Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-[Beta] plaques

Although the clustering of GFAP immunopositive astrocytes around amyloid-... plaques in Alzheimer's disease has led to the widespread assumption that plaques attract astrocytes, recent studies suggest that astrocytes stay put in injury. Here we reexamine astrocyte migration to plaques, using qu...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-12, Vol.112 (51), p.15556
Hauptverfasser:	Galea, Elena, Morrison, Will, Hudry, Eloise, Arbel-Ornath, Michal, Bacskai, Brian J, Gómez-Isla, Teresa, Stanley, H Eugene, Hyman, Bradley T
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Cells Confined spaces Genotype & phenotype Microscopy Rodents Spatial analysis Topology
Online-Zugang:	Volltext
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