Cationic Cobalt(III)-Catalyzed Aryl and Alkenyl CH Amidation: A Mild Protocol for the Modification of Purine Derivatives

A cationic cobalt(III)-catalyzed direct CH amidation of unactivated (hetero)arenes and alkenes by using 1,4,2-dioxazol-5-ones as the amidating reagent has been developed. This transformation proceeds efficiently under external oxidant-free conditions with a broad substrate scope. Moreover, 6-arylpur...

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Veröffentlicht in:	Chemistry : a European journal 2015-11, Vol.21 (46), p.16395
Hauptverfasser:	Liang, Yujie, Liang, Yu-Feng, Tang, Conghui, Yuan, Yizhi, Jiao, Ning
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry
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creator	Liang, Yujie Liang, Yu-Feng Tang, Conghui Yuan, Yizhi Jiao, Ning
description	A cationic cobalt(III)-catalyzed direct CH amidation of unactivated (hetero)arenes and alkenes by using 1,4,2-dioxazol-5-ones as the amidating reagent has been developed. This transformation proceeds efficiently under external oxidant-free conditions with a broad substrate scope. Moreover, 6-arylpurine compounds, which often exhibit high potency in antimycobacterial, cytostatic, and anti-HCV activities, can be smoothly amidated, thus offering a mild protocol for their late stage functionalization.
doi_str_mv	10.1002/chem.201503533
format	Article
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title	Cationic Cobalt(III)-Catalyzed Aryl and Alkenyl CH Amidation: A Mild Protocol for the Modification of Purine Derivatives
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