Conformational Selection of the AGAIAM Heparin Pentasaccharide when Bound to the Fibroblast Growth Factor Receptor

The interaction of the synthetic pentasaccharide AGA*IAM (GlcNS,6S‐GlcA‐GlcNS,3S,6S‐IdoA2S‐GlcNS,6S‐Me) with the extracellular Ig2 domain of the fibroblast growth factor receptor (FGFR2) has been studied by NMR and computational methods. Analysis of the heparin pentasaccharide in the free state and...

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Veröffentlicht in:	Chemistry : a European journal 2011-09, Vol.17 (40), p.11204-11209
Hauptverfasser:	Nieto, Lidia, Canales, Ángeles, Giménez-Gallego, Guillermo, Nieto, Pedro M., Jiménez-Barbero, Jesús
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry conformation analysis Fibroblasts Growth factors molecular dynamics molecular recognition NMR spectroscopy protein-carbohydrate interactions
Online-Zugang:	Volltext
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