A critical appraisal of one‐stage and chromogenic assays of factor VIII activity

Summary Accurate and precise potency determination by manufacturers of different types of factor VIII product (plasma‐derived and recombinant FVIII [rFVIII]) is vital to clinicians and patients using FVIII concentrates. A separate, but related, requirement is ascertaining the FVIII activity levels i...

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Veröffentlicht in:	Journal of thrombosis and haemostasis 2016-02, Vol.14 (2), p.248-261
Hauptverfasser:	Peyvandi, F., Oldenburg, J., Friedman, K. D.
Format:	Artikel
Sprache:	eng
Schlagworte:	activated partial thromboplastin time assay Biomarkers - blood Blood Coagulation - drug effects Blood Coagulation Tests Chromogenic Compounds Drug Monitoring - methods factor VIII Factor VIII - pharmacokinetics Factor VIII - standards Factor VIII - therapeutic use hemophilia A Hemophilia A - blood Hemophilia A - diagnosis Hemophilia A - drug therapy Hemostatics - standards Hemostatics - therapeutic use Humans Observer Variation Predictive Value of Tests Quality Control Reagent Kits, Diagnostic Reproducibility of Results
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