Infections caused by Fusobacterium in children: a 14-year single-center experience
Purpose This study aimed at reviewing our experience with infections caused by Fusobacterium in children. Methods A retrospective analysis of medical records of children admitted to Hadassah-Hebrew University Medical Center from 2000 to 2013, in whom Fusobacterium spp. was identified in any specimen...
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| Veröffentlicht in: | Infection 2015-12, Vol.43 (6), p.663-670 |
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| creator | Shamriz, Oded Engelhard, Dan Temper, Violeta Revel-Vilk, Shoshana Benenson, Shmuel Brooks, Rebecca Tenenbaum, Ariel Stepensky, Polina Koplewitz, Benjamin Kaufmann, Michal Averbuch, Diana |
| description | Purpose
This study aimed at reviewing our experience with infections caused by
Fusobacterium
in children.
Methods
A retrospective analysis of medical records of children admitted to Hadassah-Hebrew University Medical Center from 2000 to 2013, in whom
Fusobacterium
spp. was identified in any specimen.
Results
A total of 22 patients (males = 12) at a mean ± SE age of 5 ± 1 (range 1–17) years, were identified. The most common complication was abscess formation (
n
= 11, 50 %). Eight children (36.4 %) had intracranial complications, including brain abscess (
n
= 4), meningitis (
n
= 4) and cerebral sinus vein thrombosis (CSVT,
n
= 5). Seventeen children (77 %) had bacteremia. Primary site of infection was otogenic (
n
= 9), oropharyngeal (
n
= 7), respiratory (
n
= 2), sinuses (
n
= 2), intra-abdominal (
n
= 1) and mucositis (
n
= 1). Fourteen cases were caused by
Fusobacterium necrophorum
, including four cases with CSVT, 7/8 cases of mastoiditis, four of them with subperiosteal abscess formation; all four cases with meningitis and two brain abscesses. Fifteen (68 %) patients required surgical intervention and 3 (14 %) received anti-coagulation therapy. Excluding one patient with overwhelming sepsis with fatal outcome, all patients recovered.
Conclusions
Fusobacterium
infections in children can cause a diverse spectrum of disease and is associated with high rates of abscess formation and intracranial complications. Although
Fusobacterium nucleatum
is abundant in the oral cavity,
F. necrophorum
is the main pathogen that causes severe infections in healthy children. |
| doi_str_mv | 10.1007/s15010-015-0782-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1735606958</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3874613451</sourcerecordid><originalsourceid>FETCH-LOGICAL-c475t-a2e8a1ab8177fe434eb24daafbd27a5d0375a45f786dafe227c48ee091d33f863</originalsourceid><addsrcrecordid>eNp1kE1LAzEURYMotlZ_gBsJuI6-fE1m3EmxWigIouuQybypU9pMTTrQ_nuntIobV2_xzr0XDiHXHO44gLlPXAMHBlwzMLlg2xMy5EoWDAojT8kQJADLucgG5CKlBQDoQplzMhC6EIXixZC8TUONftO0IVHvuoQVLXd00qW2dH6DselWtAnUfzbLKmJ4oI5yxXboIk1NmC-ReQw9R3G77mkMHi_JWe2WCa-Od0Q-Jk_v4xc2e32ejh9nzCujN8wJzB13Zc6NqVFJhaVQlXN1WQnjdAXSaKd0bfKscjUKYbzKEaHglZR1nskRuT30rmP71WHa2EXbxdBPWm6kziArdN5T_ED52KYUsbbr2Kxc3FkOdm_RHiza3qLdW7TbPnNzbO7KFVa_iR9tPSAOQOpfYY7xz_S_rd-iuH2W</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1735606958</pqid></control><display><type>article</type><title>Infections caused by Fusobacterium in children: a 14-year single-center experience</title><source>MEDLINE</source><source>Springer LINK 全文期刊数据库</source><creator>Shamriz, Oded ; Engelhard, Dan ; Temper, Violeta ; Revel-Vilk, Shoshana ; Benenson, Shmuel ; Brooks, Rebecca ; Tenenbaum, Ariel ; Stepensky, Polina ; Koplewitz, Benjamin ; Kaufmann, Michal ; Averbuch, Diana</creator><creatorcontrib>Shamriz, Oded ; Engelhard, Dan ; Temper, Violeta ; Revel-Vilk, Shoshana ; Benenson, Shmuel ; Brooks, Rebecca ; Tenenbaum, Ariel ; Stepensky, Polina ; Koplewitz, Benjamin ; Kaufmann, Michal ; Averbuch, Diana</creatorcontrib><description>Purpose
This study aimed at reviewing our experience with infections caused by
Fusobacterium
in children.
Methods
A retrospective analysis of medical records of children admitted to Hadassah-Hebrew University Medical Center from 2000 to 2013, in whom
Fusobacterium
spp. was identified in any specimen.
Results
A total of 22 patients (males = 12) at a mean ± SE age of 5 ± 1 (range 1–17) years, were identified. The most common complication was abscess formation (
n
= 11, 50 %). Eight children (36.4 %) had intracranial complications, including brain abscess (
n
= 4), meningitis (
n
= 4) and cerebral sinus vein thrombosis (CSVT,
n
= 5). Seventeen children (77 %) had bacteremia. Primary site of infection was otogenic (
n
= 9), oropharyngeal (
n
= 7), respiratory (
n
= 2), sinuses (
n
= 2), intra-abdominal (
n
= 1) and mucositis (
n
= 1). Fourteen cases were caused by
Fusobacterium necrophorum
, including four cases with CSVT, 7/8 cases of mastoiditis, four of them with subperiosteal abscess formation; all four cases with meningitis and two brain abscesses. Fifteen (68 %) patients required surgical intervention and 3 (14 %) received anti-coagulation therapy. Excluding one patient with overwhelming sepsis with fatal outcome, all patients recovered.
Conclusions
Fusobacterium
infections in children can cause a diverse spectrum of disease and is associated with high rates of abscess formation and intracranial complications. Although
Fusobacterium nucleatum
is abundant in the oral cavity,
F. necrophorum
is the main pathogen that causes severe infections in healthy children.</description><identifier>ISSN: 0300-8126</identifier><identifier>EISSN: 1439-0973</identifier><identifier>DOI: 10.1007/s15010-015-0782-x</identifier><identifier>PMID: 25929419</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Abscess - epidemiology ; Abscess - microbiology ; Abscess - pathology ; Adolescent ; Child ; Child, Preschool ; Family Medicine ; Female ; Fusobacterium Infections - epidemiology ; Fusobacterium Infections - microbiology ; Fusobacterium Infections - pathology ; Fusobacterium necrophorum - isolation & purification ; General Practice ; Humans ; Infant ; Infectious Diseases ; Internal Medicine ; Israel - epidemiology ; Male ; Medicine ; Medicine & Public Health ; Original Paper ; Retrospective Studies ; Thromboembolism</subject><ispartof>Infection, 2015-12, Vol.43 (6), p.663-670</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c475t-a2e8a1ab8177fe434eb24daafbd27a5d0375a45f786dafe227c48ee091d33f863</citedby><cites>FETCH-LOGICAL-c475t-a2e8a1ab8177fe434eb24daafbd27a5d0375a45f786dafe227c48ee091d33f863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s15010-015-0782-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s15010-015-0782-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27933,27934,41497,42566,51328</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/25929419$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shamriz, Oded</creatorcontrib><creatorcontrib>Engelhard, Dan</creatorcontrib><creatorcontrib>Temper, Violeta</creatorcontrib><creatorcontrib>Revel-Vilk, Shoshana</creatorcontrib><creatorcontrib>Benenson, Shmuel</creatorcontrib><creatorcontrib>Brooks, Rebecca</creatorcontrib><creatorcontrib>Tenenbaum, Ariel</creatorcontrib><creatorcontrib>Stepensky, Polina</creatorcontrib><creatorcontrib>Koplewitz, Benjamin</creatorcontrib><creatorcontrib>Kaufmann, Michal</creatorcontrib><creatorcontrib>Averbuch, Diana</creatorcontrib><title>Infections caused by Fusobacterium in children: a 14-year single-center experience</title><title>Infection</title><addtitle>Infection</addtitle><addtitle>Infection</addtitle><description>Purpose
This study aimed at reviewing our experience with infections caused by
Fusobacterium
in children.
Methods
A retrospective analysis of medical records of children admitted to Hadassah-Hebrew University Medical Center from 2000 to 2013, in whom
Fusobacterium
spp. was identified in any specimen.
Results
A total of 22 patients (males = 12) at a mean ± SE age of 5 ± 1 (range 1–17) years, were identified. The most common complication was abscess formation (
n
= 11, 50 %). Eight children (36.4 %) had intracranial complications, including brain abscess (
n
= 4), meningitis (
n
= 4) and cerebral sinus vein thrombosis (CSVT,
n
= 5). Seventeen children (77 %) had bacteremia. Primary site of infection was otogenic (
n
= 9), oropharyngeal (
n
= 7), respiratory (
n
= 2), sinuses (
n
= 2), intra-abdominal (
n
= 1) and mucositis (
n
= 1). Fourteen cases were caused by
Fusobacterium necrophorum
, including four cases with CSVT, 7/8 cases of mastoiditis, four of them with subperiosteal abscess formation; all four cases with meningitis and two brain abscesses. Fifteen (68 %) patients required surgical intervention and 3 (14 %) received anti-coagulation therapy. Excluding one patient with overwhelming sepsis with fatal outcome, all patients recovered.
Conclusions
Fusobacterium
infections in children can cause a diverse spectrum of disease and is associated with high rates of abscess formation and intracranial complications. Although
Fusobacterium nucleatum
is abundant in the oral cavity,
F. necrophorum
is the main pathogen that causes severe infections in healthy children.</description><subject>Abscess - epidemiology</subject><subject>Abscess - microbiology</subject><subject>Abscess - pathology</subject><subject>Adolescent</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Family Medicine</subject><subject>Female</subject><subject>Fusobacterium Infections - epidemiology</subject><subject>Fusobacterium Infections - microbiology</subject><subject>Fusobacterium Infections - pathology</subject><subject>Fusobacterium necrophorum - isolation & purification</subject><subject>General Practice</subject><subject>Humans</subject><subject>Infant</subject><subject>Infectious Diseases</subject><subject>Internal Medicine</subject><subject>Israel - epidemiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Paper</subject><subject>Retrospective Studies</subject><subject>Thromboembolism</subject><issn>0300-8126</issn><issn>1439-0973</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp1kE1LAzEURYMotlZ_gBsJuI6-fE1m3EmxWigIouuQybypU9pMTTrQ_nuntIobV2_xzr0XDiHXHO44gLlPXAMHBlwzMLlg2xMy5EoWDAojT8kQJADLucgG5CKlBQDoQplzMhC6EIXixZC8TUONftO0IVHvuoQVLXd00qW2dH6DselWtAnUfzbLKmJ4oI5yxXboIk1NmC-ReQw9R3G77mkMHi_JWe2WCa-Od0Q-Jk_v4xc2e32ejh9nzCujN8wJzB13Zc6NqVFJhaVQlXN1WQnjdAXSaKd0bfKscjUKYbzKEaHglZR1nskRuT30rmP71WHa2EXbxdBPWm6kziArdN5T_ED52KYUsbbr2Kxc3FkOdm_RHiza3qLdW7TbPnNzbO7KFVa_iR9tPSAOQOpfYY7xz_S_rd-iuH2W</recordid><startdate>20151201</startdate><enddate>20151201</enddate><creator>Shamriz, Oded</creator><creator>Engelhard, Dan</creator><creator>Temper, Violeta</creator><creator>Revel-Vilk, Shoshana</creator><creator>Benenson, Shmuel</creator><creator>Brooks, Rebecca</creator><creator>Tenenbaum, Ariel</creator><creator>Stepensky, Polina</creator><creator>Koplewitz, Benjamin</creator><creator>Kaufmann, Michal</creator><creator>Averbuch, Diana</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>RC3</scope></search><sort><creationdate>20151201</creationdate><title>Infections caused by Fusobacterium in children: a 14-year single-center experience</title><author>Shamriz, Oded ; Engelhard, Dan ; Temper, Violeta ; Revel-Vilk, Shoshana ; Benenson, Shmuel ; Brooks, Rebecca ; Tenenbaum, Ariel ; Stepensky, Polina ; Koplewitz, Benjamin ; Kaufmann, Michal ; Averbuch, Diana</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c475t-a2e8a1ab8177fe434eb24daafbd27a5d0375a45f786dafe227c48ee091d33f863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Abscess - epidemiology</topic><topic>Abscess - microbiology</topic><topic>Abscess - pathology</topic><topic>Adolescent</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Family Medicine</topic><topic>Female</topic><topic>Fusobacterium Infections - epidemiology</topic><topic>Fusobacterium Infections - microbiology</topic><topic>Fusobacterium Infections - pathology</topic><topic>Fusobacterium necrophorum - isolation & purification</topic><topic>General Practice</topic><topic>Humans</topic><topic>Infant</topic><topic>Infectious Diseases</topic><topic>Internal Medicine</topic><topic>Israel - epidemiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Paper</topic><topic>Retrospective Studies</topic><topic>Thromboembolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Shamriz, Oded</creatorcontrib><creatorcontrib>Engelhard, Dan</creatorcontrib><creatorcontrib>Temper, Violeta</creatorcontrib><creatorcontrib>Revel-Vilk, Shoshana</creatorcontrib><creatorcontrib>Benenson, Shmuel</creatorcontrib><creatorcontrib>Brooks, Rebecca</creatorcontrib><creatorcontrib>Tenenbaum, Ariel</creatorcontrib><creatorcontrib>Stepensky, Polina</creatorcontrib><creatorcontrib>Koplewitz, Benjamin</creatorcontrib><creatorcontrib>Kaufmann, Michal</creatorcontrib><creatorcontrib>Averbuch, Diana</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Nursing & Allied Health Database (ProQuest)</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>Genetics Abstracts</collection><jtitle>Infection</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shamriz, Oded</au><au>Engelhard, Dan</au><au>Temper, Violeta</au><au>Revel-Vilk, Shoshana</au><au>Benenson, Shmuel</au><au>Brooks, Rebecca</au><au>Tenenbaum, Ariel</au><au>Stepensky, Polina</au><au>Koplewitz, Benjamin</au><au>Kaufmann, Michal</au><au>Averbuch, Diana</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Infections caused by Fusobacterium in children: a 14-year single-center experience</atitle><jtitle>Infection</jtitle><stitle>Infection</stitle><addtitle>Infection</addtitle><date>2015-12-01</date><risdate>2015</risdate><volume>43</volume><issue>6</issue><spage>663</spage><epage>670</epage><pages>663-670</pages><issn>0300-8126</issn><eissn>1439-0973</eissn><abstract>Purpose
This study aimed at reviewing our experience with infections caused by
Fusobacterium
in children.
Methods
A retrospective analysis of medical records of children admitted to Hadassah-Hebrew University Medical Center from 2000 to 2013, in whom
Fusobacterium
spp. was identified in any specimen.
Results
A total of 22 patients (males = 12) at a mean ± SE age of 5 ± 1 (range 1–17) years, were identified. The most common complication was abscess formation (
n
= 11, 50 %). Eight children (36.4 %) had intracranial complications, including brain abscess (
n
= 4), meningitis (
n
= 4) and cerebral sinus vein thrombosis (CSVT,
n
= 5). Seventeen children (77 %) had bacteremia. Primary site of infection was otogenic (
n
= 9), oropharyngeal (
n
= 7), respiratory (
n
= 2), sinuses (
n
= 2), intra-abdominal (
n
= 1) and mucositis (
n
= 1). Fourteen cases were caused by
Fusobacterium necrophorum
, including four cases with CSVT, 7/8 cases of mastoiditis, four of them with subperiosteal abscess formation; all four cases with meningitis and two brain abscesses. Fifteen (68 %) patients required surgical intervention and 3 (14 %) received anti-coagulation therapy. Excluding one patient with overwhelming sepsis with fatal outcome, all patients recovered.
Conclusions
Fusobacterium
infections in children can cause a diverse spectrum of disease and is associated with high rates of abscess formation and intracranial complications. Although
Fusobacterium nucleatum
is abundant in the oral cavity,
F. necrophorum
is the main pathogen that causes severe infections in healthy children.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>25929419</pmid><doi>10.1007/s15010-015-0782-x</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0300-8126 |
| ispartof | Infection, 2015-12, Vol.43 (6), p.663-670 |
| issn | 0300-8126 1439-0973 |
| language | eng |
| recordid | cdi_proquest_journals_1735606958 |
| source | MEDLINE; Springer LINK 全文期刊数据库 |
| subjects | Abscess - epidemiology Abscess - microbiology Abscess - pathology Adolescent Child Child, Preschool Family Medicine Female Fusobacterium Infections - epidemiology Fusobacterium Infections - microbiology Fusobacterium Infections - pathology Fusobacterium necrophorum - isolation & purification General Practice Humans Infant Infectious Diseases Internal Medicine Israel - epidemiology Male Medicine Medicine & Public Health Original Paper Retrospective Studies Thromboembolism |
| title | Infections caused by Fusobacterium in children: a 14-year single-center experience |
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