NS11821, a partial subtype-selective GABA^sub A^ agonist, elicits selective effects on the central nervous system in randomized controlled trial with healthy subjects

NS11821 is a partial GABA... agonist with relatively dominant α... and α... subtype efficacy but negligible α... agonism. This first-in-human study was performed in healthy male subjects using a single-dose, parallel, double blind, placebo-controlled, randomized, dose-escalation study design. In tot...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Journal of psychopharmacology (Oxford) 2016-03, Vol.30 (3), p.253
Hauptverfasser:	Zuiker, Rob GJA, Chen, Xia, Østerberg, Ole, Mirza, Naheed R, Muglia, Pierandrea, de Kam, Marieke, Klaassen, Erica S, van Gerven, MA
Format:	Artikel
Sprache:	eng
Schlagworte:	Clinical trials Drug dosages Nervous system Pharmacology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!