Discovery of Potent Antiproliferative Agents Targeting EGFR Tyrosine Kinase Based on the Pyrido[3',2'

A series of pyridothieno[3,2-d]pyrimidin-4-amines was designed and synthesized as congeners to the classical 4-anilinoquinazolines as ATP-competitive epidermal growth factor receptor (EGFR) inhibitors. Compound 5a exhibited the most potent and selective inhibitory activity against EGFR with an IC50...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2015-12, Vol.63 (12), p.1015
Hauptverfasser:	Mohamed Abdel Aziz, Yasmine, Mokhtar Said, Mohamed, Ahmed El Shihawy, Hosam, Fathy Tolba, Mai, Abouzid Mohamed Abouzid, Khaled
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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