Nuclear factor [kappa]B up-regulation of CCAAT/enhancer-binding protein [beta] mediates hepatocyte resistance to tumor necrosis factor [alpha] toxicity

The sensitization of hepatocytes to cell death from tumor necrosis factor [alpha] (TNF[alpha]) underlies many forms of hepatic injury, including that from toxins. Critical for hepatocyte resistance to TNF[alpha] toxicity is activation of nuclear factor [kappa]B (NF-[kappa]B) signaling, which prevent...

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Veröffentlicht in:	Hepatology (Baltimore, Md.) Md.), 2010-12, Vol.52 (6), p.2118
Hauptverfasser:	Wang, Yongjun, Singh, Rajat, Xiang, Youqing, Greenbaum, Linda E, Czaja, Mark J
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Gangrene Hepatology Kinases Proteins Toxicity Tumor necrosis factor-TNF
Online-Zugang:	Volltext
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