Physical activity and weight loss are independent predictors of improved insulin sensitivity following energy restriction
Objective The role of physical activity and the joint effect with sleep duration on insulin sensitivity (IS) during energy restriction followed by weight maintenance were determined. Methods One hundred and two subjects (28 males) (mean ± SD age: 40 ± 9 years; BMI: 31.9 ± 3.0 kg/m2) followed a very‐...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2016-02, Vol.24 (2), p.291-296 |
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| creator | Camps, Stefan G. J. A. Verhoef, Sanne P. M. Westerterp, Klaas R. |
| description | Objective
The role of physical activity and the joint effect with sleep duration on insulin sensitivity (IS) during energy restriction followed by weight maintenance were determined.
Methods
One hundred and two subjects (28 males) (mean ± SD age: 40 ± 9 years; BMI: 31.9 ± 3.0 kg/m2) followed a very‐low‐energy diet for 8 weeks, followed by a 44‐week period of weight maintenance. Body composition (three‐compartment model based on body weight, total body water, and body volume), physical activity (accelerometry), sleep (questionnaire, Epworth Sleepiness Scale), and fasting plasma insulin and glucose concentrations were assessed before the diet and at 8, 20, and 52 weeks after the start.
Results
Compared to baseline, IS was improved significantly after 8 weeks (P |
| doi_str_mv | 10.1002/oby.21325 |
| format | Article |
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The role of physical activity and the joint effect with sleep duration on insulin sensitivity (IS) during energy restriction followed by weight maintenance were determined.
Methods
One hundred and two subjects (28 males) (mean ± SD age: 40 ± 9 years; BMI: 31.9 ± 3.0 kg/m2) followed a very‐low‐energy diet for 8 weeks, followed by a 44‐week period of weight maintenance. Body composition (three‐compartment model based on body weight, total body water, and body volume), physical activity (accelerometry), sleep (questionnaire, Epworth Sleepiness Scale), and fasting plasma insulin and glucose concentrations were assessed before the diet and at 8, 20, and 52 weeks after the start.
Results
Compared to baseline, IS was improved significantly after 8 weeks (P < 0.001) and was higher after 20 weeks (P < 0.001) and 52 weeks (P < 0.05). After 8, 20, and 52 weeks, 23% (P < 0.01), 19% (P < 0.05), and 13% (P < 0.05), respectively, of the variance in IS improvement was explained by weight loss percentage and change in physical activity counts.
Conclusions
Maintaining daily physical activity during energy restriction is as important as weight loss itself in the improvement of IS; there was no additional effect of change in sleep duration. During weight maintenance, improved IS is maintained better if physical activity returns to baseline or higher.]]></description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.21325</identifier><identifier>PMID: 26813523</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Body Weight ; Caloric Restriction ; Diet, Reducing - methods ; Energy Metabolism - physiology ; Exercise ; Female ; Follow-Up Studies ; Glucose ; Humans ; Insulin ; Insulin Resistance - physiology ; Male ; Middle Aged ; Motor Activity - physiology ; Obesity ; Rodents ; Sleep - physiology ; Weight Loss</subject><ispartof>Obesity (Silver Spring, Md.), 2016-02, Vol.24 (2), p.291-296</ispartof><rights>2016 The Obesity Society</rights><rights>2016 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Feb 2016</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5245-5b099fba5f5a9cd78cafc6c0b50620267202181060ec7b15cc1c9ff5974771e63</citedby><cites>FETCH-LOGICAL-c5245-5b099fba5f5a9cd78cafc6c0b50620267202181060ec7b15cc1c9ff5974771e63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.21325$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.21325$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26813523$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Camps, Stefan G. J. A.</creatorcontrib><creatorcontrib>Verhoef, Sanne P. M.</creatorcontrib><creatorcontrib>Westerterp, Klaas R.</creatorcontrib><title>Physical activity and weight loss are independent predictors of improved insulin sensitivity following energy restriction</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description><![CDATA[Objective
The role of physical activity and the joint effect with sleep duration on insulin sensitivity (IS) during energy restriction followed by weight maintenance were determined.
Methods
One hundred and two subjects (28 males) (mean ± SD age: 40 ± 9 years; BMI: 31.9 ± 3.0 kg/m2) followed a very‐low‐energy diet for 8 weeks, followed by a 44‐week period of weight maintenance. Body composition (three‐compartment model based on body weight, total body water, and body volume), physical activity (accelerometry), sleep (questionnaire, Epworth Sleepiness Scale), and fasting plasma insulin and glucose concentrations were assessed before the diet and at 8, 20, and 52 weeks after the start.
Results
Compared to baseline, IS was improved significantly after 8 weeks (P < 0.001) and was higher after 20 weeks (P < 0.001) and 52 weeks (P < 0.05). After 8, 20, and 52 weeks, 23% (P < 0.01), 19% (P < 0.05), and 13% (P < 0.05), respectively, of the variance in IS improvement was explained by weight loss percentage and change in physical activity counts.
Conclusions
Maintaining daily physical activity during energy restriction is as important as weight loss itself in the improvement of IS; there was no additional effect of change in sleep duration. During weight maintenance, improved IS is maintained better if physical activity returns to baseline or higher.]]></description><subject>Adult</subject><subject>Body Weight</subject><subject>Caloric Restriction</subject><subject>Diet, Reducing - methods</subject><subject>Energy Metabolism - physiology</subject><subject>Exercise</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glucose</subject><subject>Humans</subject><subject>Insulin</subject><subject>Insulin Resistance - physiology</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor Activity - physiology</subject><subject>Obesity</subject><subject>Rodents</subject><subject>Sleep - physiology</subject><subject>Weight Loss</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kD1PwzAQhi0EoqUw8AeQJSaGtLYTO8kIFV9SpTKABFPkOHbrKrWDnbTKv8eQwsZyd8Pj984PAJcYTTFCZGbLfkpwTOgRGOM8RlEa5-_Hf3OGR-DM-w1CCUMUn4IRYRmOKYnHoH9Z914LXkMuWr3TbQ-5qeBe6tW6hbX1HnInoTaVbGQopoWNk5UWrXUeWgX1tnF2J6uA-K7WBnppvD5EKVvXdq_NCkoj3aqHTvrWhcfamnNwonjt5cWhT8Dbw_3r_ClaLB-f57eLSFCS0IiWKM9VyamiPBdVmgmuBBOopIgRRFgaCs4wYkiKtMRUCCxypWieJmmKJYsn4HrIDXd-dmF_sbGdM2FlgVOWZFkcpATqZqCEC392UhWN01vu-gKj4ltyESQXP5IDe3VI7MqtrP7IX6sBmA3AXtey_z-pWN59DJFfVtCJCQ</recordid><startdate>201602</startdate><enddate>201602</enddate><creator>Camps, Stefan G. J. A.</creator><creator>Verhoef, Sanne P. M.</creator><creator>Westerterp, Klaas R.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>201602</creationdate><title>Physical activity and weight loss are independent predictors of improved insulin sensitivity following energy restriction</title><author>Camps, Stefan G. J. A. ; Verhoef, Sanne P. M. ; Westerterp, Klaas R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5245-5b099fba5f5a9cd78cafc6c0b50620267202181060ec7b15cc1c9ff5974771e63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Body Weight</topic><topic>Caloric Restriction</topic><topic>Diet, Reducing - methods</topic><topic>Energy Metabolism - physiology</topic><topic>Exercise</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glucose</topic><topic>Humans</topic><topic>Insulin</topic><topic>Insulin Resistance - physiology</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor Activity - physiology</topic><topic>Obesity</topic><topic>Rodents</topic><topic>Sleep - physiology</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Camps, Stefan G. J. A.</creatorcontrib><creatorcontrib>Verhoef, Sanne P. M.</creatorcontrib><creatorcontrib>Westerterp, Klaas R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Camps, Stefan G. J. A.</au><au>Verhoef, Sanne P. M.</au><au>Westerterp, Klaas R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Physical activity and weight loss are independent predictors of improved insulin sensitivity following energy restriction</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2016-02</date><risdate>2016</risdate><volume>24</volume><issue>2</issue><spage>291</spage><epage>296</epage><pages>291-296</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract><![CDATA[Objective
The role of physical activity and the joint effect with sleep duration on insulin sensitivity (IS) during energy restriction followed by weight maintenance were determined.
Methods
One hundred and two subjects (28 males) (mean ± SD age: 40 ± 9 years; BMI: 31.9 ± 3.0 kg/m2) followed a very‐low‐energy diet for 8 weeks, followed by a 44‐week period of weight maintenance. Body composition (three‐compartment model based on body weight, total body water, and body volume), physical activity (accelerometry), sleep (questionnaire, Epworth Sleepiness Scale), and fasting plasma insulin and glucose concentrations were assessed before the diet and at 8, 20, and 52 weeks after the start.
Results
Compared to baseline, IS was improved significantly after 8 weeks (P < 0.001) and was higher after 20 weeks (P < 0.001) and 52 weeks (P < 0.05). After 8, 20, and 52 weeks, 23% (P < 0.01), 19% (P < 0.05), and 13% (P < 0.05), respectively, of the variance in IS improvement was explained by weight loss percentage and change in physical activity counts.
Conclusions
Maintaining daily physical activity during energy restriction is as important as weight loss itself in the improvement of IS; there was no additional effect of change in sleep duration. During weight maintenance, improved IS is maintained better if physical activity returns to baseline or higher.]]></abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26813523</pmid><doi>10.1002/oby.21325</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Body Weight Caloric Restriction Diet, Reducing - methods Energy Metabolism - physiology Exercise Female Follow-Up Studies Glucose Humans Insulin Insulin Resistance - physiology Male Middle Aged Motor Activity - physiology Obesity Rodents Sleep - physiology Weight Loss |
| title | Physical activity and weight loss are independent predictors of improved insulin sensitivity following energy restriction |
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