Dimedone-catalyzed Addition of Amines into Cyano Group： Facile Synthesis of Thiazol-2-yl Substituted E-Acrylonitriles
An efficient dimedone-catalyzed synthesis of highly functionalized thiazol-2-yl substituted E-acrylonitrile derivatives has been established through two-step reaction of a-thiocyanate ketones with malononitrile and amines. The a-thiocyanate ketones were subjected with malononitrile to provide thiazo...
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| Veröffentlicht in: | Chinese journal of chemistry 2012-07, Vol.30 (7), p.1617-1623 |
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| container_issue | 7 |
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| container_title | Chinese journal of chemistry |
| container_volume | 30 |
| creator | 朱伟军 屠兴超 冯惠 屠蔓苏 姜波 吴飞跃 屠树江 |
| description | An efficient dimedone-catalyzed synthesis of highly functionalized thiazol-2-yl substituted E-acrylonitrile derivatives has been established through two-step reaction of a-thiocyanate ketones with malononitrile and amines. The a-thiocyanate ketones were subjected with malononitrile to provide thiazol-2-ylidenemalononitrile derivatives, followed with various amines in the presence of dimedone to yield the final thiazol-2-yl substituted acrylonitrile derivatives. |
| doi_str_mv | 10.1002/cjoc.201100719 |
| format | Article |
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| identifier | ISSN: 1001-604X |
| ispartof | Chinese journal of chemistry, 2012-07, Vol.30 (7), p.1617-1623 |
| issn | 1001-604X 1614-7065 |
| language | eng |
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| source | Wiley Online Library All Journals |
| subjects | addition reaction dimedone-catalyzed synthesis E-acrylonitriles heterocycles microwave heating 丙烯腈 两步反应 催化合成 噻唑 氰基 胺 衍生物 酮 |
| title | Dimedone-catalyzed Addition of Amines into Cyano Group： Facile Synthesis of Thiazol-2-yl Substituted E-Acrylonitriles |
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