Current perspectives toward the identification of key players in gastric cancer microRNA dysregulation
Acquired genetic and epigenetic alterations in normal cells give rise to transformed cells, which lead to tumor development. Elucidation of the precise mechanisms underlying primary and metastatic tumor formation is required. MicroRNAs (miRNAs) are small noncoding RNAs that play a major role in post...
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| Veröffentlicht in: | International journal of cancer 2016-03, Vol.138 (6), p.1337-1349 |
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| container_title | International journal of cancer |
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| creator | Ishimoto, Takatsugu Baba, Hideo Izumi, Daisuke Sugihara, Hidetaka Kurashige, Junji Iwatsuki, Masaaki Tan, Patrick |
| description | Acquired genetic and epigenetic alterations in normal cells give rise to transformed cells, which lead to tumor development. Elucidation of the precise mechanisms underlying primary and metastatic tumor formation is required. MicroRNAs (miRNAs) are small noncoding RNAs that play a major role in post‐transcriptional gene regulation during various biological processes. Accumulating evidence suggests that dysregulation of miRNAs is intimately involved in the carcinogenesis, progression and metastasis of many cancers, including gastric cancers (GCs), while the alteration of certain miRNAs provides biomarkers to detect early GCs. This review summarizes the most recent findings into the mechanisms of miRNA‐mediated regulation of GCs, which will support the development of diagnostic biomarkers and novel therapeutic strategies. |
| doi_str_mv | 10.1002/ijc.29627 |
| format | Article |
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Elucidation of the precise mechanisms underlying primary and metastatic tumor formation is required. MicroRNAs (miRNAs) are small noncoding RNAs that play a major role in post‐transcriptional gene regulation during various biological processes. Accumulating evidence suggests that dysregulation of miRNAs is intimately involved in the carcinogenesis, progression and metastasis of many cancers, including gastric cancers (GCs), while the alteration of certain miRNAs provides biomarkers to detect early GCs. 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Elucidation of the precise mechanisms underlying primary and metastatic tumor formation is required. MicroRNAs (miRNAs) are small noncoding RNAs that play a major role in post‐transcriptional gene regulation during various biological processes. Accumulating evidence suggests that dysregulation of miRNAs is intimately involved in the carcinogenesis, progression and metastasis of many cancers, including gastric cancers (GCs), while the alteration of certain miRNAs provides biomarkers to detect early GCs. This review summarizes the most recent findings into the mechanisms of miRNA‐mediated regulation of GCs, which will support the development of diagnostic biomarkers and novel therapeutic strategies.</description><subject>Animals</subject><subject>Biomarkers</subject><subject>Biomarkers, Tumor</subject><subject>Cancer</subject><subject>cancer biomarker</subject><subject>Cell Movement - genetics</subject><subject>Cell Transformation, Neoplastic - genetics</subject><subject>Disease Progression</subject><subject>Drug Resistance, Neoplasm - drug effects</subject><subject>gastric cancer</subject><subject>Gene Expression Regulation, Neoplastic</subject><subject>H. pylori</subject><subject>Host-Pathogen Interactions - genetics</subject><subject>Humans</subject><subject>Medical research</subject><subject>microRNA</subject><subject>MicroRNAs - blood</subject><subject>MicroRNAs - genetics</subject><subject>Neoplasm Invasiveness</subject><subject>Neoplasm Metastasis</subject><subject>Neovascularization, Pathologic - genetics</subject><subject>Prognosis</subject><subject>Stomach Neoplasms - diagnosis</subject><subject>Stomach Neoplasms - drug therapy</subject><subject>Stomach Neoplasms - genetics</subject><subject>Stomach Neoplasms - microbiology</subject><subject>Stomach Neoplasms - mortality</subject><subject>therapeutic target</subject><issn>0020-7136</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kF1LwzAUhoMobk4v_AMS8LpbkjbNejmGH5OhIHod0uR0pnZtTVpH_71xm16dA-_zngMPQteUTCkhbGZLPWVZysQJGlOSiYgwyk_ROGQkEjROR-jC-5IQSjlJztGIpSQJIBujYtk7B3WHW3C-Bd3Zb_C4a3bKGdx9ALYmpLawWnW2qXFT4E8YcFupIRSwrfFG-c5ZjbWqNTi8tdo1r88LbAbvYNNX-94lOitU5eHqOCfo_f7ubfkYrV8eVsvFOioTTkQEVACkXOlCpbkx85SSvCCGGpgnOU-ForFKdZELnhhOaEwNywMUJwWNWQ4qnqDbw93WNV89-E6WTe_q8FJSwXnGOMuyQN0cqT7fgpGts1vlBvmnJQCzA7CzFQz_OSXy17cMvuXet1w9LfdL_AN7Z3Oz</recordid><startdate>20160315</startdate><enddate>20160315</enddate><creator>Ishimoto, Takatsugu</creator><creator>Baba, Hideo</creator><creator>Izumi, Daisuke</creator><creator>Sugihara, Hidetaka</creator><creator>Kurashige, Junji</creator><creator>Iwatsuki, Masaaki</creator><creator>Tan, Patrick</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope></search><sort><creationdate>20160315</creationdate><title>Current perspectives toward the identification of key players in gastric cancer microRNA dysregulation</title><author>Ishimoto, Takatsugu ; Baba, Hideo ; Izumi, Daisuke ; Sugihara, Hidetaka ; Kurashige, Junji ; Iwatsuki, Masaaki ; Tan, Patrick</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-j4507-e17ee65acfa6bdd8610bf0d1de84b567a13a6cfb754d50131d2b86134f132bea3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Animals</topic><topic>Biomarkers</topic><topic>Biomarkers, Tumor</topic><topic>Cancer</topic><topic>cancer biomarker</topic><topic>Cell Movement - genetics</topic><topic>Cell Transformation, Neoplastic - genetics</topic><topic>Disease Progression</topic><topic>Drug Resistance, Neoplasm - drug effects</topic><topic>gastric cancer</topic><topic>Gene Expression Regulation, Neoplastic</topic><topic>H. pylori</topic><topic>Host-Pathogen Interactions - genetics</topic><topic>Humans</topic><topic>Medical research</topic><topic>microRNA</topic><topic>MicroRNAs - blood</topic><topic>MicroRNAs - genetics</topic><topic>Neoplasm Invasiveness</topic><topic>Neoplasm Metastasis</topic><topic>Neovascularization, Pathologic - genetics</topic><topic>Prognosis</topic><topic>Stomach Neoplasms - diagnosis</topic><topic>Stomach Neoplasms - drug therapy</topic><topic>Stomach Neoplasms - genetics</topic><topic>Stomach Neoplasms - microbiology</topic><topic>Stomach Neoplasms - mortality</topic><topic>therapeutic target</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ishimoto, Takatsugu</creatorcontrib><creatorcontrib>Baba, Hideo</creatorcontrib><creatorcontrib>Izumi, Daisuke</creatorcontrib><creatorcontrib>Sugihara, Hidetaka</creatorcontrib><creatorcontrib>Kurashige, Junji</creatorcontrib><creatorcontrib>Iwatsuki, Masaaki</creatorcontrib><creatorcontrib>Tan, Patrick</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ishimoto, Takatsugu</au><au>Baba, Hideo</au><au>Izumi, Daisuke</au><au>Sugihara, Hidetaka</au><au>Kurashige, Junji</au><au>Iwatsuki, Masaaki</au><au>Tan, Patrick</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Current perspectives toward the identification of key players in gastric cancer microRNA dysregulation</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2016-03-15</date><risdate>2016</risdate><volume>138</volume><issue>6</issue><spage>1337</spage><epage>1349</epage><pages>1337-1349</pages><issn>0020-7136</issn><eissn>1097-0215</eissn><abstract>Acquired genetic and epigenetic alterations in normal cells give rise to transformed cells, which lead to tumor development. 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Biomarkers Biomarkers, Tumor Cancer cancer biomarker Cell Movement - genetics Cell Transformation, Neoplastic - genetics Disease Progression Drug Resistance, Neoplasm - drug effects gastric cancer Gene Expression Regulation, Neoplastic H. pylori Host-Pathogen Interactions - genetics Humans Medical research microRNA MicroRNAs - blood MicroRNAs - genetics Neoplasm Invasiveness Neoplasm Metastasis Neovascularization, Pathologic - genetics Prognosis Stomach Neoplasms - diagnosis Stomach Neoplasms - drug therapy Stomach Neoplasms - genetics Stomach Neoplasms - microbiology Stomach Neoplasms - mortality therapeutic target |
| title | Current perspectives toward the identification of key players in gastric cancer microRNA dysregulation |
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