Diagnostic and Prognostic Utility of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Cardiovascular Diseases - Review
NGAL (neutrophil gelatinase-associated lipocalin) is an acute phase protein, participating in antibacterial immunity. NGAL forms a complex with metalloproteinase 9 (MMP-9), thereby increasing its activity and preventing its degradation. NGAL is freely filtered through the glomerular membrane and rea...
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| Veröffentlicht in: | Kidney & blood pressure research 2014-01, Vol.39 (6), p.623-629 |
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| creator | Helanova, Katerina Spinar, Jindrich Parenica, Jiri |
| description | NGAL (neutrophil gelatinase-associated lipocalin) is an acute phase protein, participating in antibacterial immunity. NGAL forms a complex with metalloproteinase 9 (MMP-9), thereby increasing its activity and preventing its degradation. NGAL is freely filtered through the glomerular membrane and reabsorbed by endocytosis in the proximal tubule. NGAL detected in urine is produced mainly in the distal nephron. Elevated serum and urine NGAL allows diagnosis of acute kidney injury approximately 24 hours earlier than plasma creatinine concentration. Increased levels of NGAL were detected in patients with acute myocardial infarction, heart failure or stroke and were demonstrated to be strong predictors of adverse prognosis. |
| doi_str_mv | 10.1159/000368474 |
| format | Article |
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NGAL forms a complex with metalloproteinase 9 (MMP-9), thereby increasing its activity and preventing its degradation. NGAL is freely filtered through the glomerular membrane and reabsorbed by endocytosis in the proximal tubule. NGAL detected in urine is produced mainly in the distal nephron. Elevated serum and urine NGAL allows diagnosis of acute kidney injury approximately 24 hours earlier than plasma creatinine concentration. Increased levels of NGAL were detected in patients with acute myocardial infarction, heart failure or stroke and were demonstrated to be strong predictors of adverse prognosis.</description><subject>Acute-Phase Proteins - physiology</subject><subject>AKI</subject><subject>Biomarker</subject><subject>Biomarkers - blood</subject><subject>Cardiovascular disease</subject><subject>Cardiovascular Diseases - blood</subject><subject>Cardiovascular Diseases - diagnosis</subject><subject>Diagnosis</subject><subject>Humans</subject><subject>Lipocalin-2</subject><subject>Lipocalins - blood</subject><subject>Lipocalins - physiology</subject><subject>NGAL</subject><subject>Prognosis</subject><subject>Proto-Oncogene Proteins - blood</subject><subject>Proto-Oncogene Proteins - physiology</subject><subject>Review</subject><issn>1420-4096</issn><issn>1423-0143</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>M--</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DOA</sourceid><recordid>eNpt0ctu1DAUBuAIgWgpLNgjZKmbdhHwNXGWwxSGilGpKrq2HOd46iETBztp1TfoY9dM2iwQK98-__LxybL3BH8iRFSfMcaskLzkL7JDwinLMeHs5X6Oc46r4iB7E-M2MYExfZ0dUCEYoQwfZg9nTm86HwdnkO4adBn88_J6cK0b7pG36ALGIfj-xrVoBa0eXKcj5IsYvXF6gAatXe-Nbl2HTi5Wi_UpSrPL5KAbIrpzww1a6tA4f6ujGVsd0JmLkDIiytEV3Dq4e5u9srqN8O5pPMquv339tfyer3-uzpeLdW54wYa8IpZSQYmVlBlZlJYUlREarKHaWq5FU9RlWVjOmITaUmnrhhAwHISARhh2lJ1PuY3XW9UHt9PhXnnt1H7Dh43SIZXfgpI1p3X6Qwma81JCRaW0TFR1bS1pDEtZJ1NWH_yfEeKgdi4aaFvdgR-jIgUXZcmZKBM9_odu_Ri6VKkiJZM4lbFXp5MywccYwM4PJFj9bbWaW53sx6fEsd5BM8vn3ibwYQK_ddhAmMF8__i_xz--XE1C9Y1lj_uLuJc</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Helanova, Katerina</creator><creator>Spinar, Jindrich</creator><creator>Parenica, Jiri</creator><general>S. 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| subjects | Acute-Phase Proteins - physiology AKI Biomarker Biomarkers - blood Cardiovascular disease Cardiovascular Diseases - blood Cardiovascular Diseases - diagnosis Diagnosis Humans Lipocalin-2 Lipocalins - blood Lipocalins - physiology NGAL Prognosis Proto-Oncogene Proteins - blood Proto-Oncogene Proteins - physiology Review |
| title | Diagnostic and Prognostic Utility of Neutrophil Gelatinase-Associated Lipocalin (NGAL) in Patients with Cardiovascular Diseases - Review |
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