A Novel Stability Indicating HPLC Assay Method for Simultaneous Estimation of Clopidogrel and Aspirin in Tablet dosage form by Using Core shell Technology column
A novel, rapid and a stability-indicating reverse phase LC method has been developed and validated for the simultaneous estimation of Clopidogrel and Aspirin in tablet dosage form. The chromatographic separation was achieved on a novel core shell technology phenyl hexyl stationary phase of particle...
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| Veröffentlicht in: | Research journal of pharmacy and technology 2015-02, Vol.8 (2), p.172-176 |
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| container_end_page | 176 |
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| container_title | Research journal of pharmacy and technology |
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| creator | Mahesh, HRK Babu, K Sudhakar |
| description | A novel, rapid and a stability-indicating reverse phase LC method has been developed and validated for the simultaneous estimation of Clopidogrel and Aspirin in tablet dosage form. The chromatographic separation was achieved on a novel core shell technology phenyl hexyl stationary phase of particle size 2.6μ. The method employed a linear gradient elution and the detection wavelength was set at 220nm. The proposed method was extensively validated as per ICH guidelines. The specificity of the method was proved by performing forced degradation studies. Regression analysis shows r value (correlation coefficient) of greater than 0.999 for individual active drug substances. Accuracy was proved in the range of 50% to 150% of working range. |
| doi_str_mv | 10.5958/0974-360X.2015.00031.1 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0974-3618 |
| ispartof | Research journal of pharmacy and technology, 2015-02, Vol.8 (2), p.172-176 |
| issn | 0974-3618 0974-360X 0974-306X |
| language | eng |
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| source | Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Aspirin Clopidogrel Core shell Simultaneous estimation Stability indicating |
| title | A Novel Stability Indicating HPLC Assay Method for Simultaneous Estimation of Clopidogrel and Aspirin in Tablet dosage form by Using Core shell Technology column |
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