Cystine accumulation attenuates insulin release from the pancreatic [beta]-cell due to elevated oxidative stress and decreased ATP levels

Key points In cystinosis, a lysosomal storage disorder, an altered redox state has been suggested as contributing to cellular dysfunction. Ctns gene knockdown in a pancreatic [beta]-cell line caused increased cystine levels. Attenuated nutrient stimulated insulin secretion was observed after Ctns kn...

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Veröffentlicht in:	The Journal of physiology 2015-12, Vol.593 (23), p.5167
Hauptverfasser:	McEvoy, Bernadette, Sumayao, Rodolfo, Slattery, Craig, McMorrow, Tara, Newsholme, Philip
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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