Interaction of TAPBPR, a tapasin homolog, with MHC-I molecules promotes peptide editing

Peptide loading of major histocompatibility complex class I (MHC-I) molecules is central to antigen presentation, self-tolerance, and CD8⁺ T-cell activation. TAP binding protein, related (TAPBPR), a widely expressed tapasin homolog, is not part of the classical MHC-I peptide-loading complex (PLC). U...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2016-02, Vol.113 (8), p.E1006-E1015
Hauptverfasser:	Morozov, Giora I., Zhao, Huaying, Mage, Michael G., Boyd, Lisa F., Jiang, Jiansheng, Dolan, Michael A., Venna, Ramesh, Norcross, Michael A., McMurtrey, Curtis P., Hildebrand, William, Schuck, Peter, Natarajan, Kannan, Margulies, David H.
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Animals Antigen Presentation Biological Sciences Cell Line Drosophila melanogaster Experiments Fluorescence HLA-A2 Antigen - genetics HLA-A2 Antigen - immunology Humans Immunoglobulins - genetics Immunoglobulins - immunology major histocompatibility complex Membrane Proteins - genetics Membrane Proteins - immunology Molecules peptide loading Peptides Peptides - genetics Peptides - immunology PNAS Plus protein interactions Proteins SAXS
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