SPANphos Ligands in Palladium-Catalyzed Asymmetric Fluorination

The synthesis of new enantiopure wide‐bite‐angle diphosphanes is described as well as their use in the palladium‐catalyzed asymmetric fluorination of α‐cyanoacetates. Enantiomeric excesses up to 93 % were obtained when Pd(OAc)2‐SPANphos was used as catalyst for the fluorination of ethyl 2‐cyano‐2‐ph...

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Veröffentlicht in:	European journal of organic chemistry 2012-09, Vol.2012 (25), p.4844-4852
Hauptverfasser:	Jacquet, Olivier, Clément, Nicolas D., Blanco, Carolina, Belmonte, Marta Martinez, Benet-Buchholz, Jordi, van Leeuwen, Piet W. N. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Asymmetric catalysis Catalysis Catalysts: preparations and properties Chemistry Exact sciences and technology Fluorine General and physical chemistry Halogenation Ligand design Palladium Theory of reactions, general kinetics. Catalysis. Nomenclature, chemical documentation, computer chemistry
Online-Zugang:	Volltext
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