibility of obtaining express data on hemostasis stages I-II and III when working with native substrate (whole blood). Changes in viscous characteristics of the whole blood recorded ex vivo during hemocoagulation allowed us to propose the concept of permanency of fibrinogenesis as the obligatory in vivo process determining the hemostatic potential, an integral characteristic of the hemocoagulation cycle providing sufficient blood fluidity and limiting extravasation of blood components under conditions of permeability disturbances and damage to the vascular wall.
doi_str_mv 10.1007/s10517-015-2923-8
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subjects Biomedical and Life Sciences
Biomedicine
Cell Biology
Internal Medicine
Laboratory Medicine
Pathology
title Global Tests in Evaluation of the Function of Proand Anticoagulant Systems: Present and Future
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