Stereotactic body radiation therapy for small primary or recurrent hepatocellular carcinoma in 132 Chinese patients
Aim To evaluate the efficacy of stereotactic body radiation therapy (SBRT) in small hepatocellular carcinoma (HCC) patients. Methods From March 2009 to April 2015, we treated 132 small HCC patients with SBRT. Eligibility criteria included longest tumor diameter ≤5.0 cm; Child‐Turcotte‐Pugh (CTP) Cla...
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| Veröffentlicht in: | Journal of surgical oncology 2016-02, Vol.113 (2), p.181-187 |
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| creator | Su, Ting-Shi Liang, Ping Lu, Huan-Zhen Liang, Jian Gao, Ying-Chuan Zhou, Ying Huang, Yong Tang, Min-Yang Liang, Jian-Ning |
| description | Aim
To evaluate the efficacy of stereotactic body radiation therapy (SBRT) in small hepatocellular carcinoma (HCC) patients.
Methods
From March 2009 to April 2015, we treated 132 small HCC patients with SBRT. Eligibility criteria included longest tumor diameter ≤5.0 cm; Child‐Turcotte‐Pugh (CTP) Class A or B; unfeasible, difficult or refusal to undergo other surgery or percutaneous ablative therapies; and tumor recurrence after other local treatment. The dose of 42–46 Gy in 3–5 fractions and 28–30 Gy in 1 fraction was prescribed.
Results
Of the treated patients, 114 were classified as CTP A and 18 as CTP B. Median tumor size was range 1.1–5.0 cm. The local control rate at 1 years was 90.9%. OS at 1, 3, and 5 years was 94.1%, 73.5%, and 64.3%, respectively. PFS at 1, 3, and 5 years was 82.7%, 58.3%, and 36.4%, respectively. Hepatic toxicity grade ≥3 was observed in 11 patients. Multivariate analysis revealed that CTP B was associated with worse OS (P |
| doi_str_mv | 10.1002/jso.24128 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1758983888</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3929300551</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5278-5d484658121287d294c9553d4c59621d27ca9ddc07606a35499fb8f6057582c83</originalsourceid><addsrcrecordid>eNp10E1PIyEYB3Bi3Ky1uwe_gCHx5GEsMMPb0TTW16wHd9cjocCk1OlQgYn224u2evNEAr_nT54_AEcYnWGEyGSZwhlpMBF7YISRZJVEUuyDUXkjVcMlOgCHKS0RQlKy5ic4IIxLSRgagfSQXXQha5O9gfNgNzBq63X2oYd54aJeb2AbIkwr3XVwHf1Kxw0sF9GZIUbXZ7hwa52DcV03dDpCo6PxfVhp6HuIawKnC9-75GBRvvj0C_xodZfc7905Bv9mF3-nV9Xd_eX19PyuMpRwUVHbiIZRgUnZjFsiGyMprW1jqGQEW8KNltYaxBliuqaNlO1ctAxRTgUxoh6Dk23uOobnwaWslmGIfflS4UKkqIV4V6dbZWJIKbpW7ZZUGKn3elWpV33UW-zxLnGYr5z9kp99FjDZghffuc33Serm4f4zstpO-JTd69eEjk-K8ZpT9fjnUvHH-v_tzYwrVr8BNUCTRg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1758983888</pqid></control><display><type>article</type><title>Stereotactic body radiation therapy for small primary or recurrent hepatocellular carcinoma in 132 Chinese patients</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Su, Ting-Shi ; Liang, Ping ; Lu, Huan-Zhen ; Liang, Jian ; Gao, Ying-Chuan ; Zhou, Ying ; Huang, Yong ; Tang, Min-Yang ; Liang, Jian-Ning</creator><creatorcontrib>Su, Ting-Shi ; Liang, Ping ; Lu, Huan-Zhen ; Liang, Jian ; Gao, Ying-Chuan ; Zhou, Ying ; Huang, Yong ; Tang, Min-Yang ; Liang, Jian-Ning</creatorcontrib><description>Aim
To evaluate the efficacy of stereotactic body radiation therapy (SBRT) in small hepatocellular carcinoma (HCC) patients.
Methods
From March 2009 to April 2015, we treated 132 small HCC patients with SBRT. Eligibility criteria included longest tumor diameter ≤5.0 cm; Child‐Turcotte‐Pugh (CTP) Class A or B; unfeasible, difficult or refusal to undergo other surgery or percutaneous ablative therapies; and tumor recurrence after other local treatment. The dose of 42–46 Gy in 3–5 fractions and 28–30 Gy in 1 fraction was prescribed.
Results
Of the treated patients, 114 were classified as CTP A and 18 as CTP B. Median tumor size was range 1.1–5.0 cm. The local control rate at 1 years was 90.9%. OS at 1, 3, and 5 years was 94.1%, 73.5%, and 64.3%, respectively. PFS at 1, 3, and 5 years was 82.7%, 58.3%, and 36.4%, respectively. Hepatic toxicity grade ≥3 was observed in 11 patients. Multivariate analysis revealed that CTP B was associated with worse OS (P < 0.001) and multiple nodules were associated with worse PFS (P = 0.001).
Conclusions
SBRT is a promising alternative treatment for patients with primary or recurrent small HCC who are unsuitable for surgical resection or local ablative therapy. J. Surg. Oncol. 2016;113:181–187. © 2015 Wiley Periodicals, Inc.</description><identifier>ISSN: 0022-4790</identifier><identifier>EISSN: 1096-9098</identifier><identifier>DOI: 10.1002/jso.24128</identifier><identifier>PMID: 26799260</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Asian Continental Ancestry Group - statistics & numerical data ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; China ; CyberKnife ; Female ; Follow-Up Studies ; hepatocellular carcinoma ; Humans ; Kaplan-Meier Estimate ; Liver cancer ; Liver cirrhosis ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Male ; Middle Aged ; Multivariate analysis ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - surgery ; Predictive Value of Tests ; Prognosis ; Radiation therapy ; Radiosurgery ; radiotherapy ; Radiotherapy Dosage ; small HCC ; stereotactic body radiation therapy ; Treatment Outcome</subject><ispartof>Journal of surgical oncology, 2016-02, Vol.113 (2), p.181-187</ispartof><rights>2015 Wiley Periodicals, Inc.</rights><rights>2016 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5278-5d484658121287d294c9553d4c59621d27ca9ddc07606a35499fb8f6057582c83</citedby><cites>FETCH-LOGICAL-c5278-5d484658121287d294c9553d4c59621d27ca9ddc07606a35499fb8f6057582c83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjso.24128$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjso.24128$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26799260$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Su, Ting-Shi</creatorcontrib><creatorcontrib>Liang, Ping</creatorcontrib><creatorcontrib>Lu, Huan-Zhen</creatorcontrib><creatorcontrib>Liang, Jian</creatorcontrib><creatorcontrib>Gao, Ying-Chuan</creatorcontrib><creatorcontrib>Zhou, Ying</creatorcontrib><creatorcontrib>Huang, Yong</creatorcontrib><creatorcontrib>Tang, Min-Yang</creatorcontrib><creatorcontrib>Liang, Jian-Ning</creatorcontrib><title>Stereotactic body radiation therapy for small primary or recurrent hepatocellular carcinoma in 132 Chinese patients</title><title>Journal of surgical oncology</title><addtitle>J. Surg. Oncol</addtitle><description>Aim
To evaluate the efficacy of stereotactic body radiation therapy (SBRT) in small hepatocellular carcinoma (HCC) patients.
Methods
From March 2009 to April 2015, we treated 132 small HCC patients with SBRT. Eligibility criteria included longest tumor diameter ≤5.0 cm; Child‐Turcotte‐Pugh (CTP) Class A or B; unfeasible, difficult or refusal to undergo other surgery or percutaneous ablative therapies; and tumor recurrence after other local treatment. The dose of 42–46 Gy in 3–5 fractions and 28–30 Gy in 1 fraction was prescribed.
Results
Of the treated patients, 114 were classified as CTP A and 18 as CTP B. Median tumor size was range 1.1–5.0 cm. The local control rate at 1 years was 90.9%. OS at 1, 3, and 5 years was 94.1%, 73.5%, and 64.3%, respectively. PFS at 1, 3, and 5 years was 82.7%, 58.3%, and 36.4%, respectively. Hepatic toxicity grade ≥3 was observed in 11 patients. Multivariate analysis revealed that CTP B was associated with worse OS (P < 0.001) and multiple nodules were associated with worse PFS (P = 0.001).
Conclusions
SBRT is a promising alternative treatment for patients with primary or recurrent small HCC who are unsuitable for surgical resection or local ablative therapy. J. Surg. Oncol. 2016;113:181–187. © 2015 Wiley Periodicals, Inc.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Asian Continental Ancestry Group - statistics & numerical data</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>China</subject><subject>CyberKnife</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>hepatocellular carcinoma</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Multivariate analysis</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Predictive Value of Tests</subject><subject>Prognosis</subject><subject>Radiation therapy</subject><subject>Radiosurgery</subject><subject>radiotherapy</subject><subject>Radiotherapy Dosage</subject><subject>small HCC</subject><subject>stereotactic body radiation therapy</subject><subject>Treatment Outcome</subject><issn>0022-4790</issn><issn>1096-9098</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10E1PIyEYB3Bi3Ky1uwe_gCHx5GEsMMPb0TTW16wHd9cjocCk1OlQgYn224u2evNEAr_nT54_AEcYnWGEyGSZwhlpMBF7YISRZJVEUuyDUXkjVcMlOgCHKS0RQlKy5ic4IIxLSRgagfSQXXQha5O9gfNgNzBq63X2oYd54aJeb2AbIkwr3XVwHf1Kxw0sF9GZIUbXZ7hwa52DcV03dDpCo6PxfVhp6HuIawKnC9-75GBRvvj0C_xodZfc7905Bv9mF3-nV9Xd_eX19PyuMpRwUVHbiIZRgUnZjFsiGyMprW1jqGQEW8KNltYaxBliuqaNlO1ctAxRTgUxoh6Dk23uOobnwaWslmGIfflS4UKkqIV4V6dbZWJIKbpW7ZZUGKn3elWpV33UW-zxLnGYr5z9kp99FjDZghffuc33Serm4f4zstpO-JTd69eEjk-K8ZpT9fjnUvHH-v_tzYwrVr8BNUCTRg</recordid><startdate>20160201</startdate><enddate>20160201</enddate><creator>Su, Ting-Shi</creator><creator>Liang, Ping</creator><creator>Lu, Huan-Zhen</creator><creator>Liang, Jian</creator><creator>Gao, Ying-Chuan</creator><creator>Zhou, Ying</creator><creator>Huang, Yong</creator><creator>Tang, Min-Yang</creator><creator>Liang, Jian-Ning</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope></search><sort><creationdate>20160201</creationdate><title>Stereotactic body radiation therapy for small primary or recurrent hepatocellular carcinoma in 132 Chinese patients</title><author>Su, Ting-Shi ; Liang, Ping ; Lu, Huan-Zhen ; Liang, Jian ; Gao, Ying-Chuan ; Zhou, Ying ; Huang, Yong ; Tang, Min-Yang ; Liang, Jian-Ning</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5278-5d484658121287d294c9553d4c59621d27ca9ddc07606a35499fb8f6057582c83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Asian Continental Ancestry Group - statistics & numerical data</topic><topic>Carcinoma, Hepatocellular - pathology</topic><topic>Carcinoma, Hepatocellular - surgery</topic><topic>China</topic><topic>CyberKnife</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>hepatocellular carcinoma</topic><topic>Humans</topic><topic>Kaplan-Meier Estimate</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver Neoplasms - pathology</topic><topic>Liver Neoplasms - surgery</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Multivariate analysis</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Predictive Value of Tests</topic><topic>Prognosis</topic><topic>Radiation therapy</topic><topic>Radiosurgery</topic><topic>radiotherapy</topic><topic>Radiotherapy Dosage</topic><topic>small HCC</topic><topic>stereotactic body radiation therapy</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Su, Ting-Shi</creatorcontrib><creatorcontrib>Liang, Ping</creatorcontrib><creatorcontrib>Lu, Huan-Zhen</creatorcontrib><creatorcontrib>Liang, Jian</creatorcontrib><creatorcontrib>Gao, Ying-Chuan</creatorcontrib><creatorcontrib>Zhou, Ying</creatorcontrib><creatorcontrib>Huang, Yong</creatorcontrib><creatorcontrib>Tang, Min-Yang</creatorcontrib><creatorcontrib>Liang, Jian-Ning</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>Journal of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Su, Ting-Shi</au><au>Liang, Ping</au><au>Lu, Huan-Zhen</au><au>Liang, Jian</au><au>Gao, Ying-Chuan</au><au>Zhou, Ying</au><au>Huang, Yong</au><au>Tang, Min-Yang</au><au>Liang, Jian-Ning</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Stereotactic body radiation therapy for small primary or recurrent hepatocellular carcinoma in 132 Chinese patients</atitle><jtitle>Journal of surgical oncology</jtitle><addtitle>J. Surg. Oncol</addtitle><date>2016-02-01</date><risdate>2016</risdate><volume>113</volume><issue>2</issue><spage>181</spage><epage>187</epage><pages>181-187</pages><issn>0022-4790</issn><eissn>1096-9098</eissn><abstract>Aim
To evaluate the efficacy of stereotactic body radiation therapy (SBRT) in small hepatocellular carcinoma (HCC) patients.
Methods
From March 2009 to April 2015, we treated 132 small HCC patients with SBRT. Eligibility criteria included longest tumor diameter ≤5.0 cm; Child‐Turcotte‐Pugh (CTP) Class A or B; unfeasible, difficult or refusal to undergo other surgery or percutaneous ablative therapies; and tumor recurrence after other local treatment. The dose of 42–46 Gy in 3–5 fractions and 28–30 Gy in 1 fraction was prescribed.
Results
Of the treated patients, 114 were classified as CTP A and 18 as CTP B. Median tumor size was range 1.1–5.0 cm. The local control rate at 1 years was 90.9%. OS at 1, 3, and 5 years was 94.1%, 73.5%, and 64.3%, respectively. PFS at 1, 3, and 5 years was 82.7%, 58.3%, and 36.4%, respectively. Hepatic toxicity grade ≥3 was observed in 11 patients. Multivariate analysis revealed that CTP B was associated with worse OS (P < 0.001) and multiple nodules were associated with worse PFS (P = 0.001).
Conclusions
SBRT is a promising alternative treatment for patients with primary or recurrent small HCC who are unsuitable for surgical resection or local ablative therapy. J. Surg. Oncol. 2016;113:181–187. © 2015 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>26799260</pmid><doi>10.1002/jso.24128</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Asian Continental Ancestry Group - statistics & numerical data Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery China CyberKnife Female Follow-Up Studies hepatocellular carcinoma Humans Kaplan-Meier Estimate Liver cancer Liver cirrhosis Liver Neoplasms - pathology Liver Neoplasms - surgery Male Middle Aged Multivariate analysis Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery Predictive Value of Tests Prognosis Radiation therapy Radiosurgery radiotherapy Radiotherapy Dosage small HCC stereotactic body radiation therapy Treatment Outcome |
| title | Stereotactic body radiation therapy for small primary or recurrent hepatocellular carcinoma in 132 Chinese patients |
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