Heterozygous inactivation of plasma membrane Ca^sup 2+^-ATPase in mice increases glucose-induced insulin release and beta cell proliferation, mass and viability

Aims/hypothesis Calcium plays an important role in the process of glucose-induced insulin release in pancreatic beta cells. These cells are equipped with a double system responsible for Ca^sup 2+^ extrusion--the Na/Ca exchanger (NCX) and the plasma membrane Ca^sup 2+^-ATPase (PMCA). We have shown th...

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Veröffentlicht in:	Diabetologia 2015-12, Vol.58 (12), p.2843
Hauptverfasser:	Pachera, Nathalie, Papin, Julien, Zummo, Francesco P, Rahier, Jacques, Mast, Jan, Meyerovich, Kira, Cardozo, Alessandra K, Herchuelz, André
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell growth Diabetes Glucose Insulin Laboratory animals Metabolism Plasma Proteins
Online-Zugang:	Volltext
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