Synthesis, Structural Characterization and Preliminary Biological Studies of Several Heterocyclic Transition Metal Carbonyl Complexes
The reaction of molybdenum, tungsten and manganese carbonyls with several thiazole heterocycle ligands yielded a number of coordinated transition metal complexes 1–10. Of these complexes 1–6 are new compounds which have not been reported to date. The structures of new compounds were characterized by...
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| Veröffentlicht in: | Zeitschrift für anorganische und allgemeine Chemie (1950) 2015-11, Vol.641 (14), p.2452-2459 |
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| container_issue | 14 |
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| container_title | Zeitschrift für anorganische und allgemeine Chemie (1950) |
| container_volume | 641 |
| creator | Hu, Shanfang Cui, Xianwei He, Weimin Chen, Xiangyi Gu, Zikuan Zhao, Jingzhe Zeng, Guang Shi, Zhan Zhu, Lei Nie, Hemin |
| description | The reaction of molybdenum, tungsten and manganese carbonyls with several thiazole heterocycle ligands yielded a number of coordinated transition metal complexes 1–10. Of these complexes 1–6 are new compounds which have not been reported to date. The structures of new compounds were characterized by FT‐IR and 1H‐NMR spectroscopy as well as single‐crystal X‐ray diffraction analysis. Complexes 1–10 are carbon monoxide releasing molecules that show structure‐related anti‐cancer activity. The cytotoxicity of all compounds on Hela cells was evaluated by MTT assay, and the results show that carbon monoxide releasing molecules containing such Schiff base ligands may have biomedical applications for their anti‐tumor effect. |
| doi_str_mv | 10.1002/zaac.201500592 |
| format | Article |
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Of these complexes 1–6 are new compounds which have not been reported to date. The structures of new compounds were characterized by FT‐IR and 1H‐NMR spectroscopy as well as single‐crystal X‐ray diffraction analysis. Complexes 1–10 are carbon monoxide releasing molecules that show structure‐related anti‐cancer activity. The cytotoxicity of all compounds on Hela cells was evaluated by MTT assay, and the results show that carbon monoxide releasing molecules containing such Schiff base ligands may have biomedical applications for their anti‐tumor effect.</description><identifier>ISSN: 0044-2313</identifier><identifier>EISSN: 1521-3749</identifier><identifier>DOI: 10.1002/zaac.201500592</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Carbon monoxide ; Crystals ; Cytotoxicity ; Ligands ; Manganese ; Molybdenum ; Transition metal carbonyl complexes ; Tungsten</subject><ispartof>Zeitschrift für anorganische und allgemeine Chemie (1950), 2015-11, Vol.641 (14), p.2452-2459</ispartof><rights>Copyright © 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>Copyright © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3552-dc2d5d760049100940feb276be18a78cce6f05276a49e00198306e2fc1a05ee83</citedby><cites>FETCH-LOGICAL-c3552-dc2d5d760049100940feb276be18a78cce6f05276a49e00198306e2fc1a05ee83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fzaac.201500592$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fzaac.201500592$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids></links><search><creatorcontrib>Hu, Shanfang</creatorcontrib><creatorcontrib>Cui, Xianwei</creatorcontrib><creatorcontrib>He, Weimin</creatorcontrib><creatorcontrib>Chen, Xiangyi</creatorcontrib><creatorcontrib>Gu, Zikuan</creatorcontrib><creatorcontrib>Zhao, Jingzhe</creatorcontrib><creatorcontrib>Zeng, Guang</creatorcontrib><creatorcontrib>Shi, Zhan</creatorcontrib><creatorcontrib>Zhu, Lei</creatorcontrib><creatorcontrib>Nie, Hemin</creatorcontrib><title>Synthesis, Structural Characterization and Preliminary Biological Studies of Several Heterocyclic Transition Metal Carbonyl Complexes</title><title>Zeitschrift für anorganische und allgemeine Chemie (1950)</title><addtitle>Z. anorg. allg. Chem</addtitle><description>The reaction of molybdenum, tungsten and manganese carbonyls with several thiazole heterocycle ligands yielded a number of coordinated transition metal complexes 1–10. Of these complexes 1–6 are new compounds which have not been reported to date. The structures of new compounds were characterized by FT‐IR and 1H‐NMR spectroscopy as well as single‐crystal X‐ray diffraction analysis. Complexes 1–10 are carbon monoxide releasing molecules that show structure‐related anti‐cancer activity. The cytotoxicity of all compounds on Hela cells was evaluated by MTT assay, and the results show that carbon monoxide releasing molecules containing such Schiff base ligands may have biomedical applications for their anti‐tumor effect.</description><subject>Carbon monoxide</subject><subject>Crystals</subject><subject>Cytotoxicity</subject><subject>Ligands</subject><subject>Manganese</subject><subject>Molybdenum</subject><subject>Transition metal carbonyl complexes</subject><subject>Tungsten</subject><issn>0044-2313</issn><issn>1521-3749</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNqFkM1P4zAQxS3ESltYrnuOxJWUsRMnzbFEfIqySAUhcbFcZwKGNC62s0t65__GoQjtjZNH1vu9mfcI-U1hTAHY4VpKNWZAOQAv2BYZUc5onORpsU1GAGkas4QmP8mOc08AQIHzEXmb961_RKfdQTT3tlO-s7KJykdppfJo9Vp6bdpItlV0bbHRS91K20dH2jTmQaugnfuu0ugiU0dz_IsDfoYBNapXjVbRjZWt0x8uM_SDubQL0_ZhMMtVg6_ofpEftWwc7n2-u-T25PimPIsv_5yel9PLWCWcs7hSrOJVnoUwRYhcpFDjguXZAulE5hOlMKuBhw-ZFhgSFpMEMmS1ohI44iTZJfsb35U1Lx06L55MZ9uwUtCcFXmSc2BBNd6olDXOWazFyuplSC0oiKFqMVQtvqoOQLEB_ukG-2_U4n46Lf9n4w2rncfXL1baZ5EN94i7q1NxcTdj13BVCpa8A9SMlBE</recordid><startdate>201511</startdate><enddate>201511</enddate><creator>Hu, Shanfang</creator><creator>Cui, Xianwei</creator><creator>He, Weimin</creator><creator>Chen, Xiangyi</creator><creator>Gu, Zikuan</creator><creator>Zhao, Jingzhe</creator><creator>Zeng, Guang</creator><creator>Shi, Zhan</creator><creator>Zhu, Lei</creator><creator>Nie, Hemin</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>AAYXX</scope><scope>CITATION</scope></search><sort><creationdate>201511</creationdate><title>Synthesis, Structural Characterization and Preliminary Biological Studies of Several Heterocyclic Transition Metal Carbonyl Complexes</title><author>Hu, Shanfang ; Cui, Xianwei ; He, Weimin ; Chen, Xiangyi ; Gu, Zikuan ; Zhao, Jingzhe ; Zeng, Guang ; Shi, Zhan ; Zhu, Lei ; Nie, Hemin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3552-dc2d5d760049100940feb276be18a78cce6f05276a49e00198306e2fc1a05ee83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Carbon monoxide</topic><topic>Crystals</topic><topic>Cytotoxicity</topic><topic>Ligands</topic><topic>Manganese</topic><topic>Molybdenum</topic><topic>Transition metal carbonyl complexes</topic><topic>Tungsten</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hu, Shanfang</creatorcontrib><creatorcontrib>Cui, Xianwei</creatorcontrib><creatorcontrib>He, Weimin</creatorcontrib><creatorcontrib>Chen, Xiangyi</creatorcontrib><creatorcontrib>Gu, Zikuan</creatorcontrib><creatorcontrib>Zhao, Jingzhe</creatorcontrib><creatorcontrib>Zeng, Guang</creatorcontrib><creatorcontrib>Shi, Zhan</creatorcontrib><creatorcontrib>Zhu, Lei</creatorcontrib><creatorcontrib>Nie, Hemin</creatorcontrib><collection>Istex</collection><collection>CrossRef</collection><jtitle>Zeitschrift für anorganische und allgemeine Chemie (1950)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hu, Shanfang</au><au>Cui, Xianwei</au><au>He, Weimin</au><au>Chen, Xiangyi</au><au>Gu, Zikuan</au><au>Zhao, Jingzhe</au><au>Zeng, Guang</au><au>Shi, Zhan</au><au>Zhu, Lei</au><au>Nie, Hemin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis, Structural Characterization and Preliminary Biological Studies of Several Heterocyclic Transition Metal Carbonyl Complexes</atitle><jtitle>Zeitschrift für anorganische und allgemeine Chemie (1950)</jtitle><addtitle>Z. anorg. allg. Chem</addtitle><date>2015-11</date><risdate>2015</risdate><volume>641</volume><issue>14</issue><spage>2452</spage><epage>2459</epage><pages>2452-2459</pages><issn>0044-2313</issn><eissn>1521-3749</eissn><abstract>The reaction of molybdenum, tungsten and manganese carbonyls with several thiazole heterocycle ligands yielded a number of coordinated transition metal complexes 1–10. Of these complexes 1–6 are new compounds which have not been reported to date. The structures of new compounds were characterized by FT‐IR and 1H‐NMR spectroscopy as well as single‐crystal X‐ray diffraction analysis. Complexes 1–10 are carbon monoxide releasing molecules that show structure‐related anti‐cancer activity. The cytotoxicity of all compounds on Hela cells was evaluated by MTT assay, and the results show that carbon monoxide releasing molecules containing such Schiff base ligands may have biomedical applications for their anti‐tumor effect.</abstract><cop>Weinheim</cop><pub>WILEY-VCH Verlag</pub><doi>10.1002/zaac.201500592</doi><tpages>8</tpages></addata></record> |
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| issn | 0044-2313 1521-3749 |
| language | eng |
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| source | Wiley Journals |
| subjects | Carbon monoxide Crystals Cytotoxicity Ligands Manganese Molybdenum Transition metal carbonyl complexes Tungsten |
| title | Synthesis, Structural Characterization and Preliminary Biological Studies of Several Heterocyclic Transition Metal Carbonyl Complexes |
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