Decreased expression of autophagy protein LC3 and stemness (CD44+/CD24−/low) indicate poor prognosis in triple-negative breast cancer

Summary This study evaluated the prognostic value of expression of autophagy protein light chain 3 (LC3) and the prognostic value of coexpression of LC3 and stemness markers CD44+/CD24−/low in triple-negative breast cancer (TNBC). LC3 and LC3/CD44+/CD24−/low immunophenotypes in tumor tissues were ev...

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Veröffentlicht in:	Human pathology 2016-02, Vol.48, p.48-55
Hauptverfasser:	Chang, Shu-Jyuan, BS, Ou-Yang, Fu, MD, Tu, Hung-Pin, PhD, Lin, Chih-Hung, MD, Huang, Shu-Hung, MD, Kostoro, Joanna, BS, MS, Hou, Ming-Feng, MD, Chai, Chee-Yin, MD, PhD, Kwan, Aij-Lie, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Antigens Autophagy Autophagy - physiology Breast cancer Cancer stem cell Cancer therapies CD44+/CD24−/low Chemotherapy Confidence intervals Female Humans Immunohistochemistry Kaplan-Meier Estimate Light chain 3 Medical prognosis Metastasis Microtubule-Associated Proteins - biosynthesis Middle Aged Mortality Neoplastic Stem Cells - pathology Pathology Phenotype Prognosis Proportional Hazards Models Proteins Studies Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - mortality Triple Negative Breast Neoplasms - pathology Triple-negative breast cancer Tumors
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