Single-molecule view of basal activity and activation mechanisms of the G protein-coupled receptor [Beta]^sub 2^AR

Binding of extracellular ligands to G protein-coupled receptors (GPCRs) initiates transmembrane signaling by inducing conformational changes on the cytoplasmic receptor surface. Knowledge of this process provides a platform for the development of GPCR-targeting drugs. Here, using a site-specific Cy3...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-11, Vol.112 (46), p.14254
Hauptverfasser:	Lamichhane, Rajan, Liu, Jeffrey J, Pljevaljcic, Goran, White, Kate L, van der Schans, Edwin, Katritch, Vsevolod, Stevens, Raymond C, Wüthrich, Kurt, Millar, David P
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Fluorescence Molecules Pharmacology Proteins
Online-Zugang:	Volltext
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