Severe obstructive sleep apnea increases left atrial volume independently of left ventricular diastolic impairment
Purpose Severe obstructive sleep apnea (OSA) directly impairs left ventricular (LV) diastolic function. Left atrial volume index (LAVI), an independent predictor of future cardiovascular events, is also related to OSA severity. This study aimed to assess whether OSA is associated with an increase in...
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| Veröffentlicht in: | Sleep & breathing 2015-12, Vol.19 (4), p.1249-1255 |
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| creator | Imai, Yasuko Tanaka, Nobuhiro Usui, Yasuhiro Takahashi, Nori Kurohane, Saiko Takei, Yasuyoshi Takata, Yoshifumi Yamashina, Akira |
| description | Purpose
Severe obstructive sleep apnea (OSA) directly impairs left ventricular (LV) diastolic function. Left atrial volume index (LAVI), an independent predictor of future cardiovascular events, is also related to OSA severity. This study aimed to assess whether OSA is associated with an increase in LAVI independently of LV diastolic function.
Methods
Two hundred six OSA patients (apnea hypopnea index, AHI ≥ 5/h) without cardiac disease, hypertension, and diabetes were enrolled. They underwent overnight fully attended polysomnography and 2-dimensional echocardiography in order to estimate LA volumes and LV diastolic function which was assessed by the ratio of transmitral early diastolic flow velocity to late diastolic flow velocity (E/A), deceleration time, and mitral annular velocity (e′) which was derived from tissue Doppler imaging. Patients were divided into two groups based on AHI, namely, group M (5 ≤ AHI |
| doi_str_mv | 10.1007/s11325-015-1153-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1737143113</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3879204291</sourcerecordid><originalsourceid>FETCH-LOGICAL-c409t-3f3cd33853d71cb0f61256108499ee966fb09c674008459fb131be7b0c2b22643</originalsourceid><addsrcrecordid>eNp1kE1LxDAQhoMo7rr6A7xIwHM1kzTN5ijiFyx4UM8hTacS6ZdJu-C_N9pVvHiZzOR95x14CDkFdgGMqcsIILjMGMgMQIpM7ZElSM4zUEzvf_cs0xL4ghzF-MYY5GsNh2TBpVJrnaslCU-4xYC0L-MYJjf6LdLYIA7UDh1a6jsX0EaMtMF6pHYM3jZ02zdTi0mscMBUurH5oH09e7ZpDN5NjQ208jaOfeMd9e1gfWiTdkwOattEPNm9K_Jye_N8fZ9tHu8erq82mcuZHjNRC1cJsZaiUuBKVhfAZQFsnWuNqIuiLpl2hcpZ-pK6LkFAiapkjpecF7lYkfM5dwj9-4RxNG_9FLp00oASCnKR8CUXzC4X-hgD1mYIvrXhwwAzX5TNTNkkyuaLslFp52yXPJUtVr8bP1iTgc-GmKTuFcOf0_-mfgKJN4jy</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1737143113</pqid></control><display><type>article</type><title>Severe obstructive sleep apnea increases left atrial volume independently of left ventricular diastolic impairment</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Imai, Yasuko ; Tanaka, Nobuhiro ; Usui, Yasuhiro ; Takahashi, Nori ; Kurohane, Saiko ; Takei, Yasuyoshi ; Takata, Yoshifumi ; Yamashina, Akira</creator><creatorcontrib>Imai, Yasuko ; Tanaka, Nobuhiro ; Usui, Yasuhiro ; Takahashi, Nori ; Kurohane, Saiko ; Takei, Yasuyoshi ; Takata, Yoshifumi ; Yamashina, Akira</creatorcontrib><description>Purpose
Severe obstructive sleep apnea (OSA) directly impairs left ventricular (LV) diastolic function. Left atrial volume index (LAVI), an independent predictor of future cardiovascular events, is also related to OSA severity. This study aimed to assess whether OSA is associated with an increase in LAVI independently of LV diastolic function.
Methods
Two hundred six OSA patients (apnea hypopnea index, AHI ≥ 5/h) without cardiac disease, hypertension, and diabetes were enrolled. They underwent overnight fully attended polysomnography and 2-dimensional echocardiography in order to estimate LA volumes and LV diastolic function which was assessed by the ratio of transmitral early diastolic flow velocity to late diastolic flow velocity (E/A), deceleration time, and mitral annular velocity (e′) which was derived from tissue Doppler imaging. Patients were divided into two groups based on AHI, namely, group M (5 ≤ AHI < 30/h) and group S (AHI ≥ 30/h).
Results
The LAVI value in group S was significantly larger than that in group M (20 ± 5 vs. 23 ± 5 mL/m
2
,
P
< 0.001). E/A in group S was significantly lower than that in group M (
P
< 0.001), whereas the ratio of E to e′ (E/e′) in group S was significantly higher than that in group M (
P
< 0.001). AHI showed a statistically significant correlation with LAVI (
P
< 0.001). On multivariate linear regression analysis, severe OSA was independently related with LAVI even after adjusting for age, sex, systolic blood pressure, body mass index, and measurements of LV diastolic function (
P
= 0.04).
Conclusions
Severe OSA itself might directly increase LAVI, independently of LV diastolic function.</description><identifier>ISSN: 1520-9512</identifier><identifier>EISSN: 1522-1709</identifier><identifier>DOI: 10.1007/s11325-015-1153-7</identifier><identifier>PMID: 25778947</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Blood Flow Velocity - physiology ; Cardiac Volume - physiology ; Cardiovascular disease ; Dentistry ; Diastole - physiology ; Echocardiography, Doppler ; Electrocardiography ; Female ; Heart Atria - physiopathology ; Humans ; Internal Medicine ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Mitral Valve - physiopathology ; Neurology ; Original Article ; Otorhinolaryngology ; Pediatrics ; Pneumology/Respiratory System ; Polysomnography ; Sleep apnea ; Sleep Apnea, Obstructive - diagnosis ; Sleep Apnea, Obstructive - physiopathology ; Statistics as Topic ; Ventricular Dysfunction, Left - diagnosis ; Ventricular Dysfunction, Left - physiopathology</subject><ispartof>Sleep & breathing, 2015-12, Vol.19 (4), p.1249-1255</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c409t-3f3cd33853d71cb0f61256108499ee966fb09c674008459fb131be7b0c2b22643</citedby><cites>FETCH-LOGICAL-c409t-3f3cd33853d71cb0f61256108499ee966fb09c674008459fb131be7b0c2b22643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11325-015-1153-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11325-015-1153-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25778947$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Imai, Yasuko</creatorcontrib><creatorcontrib>Tanaka, Nobuhiro</creatorcontrib><creatorcontrib>Usui, Yasuhiro</creatorcontrib><creatorcontrib>Takahashi, Nori</creatorcontrib><creatorcontrib>Kurohane, Saiko</creatorcontrib><creatorcontrib>Takei, Yasuyoshi</creatorcontrib><creatorcontrib>Takata, Yoshifumi</creatorcontrib><creatorcontrib>Yamashina, Akira</creatorcontrib><title>Severe obstructive sleep apnea increases left atrial volume independently of left ventricular diastolic impairment</title><title>Sleep & breathing</title><addtitle>Sleep Breath</addtitle><addtitle>Sleep Breath</addtitle><description>Purpose
Severe obstructive sleep apnea (OSA) directly impairs left ventricular (LV) diastolic function. Left atrial volume index (LAVI), an independent predictor of future cardiovascular events, is also related to OSA severity. This study aimed to assess whether OSA is associated with an increase in LAVI independently of LV diastolic function.
Methods
Two hundred six OSA patients (apnea hypopnea index, AHI ≥ 5/h) without cardiac disease, hypertension, and diabetes were enrolled. They underwent overnight fully attended polysomnography and 2-dimensional echocardiography in order to estimate LA volumes and LV diastolic function which was assessed by the ratio of transmitral early diastolic flow velocity to late diastolic flow velocity (E/A), deceleration time, and mitral annular velocity (e′) which was derived from tissue Doppler imaging. Patients were divided into two groups based on AHI, namely, group M (5 ≤ AHI < 30/h) and group S (AHI ≥ 30/h).
Results
The LAVI value in group S was significantly larger than that in group M (20 ± 5 vs. 23 ± 5 mL/m
2
,
P
< 0.001). E/A in group S was significantly lower than that in group M (
P
< 0.001), whereas the ratio of E to e′ (E/e′) in group S was significantly higher than that in group M (
P
< 0.001). AHI showed a statistically significant correlation with LAVI (
P
< 0.001). On multivariate linear regression analysis, severe OSA was independently related with LAVI even after adjusting for age, sex, systolic blood pressure, body mass index, and measurements of LV diastolic function (
P
= 0.04).
Conclusions
Severe OSA itself might directly increase LAVI, independently of LV diastolic function.</description><subject>Adult</subject><subject>Blood Flow Velocity - physiology</subject><subject>Cardiac Volume - physiology</subject><subject>Cardiovascular disease</subject><subject>Dentistry</subject><subject>Diastole - physiology</subject><subject>Echocardiography, Doppler</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Heart Atria - physiopathology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mitral Valve - physiopathology</subject><subject>Neurology</subject><subject>Original Article</subject><subject>Otorhinolaryngology</subject><subject>Pediatrics</subject><subject>Pneumology/Respiratory System</subject><subject>Polysomnography</subject><subject>Sleep apnea</subject><subject>Sleep Apnea, Obstructive - diagnosis</subject><subject>Sleep Apnea, Obstructive - physiopathology</subject><subject>Statistics as Topic</subject><subject>Ventricular Dysfunction, Left - diagnosis</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>1520-9512</issn><issn>1522-1709</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1kE1LxDAQhoMo7rr6A7xIwHM1kzTN5ijiFyx4UM8hTacS6ZdJu-C_N9pVvHiZzOR95x14CDkFdgGMqcsIILjMGMgMQIpM7ZElSM4zUEzvf_cs0xL4ghzF-MYY5GsNh2TBpVJrnaslCU-4xYC0L-MYJjf6LdLYIA7UDh1a6jsX0EaMtMF6pHYM3jZ02zdTi0mscMBUurH5oH09e7ZpDN5NjQ208jaOfeMd9e1gfWiTdkwOattEPNm9K_Jye_N8fZ9tHu8erq82mcuZHjNRC1cJsZaiUuBKVhfAZQFsnWuNqIuiLpl2hcpZ-pK6LkFAiapkjpecF7lYkfM5dwj9-4RxNG_9FLp00oASCnKR8CUXzC4X-hgD1mYIvrXhwwAzX5TNTNkkyuaLslFp52yXPJUtVr8bP1iTgc-GmKTuFcOf0_-mfgKJN4jy</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Imai, Yasuko</creator><creator>Tanaka, Nobuhiro</creator><creator>Usui, Yasuhiro</creator><creator>Takahashi, Nori</creator><creator>Kurohane, Saiko</creator><creator>Takei, Yasuyoshi</creator><creator>Takata, Yoshifumi</creator><creator>Yamashina, Akira</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7T5</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>M2R</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope></search><sort><creationdate>20151201</creationdate><title>Severe obstructive sleep apnea increases left atrial volume independently of left ventricular diastolic impairment</title><author>Imai, Yasuko ; Tanaka, Nobuhiro ; Usui, Yasuhiro ; Takahashi, Nori ; Kurohane, Saiko ; Takei, Yasuyoshi ; Takata, Yoshifumi ; Yamashina, Akira</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c409t-3f3cd33853d71cb0f61256108499ee966fb09c674008459fb131be7b0c2b22643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adult</topic><topic>Blood Flow Velocity - physiology</topic><topic>Cardiac Volume - physiology</topic><topic>Cardiovascular disease</topic><topic>Dentistry</topic><topic>Diastole - physiology</topic><topic>Echocardiography, Doppler</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Heart Atria - physiopathology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mitral Valve - physiopathology</topic><topic>Neurology</topic><topic>Original Article</topic><topic>Otorhinolaryngology</topic><topic>Pediatrics</topic><topic>Pneumology/Respiratory System</topic><topic>Polysomnography</topic><topic>Sleep apnea</topic><topic>Sleep Apnea, Obstructive - diagnosis</topic><topic>Sleep Apnea, Obstructive - physiopathology</topic><topic>Statistics as Topic</topic><topic>Ventricular Dysfunction, Left - diagnosis</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Imai, Yasuko</creatorcontrib><creatorcontrib>Tanaka, Nobuhiro</creatorcontrib><creatorcontrib>Usui, Yasuhiro</creatorcontrib><creatorcontrib>Takahashi, Nori</creatorcontrib><creatorcontrib>Kurohane, Saiko</creatorcontrib><creatorcontrib>Takei, Yasuyoshi</creatorcontrib><creatorcontrib>Takata, Yoshifumi</creatorcontrib><creatorcontrib>Yamashina, Akira</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>Social Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><jtitle>Sleep & breathing</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Imai, Yasuko</au><au>Tanaka, Nobuhiro</au><au>Usui, Yasuhiro</au><au>Takahashi, Nori</au><au>Kurohane, Saiko</au><au>Takei, Yasuyoshi</au><au>Takata, Yoshifumi</au><au>Yamashina, Akira</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Severe obstructive sleep apnea increases left atrial volume independently of left ventricular diastolic impairment</atitle><jtitle>Sleep & breathing</jtitle><stitle>Sleep Breath</stitle><addtitle>Sleep Breath</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>19</volume><issue>4</issue><spage>1249</spage><epage>1255</epage><pages>1249-1255</pages><issn>1520-9512</issn><eissn>1522-1709</eissn><abstract>Purpose
Severe obstructive sleep apnea (OSA) directly impairs left ventricular (LV) diastolic function. Left atrial volume index (LAVI), an independent predictor of future cardiovascular events, is also related to OSA severity. This study aimed to assess whether OSA is associated with an increase in LAVI independently of LV diastolic function.
Methods
Two hundred six OSA patients (apnea hypopnea index, AHI ≥ 5/h) without cardiac disease, hypertension, and diabetes were enrolled. They underwent overnight fully attended polysomnography and 2-dimensional echocardiography in order to estimate LA volumes and LV diastolic function which was assessed by the ratio of transmitral early diastolic flow velocity to late diastolic flow velocity (E/A), deceleration time, and mitral annular velocity (e′) which was derived from tissue Doppler imaging. Patients were divided into two groups based on AHI, namely, group M (5 ≤ AHI < 30/h) and group S (AHI ≥ 30/h).
Results
The LAVI value in group S was significantly larger than that in group M (20 ± 5 vs. 23 ± 5 mL/m
2
,
P
< 0.001). E/A in group S was significantly lower than that in group M (
P
< 0.001), whereas the ratio of E to e′ (E/e′) in group S was significantly higher than that in group M (
P
< 0.001). AHI showed a statistically significant correlation with LAVI (
P
< 0.001). On multivariate linear regression analysis, severe OSA was independently related with LAVI even after adjusting for age, sex, systolic blood pressure, body mass index, and measurements of LV diastolic function (
P
= 0.04).
Conclusions
Severe OSA itself might directly increase LAVI, independently of LV diastolic function.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25778947</pmid><doi>10.1007/s11325-015-1153-7</doi><tpages>7</tpages></addata></record> |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Blood Flow Velocity - physiology Cardiac Volume - physiology Cardiovascular disease Dentistry Diastole - physiology Echocardiography, Doppler Electrocardiography Female Heart Atria - physiopathology Humans Internal Medicine Male Medicine Medicine & Public Health Middle Aged Mitral Valve - physiopathology Neurology Original Article Otorhinolaryngology Pediatrics Pneumology/Respiratory System Polysomnography Sleep apnea Sleep Apnea, Obstructive - diagnosis Sleep Apnea, Obstructive - physiopathology Statistics as Topic Ventricular Dysfunction, Left - diagnosis Ventricular Dysfunction, Left - physiopathology |
| title | Severe obstructive sleep apnea increases left atrial volume independently of left ventricular diastolic impairment |
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