Clinical and microbiological effects of systemic azithromycin in adjunct to nonsurgical periodontal therapy in treatment of Aggregatibacter actinomycetemcomitans associated periodontitis: a randomized placebo-controlled clinical trial
Objective This study aimed to evaluate clinical and microbiological effects of systemic azithromycin (AZM) in adjunct to nonsurgical periodontal therapy (NSPT; or scaling root planing – SRP) in treatment of Aggregatibacter actinomycetemcomitans associated periodontitis (AAAP). Methods and materials...
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| Veröffentlicht in: | Journal of investigative and clinical dentistry 2016-02, Vol.7 (1), p.72-80 |
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| creator | Martande, Santosh S. Pradeep, Avani R. Singh, Sonender P. Kumari, Minal Naik, Savitha B. Suke, Deepak Kumar Singh, Priyanka |
| description | Objective
This study aimed to evaluate clinical and microbiological effects of systemic azithromycin (AZM) in adjunct to nonsurgical periodontal therapy (NSPT; or scaling root planing – SRP) in treatment of Aggregatibacter actinomycetemcomitans associated periodontitis (AAAP).
Methods and materials
Seventy individuals with moderate to severe periodontitis and subgingival detection of A. actinomycetemcomitans were randomly allocated to two groups. Thirty‐five individuals were allocated to full mouth SRP+AZM (500 mg oral delivery (OD) × 3 days) while 35 individuals were allocated to SRP+Placebo (OD × 3 days) group. The clinical variables evaluated were probing depth (PD), clinical attachment level (CAL), gingival index (GI), plaque index (PI), and percent bleeding on probing sites (%BOP), while microbiologic variables included percentage of subjects positive for A. actinomycetemcomitans at baseline, 3, 6, and 12 months.
Results
The AZM group showed statistically significant reduction in mean PD (2.91 ± 0.88 mm) as compared to placebo (1.51 ± 0.98 mm) (P |
| doi_str_mv | 10.1111/jicd.12115 |
| format | Article |
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This study aimed to evaluate clinical and microbiological effects of systemic azithromycin (AZM) in adjunct to nonsurgical periodontal therapy (NSPT; or scaling root planing – SRP) in treatment of Aggregatibacter actinomycetemcomitans associated periodontitis (AAAP).
Methods and materials
Seventy individuals with moderate to severe periodontitis and subgingival detection of A. actinomycetemcomitans were randomly allocated to two groups. Thirty‐five individuals were allocated to full mouth SRP+AZM (500 mg oral delivery (OD) × 3 days) while 35 individuals were allocated to SRP+Placebo (OD × 3 days) group. The clinical variables evaluated were probing depth (PD), clinical attachment level (CAL), gingival index (GI), plaque index (PI), and percent bleeding on probing sites (%BOP), while microbiologic variables included percentage of subjects positive for A. actinomycetemcomitans at baseline, 3, 6, and 12 months.
Results
The AZM group showed statistically significant reduction in mean PD (2.91 ± 0.88 mm) as compared to placebo (1.51 ± 0.98 mm) (P < 0.001), while CAL gain was significant in the AZM group (2.71 ± 1.15 mm) as compared to the placebo group (1.71 ± 1.29 mm) (P < 0.001). There was also a statistically significant reduction in the number of subjects positive for A. actinomycetemcomitans in the AZM group (P < 0.0001).
Conclusion
Azithromycin was found to significantly improve the clinical and microbiological parameters in AAAP individuals.</description><identifier>ISSN: 2041-1618</identifier><identifier>EISSN: 2041-1626</identifier><identifier>DOI: 10.1111/jicd.12115</identifier><identifier>PMID: 25044531</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Aggregatibacter actinomycetemcomitans ; Anti-Bacterial Agents - therapeutic use ; Azithromycin - therapeutic use ; Dental Scaling ; Follow-Up Studies ; Humans ; nonsurgical periodontal therapy ; Pasteurellaceae Infections - drug therapy ; Periodontal Attachment Loss - drug therapy ; Periodontal Index ; Periodontal Pocket - drug therapy ; Periodontitis - drug therapy ; Root Planing ; systemic antibiotics</subject><ispartof>Journal of investigative and clinical dentistry, 2016-02, Vol.7 (1), p.72-80</ispartof><rights>2014 Wiley Publishing Asia Pty Ltd</rights><rights>2014 Wiley Publishing Asia Pty Ltd.</rights><rights>Copyright © 2016 John Wiley & Sons Australia, Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3955-b7d3da1e1f70f3195947c68f474d6ee12fcf8abb9c6c345fb156cb96a150dad03</citedby><cites>FETCH-LOGICAL-c3955-b7d3da1e1f70f3195947c68f474d6ee12fcf8abb9c6c345fb156cb96a150dad03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fjicd.12115$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fjicd.12115$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27922,27923,45572,45573</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25044531$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Martande, Santosh S.</creatorcontrib><creatorcontrib>Pradeep, Avani R.</creatorcontrib><creatorcontrib>Singh, Sonender P.</creatorcontrib><creatorcontrib>Kumari, Minal</creatorcontrib><creatorcontrib>Naik, Savitha B.</creatorcontrib><creatorcontrib>Suke, Deepak Kumar</creatorcontrib><creatorcontrib>Singh, Priyanka</creatorcontrib><title>Clinical and microbiological effects of systemic azithromycin in adjunct to nonsurgical periodontal therapy in treatment of Aggregatibacter actinomycetemcomitans associated periodontitis: a randomized placebo-controlled clinical trial</title><title>Journal of investigative and clinical dentistry</title><addtitle>J Invest Clin Dent</addtitle><description>Objective
This study aimed to evaluate clinical and microbiological effects of systemic azithromycin (AZM) in adjunct to nonsurgical periodontal therapy (NSPT; or scaling root planing – SRP) in treatment of Aggregatibacter actinomycetemcomitans associated periodontitis (AAAP).
Methods and materials
Seventy individuals with moderate to severe periodontitis and subgingival detection of A. actinomycetemcomitans were randomly allocated to two groups. Thirty‐five individuals were allocated to full mouth SRP+AZM (500 mg oral delivery (OD) × 3 days) while 35 individuals were allocated to SRP+Placebo (OD × 3 days) group. The clinical variables evaluated were probing depth (PD), clinical attachment level (CAL), gingival index (GI), plaque index (PI), and percent bleeding on probing sites (%BOP), while microbiologic variables included percentage of subjects positive for A. actinomycetemcomitans at baseline, 3, 6, and 12 months.
Results
The AZM group showed statistically significant reduction in mean PD (2.91 ± 0.88 mm) as compared to placebo (1.51 ± 0.98 mm) (P < 0.001), while CAL gain was significant in the AZM group (2.71 ± 1.15 mm) as compared to the placebo group (1.71 ± 1.29 mm) (P < 0.001). There was also a statistically significant reduction in the number of subjects positive for A. actinomycetemcomitans in the AZM group (P < 0.0001).
Conclusion
Azithromycin was found to significantly improve the clinical and microbiological parameters in AAAP individuals.</description><subject>Aggregatibacter actinomycetemcomitans</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Azithromycin - therapeutic use</subject><subject>Dental Scaling</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>nonsurgical periodontal therapy</subject><subject>Pasteurellaceae Infections - drug therapy</subject><subject>Periodontal Attachment Loss - drug therapy</subject><subject>Periodontal Index</subject><subject>Periodontal Pocket - drug therapy</subject><subject>Periodontitis - drug therapy</subject><subject>Root Planing</subject><subject>systemic antibiotics</subject><issn>2041-1618</issn><issn>2041-1626</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9u1DAQxiMEolXphQdAlrghpcRJ7CTcyhaWoqpwKELiYk3s8dZLYm9tryB9ZJ4Cp9tdbows25r5zec_X5a9pMUZTfF2baQ6oyWl7El2XBY1zSkv-dPDnrZH2WkI6yJF1bact8-zo5IVdc0qepz9WQzGGgkDAavIaKR3vXGDWz3kUGuUMRCnSZhCxFQncG_irXfjJI0laYBab62MJDpinQ1bv2vdoDdOORvTPt6ih80009EjxBFtnDXPVyuPK4imBxnRkzQbOytjOkq60USwgUAIThqIqP6JmmjCOwLEp1sn7n6uDSCxd7lMZe-GIaXk_m3RGxheZM80DAFPH9eT7NvHDzeLT_nVl-Xl4vwql1XHWN43qlJAkeqm0BXtWFc3kre6bmrFEWmppW6h7zvJZVUz3VPGZd9xoKxQoIrqJHu90914d7fFEMXabb1NRwra8LJLn8-6RL3ZUenHQ_CoxcabEfwkaCFmZ8XsrHhwNsGvHiW3_YjqgO59TADdAb_MgNN_pMTny8XFXjTf9Zjk7O9DD_ifgjdVw8T366V4v7gufiwvvoqb6i9lo8Ye</recordid><startdate>201602</startdate><enddate>201602</enddate><creator>Martande, Santosh S.</creator><creator>Pradeep, Avani R.</creator><creator>Singh, Sonender P.</creator><creator>Kumari, Minal</creator><creator>Naik, Savitha B.</creator><creator>Suke, Deepak Kumar</creator><creator>Singh, Priyanka</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>201602</creationdate><title>Clinical and microbiological effects of systemic azithromycin in adjunct to nonsurgical periodontal therapy in treatment of Aggregatibacter actinomycetemcomitans associated periodontitis: a randomized placebo-controlled clinical trial</title><author>Martande, Santosh S. ; Pradeep, Avani R. ; Singh, Sonender P. ; Kumari, Minal ; Naik, Savitha B. ; Suke, Deepak Kumar ; Singh, Priyanka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3955-b7d3da1e1f70f3195947c68f474d6ee12fcf8abb9c6c345fb156cb96a150dad03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Aggregatibacter actinomycetemcomitans</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Azithromycin - therapeutic use</topic><topic>Dental Scaling</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>nonsurgical periodontal therapy</topic><topic>Pasteurellaceae Infections - drug therapy</topic><topic>Periodontal Attachment Loss - drug therapy</topic><topic>Periodontal Index</topic><topic>Periodontal Pocket - drug therapy</topic><topic>Periodontitis - drug therapy</topic><topic>Root Planing</topic><topic>systemic antibiotics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Martande, Santosh S.</creatorcontrib><creatorcontrib>Pradeep, Avani R.</creatorcontrib><creatorcontrib>Singh, Sonender P.</creatorcontrib><creatorcontrib>Kumari, Minal</creatorcontrib><creatorcontrib>Naik, Savitha B.</creatorcontrib><creatorcontrib>Suke, Deepak Kumar</creatorcontrib><creatorcontrib>Singh, Priyanka</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Journal of investigative and clinical dentistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Martande, Santosh S.</au><au>Pradeep, Avani R.</au><au>Singh, Sonender P.</au><au>Kumari, Minal</au><au>Naik, Savitha B.</au><au>Suke, Deepak Kumar</au><au>Singh, Priyanka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical and microbiological effects of systemic azithromycin in adjunct to nonsurgical periodontal therapy in treatment of Aggregatibacter actinomycetemcomitans associated periodontitis: a randomized placebo-controlled clinical trial</atitle><jtitle>Journal of investigative and clinical dentistry</jtitle><addtitle>J Invest Clin Dent</addtitle><date>2016-02</date><risdate>2016</risdate><volume>7</volume><issue>1</issue><spage>72</spage><epage>80</epage><pages>72-80</pages><issn>2041-1618</issn><eissn>2041-1626</eissn><abstract>Objective
This study aimed to evaluate clinical and microbiological effects of systemic azithromycin (AZM) in adjunct to nonsurgical periodontal therapy (NSPT; or scaling root planing – SRP) in treatment of Aggregatibacter actinomycetemcomitans associated periodontitis (AAAP).
Methods and materials
Seventy individuals with moderate to severe periodontitis and subgingival detection of A. actinomycetemcomitans were randomly allocated to two groups. Thirty‐five individuals were allocated to full mouth SRP+AZM (500 mg oral delivery (OD) × 3 days) while 35 individuals were allocated to SRP+Placebo (OD × 3 days) group. The clinical variables evaluated were probing depth (PD), clinical attachment level (CAL), gingival index (GI), plaque index (PI), and percent bleeding on probing sites (%BOP), while microbiologic variables included percentage of subjects positive for A. actinomycetemcomitans at baseline, 3, 6, and 12 months.
Results
The AZM group showed statistically significant reduction in mean PD (2.91 ± 0.88 mm) as compared to placebo (1.51 ± 0.98 mm) (P < 0.001), while CAL gain was significant in the AZM group (2.71 ± 1.15 mm) as compared to the placebo group (1.71 ± 1.29 mm) (P < 0.001). There was also a statistically significant reduction in the number of subjects positive for A. actinomycetemcomitans in the AZM group (P < 0.0001).
Conclusion
Azithromycin was found to significantly improve the clinical and microbiological parameters in AAAP individuals.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>25044531</pmid><doi>10.1111/jicd.12115</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 2041-1618 |
| ispartof | Journal of investigative and clinical dentistry, 2016-02, Vol.7 (1), p.72-80 |
| issn | 2041-1618 2041-1626 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aggregatibacter actinomycetemcomitans Anti-Bacterial Agents - therapeutic use Azithromycin - therapeutic use Dental Scaling Follow-Up Studies Humans nonsurgical periodontal therapy Pasteurellaceae Infections - drug therapy Periodontal Attachment Loss - drug therapy Periodontal Index Periodontal Pocket - drug therapy Periodontitis - drug therapy Root Planing systemic antibiotics |
| title | Clinical and microbiological effects of systemic azithromycin in adjunct to nonsurgical periodontal therapy in treatment of Aggregatibacter actinomycetemcomitans associated periodontitis: a randomized placebo-controlled clinical trial |
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