Fixing an irrelevant TCR[alpha] chain reveals the importance of TCR[beta] diversity for optimal TCR[alpha][beta] pairing and function of virus-specific CD8+ T cells

TCR repertoire diversity can influence the efficacy of CD8+ T-cell populations, with greater breadth eliciting better protection. We analyzed TCR[beta] diversity and functional capacity for influenza-specific CD8+ T cells expressing a single TCR[alpha] chain. Mice (A7) transgenic for the H2KbOVA257-...

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Veröffentlicht in:	European journal of immunology 2010-09, Vol.40 (9), p.2470
Hauptverfasser:	Valkenburg, Sophie A, Day, E Bridie, Swan, Natasha G, Croom, Hayley A, Carbone, Francis R, Doherty, Peter C, Turner, Stephen J, Kedzierska, Katherine
Format:	Artikel
Sprache:	eng
Schlagworte:	Lymphocytes T cell receptors
Online-Zugang:	Volltext
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